ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	147/956	423/7206	1.10225181212e-31
ko04724	Glutamatergic synapse	78/956	152/7206	5.16070916792e-30
ko05032	Morphine addiction	60/956	110/7206	3.83476854147e-25
ko05033	Nicotine addiction	41/956	56/7206	1.11727151739e-24
ko04713	Circadian entrainment	64/956	136/7206	3.94522622449e-22
ko04721	Synaptic vesicle cycle	46/956	80/7206	8.16611455059e-21
ko04727	GABAergic synapse	55/956	110/7206	9.64103563297e-21
ko04728	Dopaminergic synapse	74/956	185/7206	3.34000454918e-20
ko04723	Retrograde endocannabinoid signaling	69/956	175/7206	1.68679241169e-18
ko04725	Cholinergic synapse	63/956	160/7206	5.9991492212e-17
ko04024	cAMP signaling pathway	87/956	279/7206	1.71214812173e-15
ko04921	Oxytocin signaling pathway	67/956	209/7206	8.80890076777e-13
ko04911	Insulin secretion	46/956	117/7206	1.13489674306e-12
ko04261	Adrenergic signaling in cardiomyocytes	64/956	205/7206	1.45530449857e-11
ko04020	Calcium signaling pathway	75/956	265/7206	5.8167404522e-11
ko04726	Serotonergic synapse	47/956	137/7206	1.76578026441e-10
ko04742	Taste transduction	28/956	61/7206	4.57478630163e-10
ko05031	Amphetamine addiction	35/956	91/7206	1.20066847626e-09
ko04744	Phototransduction	19/956	36/7206	1.67824317276e-08
ko03040	Spliceosome	1/956	145/7206	3.63625116731e-08
ko04720	Long-term potentiation	34/956	99/7206	5.86753183539e-08
ko05203	Viral carcinogenesis	11/956	277/7206	1.81166826424e-07
ko04970	Salivary secretion	32/956	95/7206	2.3981894489e-07
ko04925	Aldosterone synthesis and secretion	34/956	105/7206	2.96529066963e-07
ko05322	Systemic lupus erythematosus	3/956	151/7206	1.38912659804e-06
ko05030	Cocaine addiction	25/956	73/7206	3.53295678125e-06
ko04360	Axon guidance	56/956	233/7206	7.34977856249e-06
ko05164	Influenza A	5/956	167/7206	7.8828357405e-06
ko04060	Cytokine-cytokine receptor interaction	7/956	191/7206	1.10040208038e-05
ko04971	Gastric acid secretion	29/956	98/7206	1.6854332198e-05
ko04621	NOD-like receptor signaling pathway	5/956	157/7206	2.32522951301e-05
ko04022	cGMP-PKG signaling pathway	51/956	216/7206	2.43824392439e-05
ko05168	Herpes simplex infection	7/956	182/7206	3.15507415564e-05
ko04514	Cell adhesion molecules (CAMs)	35/956	130/7206	3.41252235895e-05
ko03013	RNA transport	6/956	166/7206	3.88086402444e-05
ko04120	Ubiquitin mediated proteolysis	4/956	138/7206	3.94460637232e-05
ko04966	Collecting duct acid secretion	12/956	26/7206	4.47695195667e-05
ko04972	Pancreatic secretion	31/956	111/7206	4.96057837573e-05
ko04010	MAPK signaling pathway	68/956	321/7206	6.6208680038e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/956	79/7206	0.000168526252784
ko05014	Amyotrophic lateral sclerosis (ALS)	22/956	74/7206	0.000179472190339
ko04745	Phototransduction - fly	14/956	38/7206	0.000208229001677
ko05169	Epstein-Barr virus infection	11/956	206/7206	0.000238943548175
ko04141	Protein processing in endoplasmic reticulum	9/956	184/7206	0.000243455554411
ko04610	Complement and coagulation cascades	1/956	79/7206	0.000318393712845
ko05414	Dilated cardiomyopathy	29/956	112/7206	0.000336273050568
ko05162	Measles	4/956	120/7206	0.000346769198592
ko04014	Ras signaling pathway	58/956	279/7206	0.000404046899101
ko04260	Cardiac muscle contraction	26/956	98/7206	0.000418050962283
ko04110	Cell cycle	6/956	145/7206	0.000440045739526
ko04070	Phosphatidylinositol signaling system	28/956	112/7206	0.000649448556431
ko04924	Renin secretion	23/956	86/7206	0.000670432357607
ko04072	Phospholipase D signaling pathway	43/956	197/7206	0.000854902057175
ko05161	Hepatitis B	9/956	173/7206	0.000875858874765
ko05215	Prostate cancer	4/956	111/7206	0.00100644573067
