ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 37/340 79/7206 9.64597034855e-29 ko04975 Fat digestion and absorption 18/340 35/7206 1.88414340651e-15 ko04974 Protein digestion and absorption 22/340 96/7206 3.70899850569e-10 ko04977 Vitamin digestion and absorption 10/340 22/7206 1.86887640528e-08 ko00260 Glycine, serine and threonine metabolism 14/340 48/7206 2.32573507836e-08 ko04950 Maturity onset diabetes of the young 11/340 29/7206 3.53848448191e-08 ko05150 Staphylococcus aureus infection 11/340 36/7206 4.55920908028e-07 ko04978 Mineral absorption 11/340 40/7206 1.47955999436e-06 ko00983 Drug metabolism - other enzymes 11/340 42/7206 2.51607075799e-06 ko04614 Renin-angiotensin system 7/340 18/7206 9.92444147952e-06 ko05166 HTLV-I infection 1/340 292/7206 1.49995587258e-05 ko04973 Carbohydrate digestion and absorption 10/340 42/7206 1.82356807747e-05 ko04976 Bile secretion 14/340 80/7206 1.83603753454e-05 ko00100 Steroid biosynthesis 7/340 21/7206 3.20631526815e-05 ko00591 Linoleic acid metabolism 7/340 22/7206 4.51381175474e-05 ko03320 PPAR signaling pathway 12/340 69/7206 7.76182669404e-05 ko00980 Metabolism of xenobiotics by cytochrome P450 9/340 40/7206 7.77263551661e-05 ko00590 Arachidonic acid metabolism 10/340 52/7206 0.000128645899294 ko00040 Pentose and glucuronate interconversions 7/340 26/7206 0.000147822109827 ko04216 Ferroptosis 9/340 44/7206 0.000170513739631 ko04360 Axon guidance 1/340 233/7206 0.00023105101978 ko05200 Pathways in cancer 8/340 492/7206 0.000243961456236 ko00270 Cysteine and methionine metabolism 9/340 47/7206 0.000289207576035 ko01200 Carbon metabolism 16/340 128/7206 0.000316915710782 ko00630 Glyoxylate and dicarboxylate metabolism 8/340 38/7206 0.000318765063494 ko05204 Chemical carcinogenesis 9/340 48/7206 0.000341422933138 ko04144 Endocytosis 4/340 342/7206 0.000369626932048 ko05016 Huntington's disease 1/340 215/7206 0.000499530150219 ko00330 Arginine and proline metabolism 10/340 61/7206 0.000502527518506 ko04972 Pancreatic secretion 14/340 111/7206 0.000679070373749 ko04010 MAPK signaling pathway 4/340 321/7206 0.00104241715478 ko05034 Alcoholism 2/340 238/7206 0.00152656365713 ko04964 Proximal tubule bicarbonate reclamation 6/340 29/7206 0.00199243982942 ko01230 Biosynthesis of amino acids 11/340 85/7206 0.00203605957255 ko04141 Protein processing in endoplasmic reticulum 1/340 184/7206 0.00229908672589 ko00140 Steroid hormone biosynthesis 7/340 41/7206 0.00274629750667 ko04146 Peroxisome 11/340 89/7206 0.00294682923057 ko00830 Retinol metabolism 7/340 42/7206 0.00316507762396 ko04217 Necroptosis 1/340 178/7206 0.00341880078365 ko00480 Glutathione metabolism 8/340 55/7206 0.00394865556512 ko05010 Alzheimer's disease 2/340 202/7206 0.00625896391611 ko05169 Epstein-Barr virus infection 2/340 206/7206 0.00652757372528 ko04621 NOD-like receptor signaling pathway 1/340 157/7206 0.00705730937671 ko00982 Drug metabolism - cytochrome P450 6/340 37/7206 0.00710043889423 ko05133 Pertussis 10/340 87/7206 0.00754259321654 ko00250 Alanine, aspartate and glutamate metabolism 6/340 38/7206 0.00810541059868 ko02010 ABC transporters 6/340 39/7206 0.00920872800239 ko00592 alpha-Linolenic acid metabolism 4/340 19/7206 0.0107439896943 ko00120 Primary bile acid biosynthesis 4/340 20/7206 0.0129407865848 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/340 11/7206 0.0129453830442 ko00565 Ether lipid metabolism 6/340 42/7206 0.0131574972191 ko04080 Neuroactive ligand-receptor interaction 10/340 423/7206 0.0173202419503 ko00053 Ascorbate and aldarate metabolism 4/340 22/7206 0.018144226866 ko04922 Glucagon signaling pathway 12/340 128/7206 0.0193019310166 ko00472 D-Arginine and D-ornithine metabolism 2/340 5/7206 0.0201888913148 ko00232 Caffeine metabolism 2/340 5/7206 0.0201888913148 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/340 5/7206 0.0201888913148 ko00311 Penicillin and cephalosporin biosynthesis 2/340 5/7206 0.0201888913148 ko00860 Porphyrin and chlorophyll metabolism 5/340 34/7206 0.0204727151577 ko04630 Jak-STAT signaling pathway 1/340 132/7206 0.0214255563722 ko00010 Glycolysis / Gluconeogenesis 8/340 74/7206 0.0226090846072 ko00020 Citrate cycle (TCA cycle) 5/340 35/7206 0.02299059685 ko00500 Starch and sucrose metabolism 5/340 35/7206 0.02299059685 ko04152 AMPK signaling pathway 14/340 161/7206 0.0230474677201 ko00770 Pantothenate and CoA biosynthesis 3/340 14/7206 0.0257167062763 ko00564 Glycerophospholipid metabolism 10/340 99/7206 0.0259713512091 ko04062 Chemokine signaling pathway 3/340 201/7206 0.0263614316985 ko00561 Glycerolipid metabolism 7/340 63/7206 0.0280051563125 ko00340 Histidine metabolism 4/340 25/7206 0.0280945475923 ko00380 Tryptophan metabolism 6/340 50/7206 0.0291478641618 ko04666 Fc gamma R-mediated phagocytosis 1/340 122/7206 0.0308722221575 ko04660 T cell receptor signaling pathway 1/340 124/7206 0.0309328614448 ko04931 Insulin resistance 12/340 137/7206 0.0378431064752 ko05020 Prion diseases 5/340 40/7206 0.0385379000198 ko05203 Viral carcinogenesis 6/340 277/7206 0.0416409796048 ko04015 Rap1 signaling pathway 6/340 278/7206 0.0418015521459 ko00720 Carbon fixation pathways in prokaryotes 3/340 17/7206 0.0432975916406 ko00360 Phenylalanine metabolism 3/340 17/7206 0.0432975916406 ko00520 Amino sugar and nucleotide sugar metabolism 6/340 55/7206 0.0437930620761 ko04013 MAPK signaling pathway - fly 1/340 115/7206 0.0444430752902 ko05162 Measles 1/340 120/7206 0.0460709205 ko00051 Fructose and mannose metabolism 5/340 42/7206 0.046194153533 ko00401 Novobiocin biosynthesis 1/340 1/7206 0.0471829031365 ko04921 Oxytocin signaling pathway 4/340 209/7206 0.0471858831222 ko04150 mTOR signaling pathway 3/340 184/7206 0.0497897313081