ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 45/359 191/7206 3.22097063353e-19 ko04621 NOD-like receptor signaling pathway 33/359 157/7206 7.87953246134e-13 ko05164 Influenza A 34/359 167/7206 9.17320917374e-13 ko04380 Osteoclast differentiation 30/359 134/7206 1.62731886157e-12 ko05340 Primary immunodeficiency 15/359 30/7206 1.69997341239e-12 ko05162 Measles 28/359 120/7206 3.1705596196e-12 ko04650 Natural killer cell mediated cytotoxicity 25/359 97/7206 4.50224168144e-12 ko05152 Tuberculosis 34/359 187/7206 2.60454948535e-11 ko05140 Leishmaniasis 21/359 75/7206 4.40269862206e-11 ko05168 Herpes simplex infection 33/359 182/7206 5.61378763281e-11 ko04217 Necroptosis 32/359 178/7206 1.40675284657e-10 ko05145 Toxoplasmosis 26/359 126/7206 3.61622751349e-10 ko05321 Inflammatory bowel disease (IBD) 17/359 56/7206 8.12555059984e-10 ko04064 NF-kappa B signaling pathway 22/359 96/7206 1.0478444154e-09 ko05320 Autoimmune thyroid disease 12/359 29/7206 4.69218230515e-09 ko05330 Allograft rejection 11/359 24/7206 5.61153965e-09 ko04659 Th17 cell differentiation 22/359 106/7206 7.63057624312e-09 ko05150 Staphylococcus aureus infection 13/359 36/7206 7.64503521776e-09 ko04620 Toll-like receptor signaling pathway 21/359 100/7206 1.35295094533e-08 ko04630 Jak-STAT signaling pathway 24/359 132/7206 2.46748936221e-08 ko04612 Antigen processing and presentation 18/359 77/7206 2.57005675137e-08 ko05332 Graft-versus-host disease 9/359 18/7206 5.58475476139e-08 ko04660 T cell receptor signaling pathway 22/359 124/7206 1.50966203201e-07 ko04658 Th1 and Th2 cell differentiation 18/359 96/7206 8.9861732764e-07 ko04672 Intestinal immune network for IgA production 11/359 37/7206 1.06862266171e-06 ko04062 Chemokine signaling pathway 26/359 201/7206 6.36259771881e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/359 191/7206 7.79362716556e-06 ko04640 Hematopoietic cell lineage 13/359 64/7206 1.21718121423e-05 ko04940 Type I diabetes mellitus 9/359 32/7206 1.72806192634e-05 ko04662 B cell receptor signaling pathway 15/359 88/7206 2.45284137588e-05 ko04610 Complement and coagulation cascades 14/359 79/7206 2.91074757712e-05 ko05161 Hepatitis B 22/359 173/7206 4.33124722898e-05 ko04622 RIG-I-like receptor signaling pathway 12/359 62/7206 4.38518943108e-05 ko04145 Phagosome 21/359 162/7206 4.8569064129e-05 ko05144 Malaria 10/359 45/7206 5.541726888e-05 ko05142 Chagas disease (American trypanosomiasis) 18/359 130/7206 7.07542308931e-05 ko05133 Pertussis 14/359 87/7206 8.79977257731e-05 ko05034 Alcoholism 1/359 238/7206 0.000106231710873 ko05323 Rheumatoid arthritis 14/359 89/7206 0.000113411599904 ko05310 Asthma 6/359 17/7206 0.000113606869626 ko03050 Proteasome 10/359 54/7206 0.000278450014867 ko00120 Primary bile acid biosynthesis 6/359 20/7206 0.000313218227793 ko04623 Cytosolic DNA-sensing pathway 8/359 41/7206 0.000788895353234 ko00590 Arachidonic acid metabolism 9/359 52/7206 0.000937090748336 ko04310 Wnt signaling pathway 1/359 181/7206 0.00155703830986 ko05160 Hepatitis C 17/359 153/7206 0.0018826193938 ko04666 Fc gamma R-mediated phagocytosis 14/359 122/7206 0.00286143313913 ko04514 Cell adhesion molecules (CAMs) 15/359 130/7206 0.00316698426835 ko00980 Metabolism of xenobiotics by cytochrome P450 7/359 40/7206 0.00322137315805 ko04664 Fc epsilon RI signaling pathway 10/359 77/7206 0.00461616580745 ko04152 AMPK signaling pathway 1/359 161/7206 0.00496755207644 ko04530 Tight junction 3/359 228/7206 0.00498762797544 ko04360 Axon guidance 3/359 233/7206 0.00513055324287 ko05416 Viral myocarditis 8/359 55/7206 0.00547913991297 ko04390 Hippo signaling pathway 2/359 188/7206 0.00616315999286 ko05204 Chemical carcinogenesis 7/359 48/7206 0.00904933841252 ko04611 Platelet activation 16/359 163/7206 0.00918687724601 ko00982 Drug metabolism - cytochrome P450 6/359 37/7206 0.00918729433174 ko05132 Salmonella infection 11/359 98/7206 0.00919898442681 ko03040 Spliceosome 1/359 145/7206 0.010470067284 ko05224 Breast cancer 2/359 174/7206 0.0124479785564 ko04210 Apoptosis 17/359 180/7206 0.0132771932385 ko04020 Calcium signaling pathway 5/359 265/7206 0.0137971526867 ko04713 Circadian entrainment 1/359 136/7206 0.0149985496501 ko04550 Signaling pathways regulating pluripotency of stem cells 2/359 165/7206 0.0175225615357 ko04668 TNF signaling pathway 12/359 120/7206 0.018095512551 ko00480 Glutathione metabolism 7/359 55/7206 0.0185494773403 ko01200 Carbon metabolism 1/359 128/7206 0.0216838039934 ko04142 Lysosome 14/359 151/7206 0.0217515561783 ko03010 Ribosome 1/359 129/7206 0.0219161652649 ko05146 Amoebiasis 10/359 99/7206 0.0311873948251 ko05418 Fluid shear stress and atherosclerosis 15/359 173/7206 0.0322630071104 ko04510 Focal adhesion 5/359 240/7206 0.03347730718 ko05169 Epstein-Barr virus infection 17/359 206/7206 0.0344891483366 ko04724 Glutamatergic synapse 2/359 152/7206 0.0353347743656 ko04270 Vascular smooth muscle contraction 2/359 154/7206 0.0361086327458 ko05016 Huntington's disease 4/359 215/7206 0.0361889147083 ko04080 Neuroactive ligand-receptor interaction 12/359 423/7206 0.0373043154976 ko00511 Other glycan degradation 4/359 26/7206 0.0380136543827 ko04114 Oocyte meiosis 2/359 139/7206 0.0482560953039 ko04910 Insulin signaling pathway 3/359 172/7206 0.0489588527046 ko00966 Glucosinolate biosynthesis 1/359 1/7206 0.0498195947821