ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1125	423/7206	1.81135411083e-56
ko05033	Nicotine addiction	47/1125	56/7206	9.78222437955e-30
ko04724	Glutamatergic synapse	82/1125	152/7206	2.20347416602e-28
ko05032	Morphine addiction	61/1125	110/7206	3.34402036356e-22
ko04721	Synaptic vesicle cycle	50/1125	80/7206	1.37085978926e-21
ko04713	Circadian entrainment	68/1125	136/7206	3.12382870078e-21
ko04727	GABAergic synapse	59/1125	110/7206	1.55737210772e-20
ko04728	Dopaminergic synapse	81/1125	185/7206	2.08279801713e-20
ko04024	cAMP signaling pathway	101/1125	279/7206	7.81086444784e-18
ko04725	Cholinergic synapse	70/1125	160/7206	9.37625959115e-18
ko04020	Calcium signaling pathway	96/1125	265/7206	5.78057411055e-17
ko04723	Retrograde endocannabinoid signaling	71/1125	175/7206	7.312350964e-16
ko04742	Taste transduction	37/1125	61/7206	1.11048335787e-15
ko04911	Insulin secretion	54/1125	117/7206	3.53628450986e-15
ko04726	Serotonergic synapse	56/1125	137/7206	6.32123634058e-13
ko04921	Oxytocin signaling pathway	74/1125	209/7206	9.56303159762e-13
ko04970	Salivary secretion	42/1125	95/7206	2.48846723314e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1125	205/7206	2.77757336355e-11
ko04360	Axon guidance	76/1125	233/7206	4.5169450106e-11
ko04720	Long-term potentiation	42/1125	99/7206	1.25081813235e-10
ko05031	Amphetamine addiction	39/1125	91/7206	4.01647494374e-10
ko03040	Spliceosome	1/1125	145/7206	8.41076123572e-10
ko05203	Viral carcinogenesis	12/1125	277/7206	3.05086552109e-09
ko04022	cGMP-PKG signaling pathway	66/1125	216/7206	1.87377155179e-08
ko04060	Cytokine-cytokine receptor interaction	6/1125	191/7206	4.18834234129e-08
ko05168	Herpes simplex infection	6/1125	182/7206	1.25719578427e-07
ko04744	Phototransduction	19/1125	36/7206	2.45746287526e-07
ko04971	Gastric acid secretion	36/1125	98/7206	2.8172297193e-07
ko05030	Cocaine addiction	29/1125	73/7206	5.13388395076e-07
ko05164	Influenza A	6/1125	167/7206	1.24750685122e-06
ko04120	Ubiquitin mediated proteolysis	4/1125	138/7206	2.26550943032e-06
ko04540	Gap junction	41/1125	128/7206	3.05865769621e-06
ko04925	Aldosterone synthesis and secretion	35/1125	105/7206	4.9126731438e-06
ko04740	Olfactory transduction	29/1125	80/7206	5.80382359143e-06
ko03013	RNA transport	7/1125	166/7206	6.25226024688e-06
ko04141	Protein processing in endoplasmic reticulum	9/1125	184/7206	7.31991404876e-06
ko05322	Systemic lupus erythematosus	6/1125	151/7206	7.42259936443e-06
ko04260	Cardiac muscle contraction	33/1125	98/7206	7.702513435e-06
ko04924	Renin secretion	30/1125	86/7206	8.24632870496e-06
ko04010	MAPK signaling pathway	80/1125	321/7206	9.15595269468e-06
ko04730	Long-term depression	28/1125	78/7206	1.00282428237e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1125	59/7206	1.12083525665e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1125	74/7206	1.18160296711e-05
ko04514	Cell adhesion molecules (CAMs)	40/1125	130/7206	1.27345610499e-05
ko04966	Collecting duct acid secretion	13/1125	26/7206	4.32648552353e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1125	79/7206	5.55109787873e-05
ko05169	Epstein-Barr virus infection	13/1125	206/7206	5.6085755922e-05
ko04976	Bile secretion	26/1125	80/7206	0.000140889958194
ko05110	Vibrio cholerae infection	22/1125	63/7206	0.000144682383164
ko04972	Pancreatic secretion	33/1125	111/7206	0.000167103156836
ko04621	NOD-like receptor signaling pathway	9/1125	157/7206	0.000206832783346
ko04610	Complement and coagulation cascades	2/1125	79/7206	0.000268226106197
ko03008	Ribosome biogenesis in eukaryotes	2/1125	79/7206	0.000268226106197
ko04745	Phototransduction - fly	15/1125	38/7206	0.000321575982698
ko04612	Antigen processing and presentation	2/1125	77/7206	0.000397610924029
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1125	14/7206	0.000427888990798
ko00240	Pyrimidine metabolism	5/1125	110/7206	0.000477933209297
