ko pathway ratio_in_study ratio_in_pop p_value ko03440 Homologous recombination 17/244 41/7206 4.26853418982e-15 ko03460 Fanconi anemia pathway 16/244 51/7206 4.56219705674e-12 ko03040 Spliceosome 25/244 145/7206 1.09213805937e-11 ko04110 Cell cycle 25/244 145/7206 1.09213805937e-11 ko04111 Cell cycle - yeast 18/244 90/7206 7.87690023324e-10 ko03030 DNA replication 11/244 38/7206 2.87147251295e-08 ko03410 Base excision repair 10/244 38/7206 3.38001652331e-07 ko03013 RNA transport 20/244 166/7206 6.88418977666e-07 ko00310 Lysine degradation 13/244 73/7206 7.89673050082e-07 ko00240 Pyrimidine metabolism 15/244 110/7206 3.81229051215e-06 ko03420 Nucleotide excision repair 9/244 46/7206 1.85827827121e-05 ko04113 Meiosis - yeast 11/244 70/7206 1.97753792173e-05 ko03018 RNA degradation 12/244 84/7206 2.24680024164e-05 ko04144 Endocytosis 1/244 342/7206 0.000161359758211 ko04151 PI3K-Akt signaling pathway 2/244 390/7206 0.000239341543421 ko03430 Mismatch repair 5/244 22/7206 0.000701164953991 ko04330 Notch signaling pathway 8/244 62/7206 0.0010707670278 ko03015 mRNA surveillance pathway 10/244 93/7206 0.00112615073746 ko05166 HTLV-I infection 21/244 292/7206 0.00126172856603 ko04020 Calcium signaling pathway 1/244 265/7206 0.00159344735596 ko04914 Progesterone-mediated oocyte maturation 10/244 104/7206 0.00262994209009 ko04115 p53 signaling pathway 8/244 74/7206 0.00336977063747 ko04114 Oocyte meiosis 11/244 139/7206 0.00733994830331 ko04530 Tight junction 1/244 228/7206 0.00762532540413 ko05202 Transcriptional misregulation in cancer 13/244 188/7206 0.0126143151989 ko03022 Basal transcription factors 5/244 44/7206 0.0158087400887 ko04261 Adrenergic signaling in cardiomyocytes 1/244 205/7206 0.0160833431577 ko05203 Viral carcinogenesis 17/244 277/7206 0.0162795456017 ko03008 Ribosome biogenesis in eukaryotes 7/244 79/7206 0.0171150815132 ko04510 Focal adhesion 2/244 240/7206 0.0178044348878 ko05206 MicroRNAs in cancer 12/244 177/7206 0.0188541751423 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/244 182/7206 0.0218327943094 ko04728 Dopaminergic synapse 1/244 185/7206 0.0218888958613 ko04010 MAPK signaling pathway 4/244 321/7206 0.0259917831951 ko04015 Rap1 signaling pathway 3/244 278/7206 0.0263287939842 ko04024 cAMP signaling pathway 3/244 279/7206 0.0264252953008 ko04014 Ras signaling pathway 3/244 279/7206 0.0264252953008 ko04910 Insulin signaling pathway 1/244 172/7206 0.031467604405 ko04723 Retrograde endocannabinoid signaling 1/244 175/7206 0.0317481878133 ko04371 Apelin signaling pathway 1/244 177/7206 0.0321076403956 ko05168 Herpes simplex infection 12/244 182/7206 0.0336090433264 ko04022 cGMP-PKG signaling pathway 2/244 216/7206 0.0351291102776 ko04139 Mitophagy - yeast 4/244 37/7206 0.0353121960391 ko04725 Cholinergic synapse 1/244 160/7206 0.0452146923493 ko04152 AMPK signaling pathway 1/244 161/7206 0.0452956449252 ko04140 Autophagy - animal 1/244 164/7206 0.0458200455836 ko04921 Oxytocin signaling pathway 2/244 209/7206 0.0495529323434