ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1177	423/7206	1.05714461251e-42
ko04724	Glutamatergic synapse	89/1177	152/7206	6.60154449132e-33
ko05033	Nicotine addiction	47/1177	56/7206	7.92449671738e-29
ko05032	Morphine addiction	67/1177	110/7206	2.10962869365e-26
ko04727	GABAergic synapse	64/1177	110/7206	1.05499920142e-23
ko04713	Circadian entrainment	72/1177	136/7206	3.82667169009e-23
ko04721	Synaptic vesicle cycle	51/1177	80/7206	1.17743225693e-21
ko04728	Dopaminergic synapse	84/1177	185/7206	4.51481418287e-21
ko04725	Cholinergic synapse	74/1177	160/7206	2.9507774233e-19
ko04723	Retrograde endocannabinoid signaling	78/1177	175/7206	4.86991874389e-19
ko04024	cAMP signaling pathway	102/1177	279/7206	5.47393149755e-17
ko04744	Phototransduction	27/1177	36/7206	9.16570052144e-15
ko04911	Insulin secretion	53/1177	117/7206	1.14521259966e-13
ko04020	Calcium signaling pathway	91/1177	265/7206	2.5615285143e-13
ko04742	Taste transduction	35/1177	61/7206	2.87586987624e-13
ko04921	Oxytocin signaling pathway	77/1177	209/7206	3.02576420895e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1177	205/7206	3.30533088764e-11
ko04726	Serotonergic synapse	54/1177	137/7206	7.45814309317e-11
ko03040	Spliceosome	1/1177	145/7206	1.95321084154e-10
ko05031	Amphetamine addiction	40/1177	91/7206	3.82125099311e-10
ko04720	Long-term potentiation	42/1177	99/7206	5.3757963887e-10
ko04360	Axon guidance	73/1177	233/7206	7.45259272958e-09
ko05203	Viral carcinogenesis	15/1177	277/7206	2.86988449083e-08
ko04970	Salivary secretion	37/1177	95/7206	1.27006366307e-07
ko04925	Aldosterone synthesis and secretion	39/1177	105/7206	1.82965687075e-07
ko04022	cGMP-PKG signaling pathway	64/1177	216/7206	7.89310702831e-07
ko04060	Cytokine-cytokine receptor interaction	9/1177	191/7206	8.29649690924e-07
ko05030	Cocaine addiction	29/1177	73/7206	1.35031257494e-06
ko03013	RNA transport	7/1177	166/7206	1.90723768401e-06
ko05168	Herpes simplex infection	9/1177	182/7206	3.42745073056e-06
ko04740	Olfactory transduction	30/1177	80/7206	4.26083119521e-06
ko04971	Gastric acid secretion	34/1177	98/7206	6.83138426597e-06
ko05322	Systemic lupus erythematosus	7/1177	151/7206	1.68376892651e-05
ko04610	Complement and coagulation cascades	1/1177	79/7206	2.0317451411e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1177	74/7206	2.17690388903e-05
ko04621	NOD-like receptor signaling pathway	8/1177	157/7206	2.53924515192e-05
ko04010	MAPK signaling pathway	81/1177	321/7206	2.75514381611e-05
ko04745	Phototransduction - fly	17/1177	38/7206	3.46321007875e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1177	79/7206	3.79755791403e-05
ko04966	Collecting duct acid secretion	13/1177	26/7206	7.05891142581e-05
ko04064	NF-kappa B signaling pathway	3/1177	96/7206	7.24291361847e-05
ko05414	Dilated cardiomyopathy	35/1177	112/7206	8.09785815929e-05
ko04070	Phosphatidylinositol signaling system	35/1177	112/7206	8.09785815929e-05
ko04141	Protein processing in endoplasmic reticulum	12/1177	184/7206	0.000103069687294
ko04072	Phospholipase D signaling pathway	53/1177	197/7206	0.000124351329617
ko04540	Gap junction	38/1177	128/7206	0.000144660227763
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko04514	Cell adhesion molecules (CAMs)	38/1177	130/7206	0.000178676372096
ko04924	Renin secretion	28/1177	86/7206	0.000179014784629
ko04120	Ubiquitin mediated proteolysis	8/1177	138/7206	0.000266923247157
ko05164	Influenza A	11/1177	167/7206	0.000270186237443
ko04730	Long-term depression	26/1177	78/7206	0.000275590374378
ko05169	Epstein-Barr virus infection	16/1177	206/7206	0.000366269962761
ko04972	Pancreatic secretion	33/1177	111/7206	0.000385906441282
ko05140	Leishmaniasis	2/1177	75/7206	0.000395931088136
ko05110	Vibrio cholerae infection	22/1177	63/7206	0.00040996559551
ko04260	Cardiac muscle contraction	30/1177	98/7206	0.000453567495838
ko05162	Measles	7/1177	120/7206	0.000703298764986
ko04371	Apelin signaling pathway	46/1177	177/7206	0.000903016898743
ko04110	Cell cycle	10/1177	145/7206	0.000928949476052