ko05140	Leishmaniasis	2/1125	75/7206	0.000596449518547
ko04064	NF-kappa B signaling pathway	4/1125	96/7206	0.000607357648218
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1125	182/7206	0.000841828845297
ko05161	Hepatitis B	12/1125	173/7206	0.00090531871471
ko05414	Dilated cardiomyopathy	31/1125	112/7206	0.00092352272964
ko04014	Ras signaling pathway	64/1125	279/7206	0.000992912194176
ko05162	Measles	7/1125	120/7206	0.00141276424358
ko04146	Peroxisome	4/1125	89/7206	0.00176971050879
ko01200	Carbon metabolism	8/1125	128/7206	0.00192587739805
ko00480	Glutathione metabolism	1/1125	55/7206	0.00215501396606
ko04371	Apelin signaling pathway	43/1125	177/7206	0.00222795363936
ko04750	Inflammatory mediator regulation of TRP channels	32/1125	122/7206	0.0022905780253
ko04110	Cell cycle	10/1125	145/7206	0.00242128760174
ko04640	Hematopoietic cell lineage	2/1125	64/7206	0.00276998390955
ko04964	Proximal tubule bicarbonate reclamation	11/1125	29/7206	0.00292063675528
ko04978	Mineral absorption	14/1125	40/7206	0.003117114598
ko00590	Arachidonic acid metabolism	1/1125	52/7206	0.00316562351046
ko03018	RNA degradation	4/1125	84/7206	0.00359015260961
ko04072	Phospholipase D signaling pathway	46/1125	197/7206	0.00374959468096
ko04140	Autophagy - animal	13/1125	164/7206	0.00445414960793
ko04915	Estrogen signaling pathway	33/1125	131/7206	0.00477623747905
ko04214	Apoptosis - fly	3/1125	72/7206	0.00478828590299
ko04217	Necroptosis	15/1125	178/7206	0.0062573562044
ko00071	Fatty acid degradation	1/1125	45/7206	0.00685914065257
ko03420	Nucleotide excision repair	1/1125	46/7206	0.00691348508717
ko04630	Jak-STAT signaling pathway	10/1125	132/7206	0.00755121417458
ko04070	Phosphatidylinositol signaling system	28/1125	112/7206	0.0084449494495
ko05321	Inflammatory bowel disease (IBD)	2/1125	56/7206	0.00863533869528
ko04950	Maturity onset diabetes of the young	10/1125	29/7206	0.00968852974037
ko01524	Platinum drug resistance	4/1125	76/7206	0.0100607768176
ko05418	Fluid shear stress and atherosclerosis	15/1125	173/7206	0.0104745724344
ko03022	Basal transcription factors	1/1125	44/7206	0.0105603312529
ko04668	TNF signaling pathway	9/1125	120/7206	0.0108415285146
ko00280	Valine, leucine and isoleucine degradation	2/1125	54/7206	0.0127873282428
ko05145	Toxoplasmosis	10/1125	126/7206	0.0131669053115
ko05205	Proteoglycans in cancer	28/1125	271/7206	0.0132042540698
ko04622	RIG-I-like receptor signaling pathway	3/1125	62/7206	0.0135430718736
ko00561	Glycerolipid metabolism	3/1125	63/7206	0.0136051589131
ko05131	Shigellosis	5/1125	82/7206	0.0136901533972
ko00310	Lysine degradation	4/1125	73/7206	0.0139883274689
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1125	40/7206	0.0152814678664
ko04974	Protein digestion and absorption	24/1125	96/7206	0.0154280369795
ko04620	Toll-like receptor signaling pathway	7/1125	100/7206	0.0172631378231
ko00380	Tryptophan metabolism	2/1125	50/7206	0.0180437455651
ko04270	Vascular smooth muscle contraction	35/1125	154/7206	0.0180523581401
ko04916	Melanogenesis	33/1125	142/7206	0.0187372483924
ko00330	Arginine and proline metabolism	3/1125	61/7206	0.0195789903948
ko04930	Type II diabetes mellitus	15/1125	54/7206	0.0218399082133
ko04658	Th1 and Th2 cell differentiation	7/1125	96/7206	0.0226113409684
ko00982	Drug metabolism - cytochrome P450	1/1125	37/7206	0.0227792491382
ko04657	IL-17 signaling pathway	6/1125	87/7206	0.0245315574169
ko05133	Pertussis	6/1125	87/7206	0.0245315574169
ko00270	Cysteine and methionine metabolism	2/1125	47/7206	0.026043011534
ko00020	Citrate cycle (TCA cycle)	1/1125	35/7206	0.033890477818
ko04115	p53 signaling pathway	5/1125	74/7206	0.0351283627895
ko05144	Malaria	2/1125	45/7206	0.0376254623303
ko04923	Regulation of lipolysis in adipocytes	19/1125	77/7206	0.03840131696
ko04015	Rap1 signaling pathway	56/1125	278/7206	0.0426065432354
ko04626	Plant-pathogen interaction	6/1125	18/7206	0.049478461512