ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 106/585 423/7206 4.72911205692e-28 ko04724 Glutamatergic synapse 52/585 152/7206 1.92256830971e-20 ko04727 GABAergic synapse 42/585 110/7206 9.4347330003e-19 ko05033 Nicotine addiction 29/585 56/7206 1.11575117366e-17 ko05032 Morphine addiction 40/585 110/7206 4.93266423977e-17 ko04713 Circadian entrainment 43/585 136/7206 1.19369222078e-15 ko04723 Retrograde endocannabinoid signaling 46/585 175/7206 2.5558176695e-13 ko04020 Calcium signaling pathway 59/585 265/7206 2.74411388796e-13 ko04728 Dopaminergic synapse 46/585 185/7206 2.2333377717e-12 ko05031 Amphetamine addiction 28/585 91/7206 2.62825670534e-10 ko04024 cAMP signaling pathway 55/585 279/7206 3.18574999213e-10 ko04726 Serotonergic synapse 33/585 137/7206 7.53927978357e-09 ko04921 Oxytocin signaling pathway 42/585 209/7206 2.26014435687e-08 ko04720 Long-term potentiation 26/585 99/7206 4.61016078149e-08 ko04725 Cholinergic synapse 34/585 160/7206 1.2585482298e-07 ko04911 Insulin secretion 27/585 117/7206 4.52227706702e-07 ko04742 Taste transduction 18/585 61/7206 8.63289387166e-07 ko04070 Phosphatidylinositol signaling system 25/585 112/7206 2.32392729013e-06 ko04925 Aldosterone synthesis and secretion 24/585 105/7206 2.36915218731e-06 ko04261 Adrenergic signaling in cardiomyocytes 37/585 205/7206 2.97779631978e-06 ko05030 Cocaine addiction 19/585 73/7206 3.5082414459e-06 ko04721 Synaptic vesicle cycle 20/585 80/7206 3.83180985952e-06 ko04010 MAPK signaling pathway 50/585 321/7206 5.14096853283e-06 ko04730 Long-term depression 19/585 78/7206 1.0055741822e-05 ko04022 cGMP-PKG signaling pathway 36/585 216/7206 3.46646615535e-05 ko04970 Salivary secretion 20/585 95/7206 5.82228167119e-05 ko04930 Type II diabetes mellitus 14/585 54/7206 7.09798295094e-05 ko04072 Phospholipase D signaling pathway 31/585 197/7206 0.000292250248916 ko03010 Ribosome 1/585 129/7206 0.000450664485759 ko03013 RNA transport 3/585 166/7206 0.000803835590658 ko04141 Protein processing in endoplasmic reticulum 4/585 184/7206 0.000931749696159 ko04110 Cell cycle 2/585 145/7206 0.000974077544525 ko05231 Choline metabolism in cancer 22/585 134/7206 0.00120285223933 ko04710 Circadian rhythm 10/585 43/7206 0.00189057749356 ko04972 Pancreatic secretion 19/585 111/7206 0.00222410082681 ko04060 Cytokine-cytokine receptor interaction 5/585 191/7206 0.00276610517174 ko04071 Sphingolipid signaling pathway 24/585 162/7206 0.00333587594213 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/585 14/7206 0.00373786093423 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/585 79/7206 0.00530996731343 ko00562 Inositol phosphate metabolism 15/585 89/7206 0.00546267377418 ko04666 Fc gamma R-mediated phagocytosis 19/585 122/7206 0.00632851841031 ko05203 Viral carcinogenesis 11/585 277/7206 0.00692777897767 ko04260 Cardiac muscle contraction 16/585 98/7206 0.00749460332585 ko05014 Amyotrophic lateral sclerosis (ALS) 13/585 74/7206 0.00787376183659 ko05202 Transcriptional misregulation in cancer 6/585 188/7206 0.00944513569668 ko05322 Systemic lupus erythematosus 4/585 151/7206 0.0095686787562 ko04014 Ras signaling pathway 35/585 279/7206 0.00959888671259 ko00250 Alanine, aspartate and glutamate metabolism 8/585 38/7206 0.00992331979671 ko04745 Phototransduction - fly 8/585 38/7206 0.00992331979671 ko04750 Inflammatory mediator regulation of TRP channels 18/585 122/7206 0.0113522463364 ko04514 Cell adhesion molecules (CAMs) 19/585 130/7206 0.0134868849604 ko04924 Renin secretion 14/585 86/7206 0.0145960882571 ko04711 Circadian rhythm - fly 4/585 13/7206 0.0169970603383 ko00680 Methane metabolism 7/585 34/7206 0.017479416668 ko05169 Epstein-Barr virus infection 8/585 206/7206 0.0195612163006 ko04540 Gap junction 18/585 128/7206 0.0206220786333 ko00430 Taurine and hypotaurine metabolism 4/585 14/7206 0.0223007400999 ko05414 Dilated cardiomyopathy 16/585 112/7206 0.02249326026 ko04915 Estrogen signaling pathway 18/585 131/7206 0.023257172243 ko05168 Herpes simplex infection 7/585 182/7206 0.0277310127198 ko04270 Vascular smooth muscle contraction 20/585 154/7206 0.0351132748369 ko02010 ABC transporters 7/585 39/7206 0.0352301713623 ko00471 D-Glutamine and D-glutamate metabolism 2/585 4/7206 0.0353502531738 ko04740 Olfactory transduction 12/585 80/7206 0.0359033104036 ko05230 Central carbon metabolism in cancer 12/585 81/7206 0.0377068649353 ko04145 Phagosome 6/585 162/7206 0.039968755307 ko05410 Hypertrophic cardiomyopathy (HCM) 14/585 100/7206 0.040315951808 ko04960 Aldosterone-regulated sodium reabsorption 7/585 41/7206 0.0448134911143 ko04371 Apelin signaling pathway 22/585 177/7206 0.0491230210878 ko00010 Glycolysis / Gluconeogenesis 11/585 74/7206 0.0493126874829