ko04915	Estrogen signaling pathway	31/956	131/7206	0.00101125060264
ko04730	Long-term depression	21/956	78/7206	0.00112456884973
ko05110	Vibrio cholerae infection	18/956	63/7206	0.00113259629118
ko04064	NF-kappa B signaling pathway	3/956	96/7206	0.00124819676449
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/956	59/7206	0.00146454666129
ko04612	Antigen processing and presentation	2/956	77/7206	0.00213786797726
ko03008	Ribosome biogenesis in eukaryotes	2/956	79/7206	0.00218980865676
ko05205	Proteoglycans in cancer	20/956	271/7206	0.00249113619878
ko04750	Inflammatory mediator regulation of TRP channels	28/956	122/7206	0.00284185260315
ko04964	Proximal tubule bicarbonate reclamation	10/956	29/7206	0.00297001272363
ko05140	Leishmaniasis	2/956	75/7206	0.00312222056246
ko04217	Necroptosis	11/956	178/7206	0.00337595788092
ko04630	Jak-STAT signaling pathway	7/956	132/7206	0.00410320838292
ko04740	Olfactory transduction	20/956	80/7206	0.00416942984507
ko04976	Bile secretion	20/956	80/7206	0.00416942984507
ko04214	Apoptosis - fly	2/956	72/7206	0.00454239298041
ko04371	Apelin signaling pathway	37/956	177/7206	0.0046787743868
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/956	14/7206	0.00624253630539
ko04510	Focal adhesion	18/956	240/7206	0.00644346514979
ko05410	Hypertrophic cardiomyopathy (HCM)	23/956	100/7206	0.00692053946842
ko04922	Glucagon signaling pathway	28/956	128/7206	0.00786149993873
ko04540	Gap junction	28/956	128/7206	0.00786149993873
ko00520	Amino sugar and nucleotide sugar metabolism	1/956	55/7206	0.00790184323606
ko00480	Glutathione metabolism	1/956	55/7206	0.00790184323606
ko05166	HTLV-I infection	24/956	292/7206	0.00804952662533
ko00240	Pyrimidine metabolism	6/956	110/7206	0.0105982968692
ko04146	Peroxisome	4/956	89/7206	0.010973242273
ko00590	Arachidonic acid metabolism	1/956	52/7206	0.0117414144019
ko04930	Type II diabetes mellitus	14/956	54/7206	0.0132575545721
ko04330	Notch signaling pathway	2/956	62/7206	0.0136242826516
ko04210	Apoptosis	13/956	180/7206	0.0138943658637
ko00310	Lysine degradation	3/956	73/7206	0.0147642936808
ko04657	IL-17 signaling pathway	4/956	87/7206	0.0156426796416
ko04923	Regulation of lipolysis in adipocytes	18/956	77/7206	0.0162969675586
ko05219	Bladder cancer	1/956	48/7206	0.0168538266409
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/956	92/7206	0.0203311543701
ko04710	Circadian rhythm	11/956	43/7206	0.023839817766
ko04626	Plant-pathogen interaction	6/956	18/7206	0.024205629599
ko03022	Basal transcription factors	1/956	44/7206	0.024580544412
ko05144	Malaria	1/956	45/7206	0.0249387580883
ko00071	Fatty acid degradation	1/956	45/7206	0.0249387580883
ko03420	Nucleotide excision repair	1/956	46/7206	0.0257936361802
ko05321	Inflammatory bowel disease (IBD)	2/956	56/7206	0.0281162833989
ko05217	Basal cell carcinoma	3/956	68/7206	0.0293750813441
ko00140	Steroid hormone biosynthesis	1/956	41/7206	0.0362393140058
ko00680	Methane metabolism	9/956	34/7206	0.0371675896023
ko00562	Inositol phosphate metabolism	19/956	89/7206	0.0388314521412
ko01524	Platinum drug resistance	4/956	76/7206	0.0397078218796
ko00280	Valine, leucine and isoleucine degradation	2/956	54/7206	0.0409952586584
ko05145	Toxoplasmosis	9/956	126/7206	0.0455598856535
ko04152	AMPK signaling pathway	30/956	161/7206	0.0459777298598
ko04140	Autophagy - animal	13/956	164/7206	0.0466903134421
ko00512	Mucin type O-glycan biosynthesis	8/956	29/7206	0.0468634916753
ko04658	Th1 and Th2 cell differentiation	6/956	96/7206	0.0471041411554
ko04015	Rap1 signaling pathway	48/956	278/7206	0.0474918687693
ko04962	Vasopressin-regulated water reabsorption	13/956	58/7206	0.0499054331388