ko04626	Plant-pathogen interaction	9/1177	18/7206	0.000956805670149
ko04923	Regulation of lipolysis in adipocytes	24/1177	77/7206	0.00100308907976
ko04915	Estrogen signaling pathway	36/1177	131/7206	0.00113445874653
ko04014	Ras signaling pathway	66/1177	279/7206	0.00122397264075
ko04146	Peroxisome	4/1177	89/7206	0.00123489807589
ko00480	Glutathione metabolism	1/1177	55/7206	0.0013609955456
ko05205	Proteoglycans in cancer	26/1177	271/7206	0.00142497010212
ko00590	Arachidonic acid metabolism	1/1177	52/7206	0.0019981508444
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1177	59/7206	0.00223620792041
ko05161	Hepatitis B	14/1177	173/7206	0.00234242996201
ko00240	Pyrimidine metabolism	7/1177	110/7206	0.0025771359618
ko04750	Inflammatory mediator regulation of TRP channels	33/1177	122/7206	0.00272068278777
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1177	14/7206	0.00361649239703
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko04612	Antigen processing and presentation	4/1177	77/7206	0.0048470554631
ko04976	Bile secretion	23/1177	80/7206	0.00544496450997
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1177	100/7206	0.00605082405785
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko05144	Malaria	1/1177	45/7206	0.0069846573587
ko00071	Fatty acid degradation	1/1177	45/7206	0.0069846573587
ko01524	Platinum drug resistance	4/1177	76/7206	0.00710890695325
ko00562	Inositol phosphate metabolism	24/1177	89/7206	0.00918444143174
ko04640	Hematopoietic cell lineage	3/1177	64/7206	0.0095996163958
ko04214	Apoptosis - fly	4/1177	72/7206	0.00964489161724
ko04510	Focal adhesion	25/1177	240/7206	0.00990287531206
ko04916	Melanogenesis	35/1177	142/7206	0.0110780566361
ko04630	Jak-STAT signaling pathway	11/1177	132/7206	0.0119325471535
ko00380	Tryptophan metabolism	2/1177	50/7206	0.0121079992502
ko00330	Arginine and proline metabolism	3/1177	61/7206	0.013473283081
ko03320	PPAR signaling pathway	4/1177	69/7206	0.0134784831807
ko04930	Type II diabetes mellitus	16/1177	54/7206	0.0145191445536
ko00630	Glyoxylate and dicarboxylate metabolism	1/1177	38/7206	0.0148791725044
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1177	40/7206	0.0156894667357
ko03018	RNA degradation	6/1177	84/7206	0.0174592299189
ko04912	GnRH signaling pathway	30/1177	122/7206	0.0182150411488
ko04210	Apoptosis	18/1177	180/7206	0.0185391045197
ko04964	Proximal tubule bicarbonate reclamation	10/1177	29/7206	0.0188605537655
ko05145	Toxoplasmosis	11/1177	126/7206	0.0201018728243
ko00982	Drug metabolism - cytochrome P450	1/1177	37/7206	0.0228662800525
ko05131	Shigellosis	6/1177	82/7206	0.0236341544485
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1177	15/7206	0.0248481727437
ko00310	Lysine degradation	5/1177	73/7206	0.0251164518431
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko00620	Pyruvate metabolism	2/1177	46/7206	0.0257328571519
ko00280	Valine, leucine and isoleucine degradation	3/1177	54/7206	0.0264623290671
ko00270	Cysteine and methionine metabolism	2/1177	47/7206	0.0266675633818
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1177	26/7206	0.0275631788316
ko05222	Small cell lung cancer	7/1177	89/7206	0.0294733180324
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1177	92/7206	0.0320452617749
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1177	182/7206	0.032265844681
ko04670	Leukocyte transendothelial migration	15/1177	151/7206	0.0337758026822
ko04658	Th1 and Th2 cell differentiation	8/1177	96/7206	0.0358060328565
ko04622	RIG-I-like receptor signaling pathway	4/1177	62/7206	0.0366046709257
ko04114	Oocyte meiosis	32/1177	139/7206	0.0366670188485
ko00983	Drug metabolism - other enzymes	2/1177	42/7206	0.0367538774412
ko05215	Prostate cancer	10/1177	111/7206	0.0374718085476
ko04922	Glucagon signaling pathway	30/1177	128/7206	0.0391641705022
ko04722	Neurotrophin signaling pathway	36/1177	160/7206	0.0393505185532
ko04657	IL-17 signaling pathway	7/1177	87/7206	0.0395843801076
ko05133	Pertussis	7/1177	87/7206	0.0395843801076