ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1081	423/7206	4.81236590684e-52
ko05033	Nicotine addiction	44/1081	56/7206	2.35921385673e-26
ko04724	Glutamatergic synapse	75/1081	152/7206	5.78396998796e-24
ko04721	Synaptic vesicle cycle	49/1081	80/7206	2.10913694218e-21
ko04713	Circadian entrainment	64/1081	136/7206	3.1646081433e-19
ko04728	Dopaminergic synapse	75/1081	185/7206	1.12138579103e-17
ko04020	Calcium signaling pathway	95/1081	265/7206	1.29406276469e-17
ko04727	GABAergic synapse	52/1081	110/7206	6.03052495027e-16
ko05032	Morphine addiction	52/1081	110/7206	6.03052495027e-16
ko04921	Oxytocin signaling pathway	78/1081	209/7206	6.75690507567e-16
ko04725	Cholinergic synapse	65/1081	160/7206	1.60874056593e-15
ko04911	Insulin secretion	52/1081	117/7206	1.47435023285e-14
ko04024	cAMP signaling pathway	92/1081	279/7206	1.48494133879e-14
ko04723	Retrograde endocannabinoid signaling	66/1081	175/7206	7.07095736465e-14
ko04261	Adrenergic signaling in cardiomyocytes	72/1081	205/7206	4.08622835646e-13
ko04726	Serotonergic synapse	52/1081	137/7206	2.56193625534e-11
ko04742	Taste transduction	30/1081	61/7206	2.78474230854e-10
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	33/1081	79/7206	7.07240036215e-09
ko05031	Amphetamine addiction	36/1081	91/7206	8.4648162229e-09
ko04970	Salivary secretion	37/1081	95/7206	8.69068559879e-09
ko05203	Viral carcinogenesis	12/1081	277/7206	1.40562345121e-08
ko04260	Cardiac muscle contraction	37/1081	98/7206	2.32255346e-08
ko03040	Spliceosome	2/1081	145/7206	2.60134265835e-08
ko04022	cGMP-PKG signaling pathway	64/1081	216/7206	3.03997656918e-08
ko05168	Herpes simplex infection	5/1081	182/7206	7.18846651779e-08
ko04720	Long-term potentiation	36/1081	99/7206	1.1030954526e-07
ko04060	Cytokine-cytokine receptor interaction	7/1081	191/7206	5.1375427383e-07
ko04010	MAPK signaling pathway	82/1081	321/7206	5.27382732788e-07
ko04966	Collecting duct acid secretion	15/1081	26/7206	6.0413710673e-07
ko04120	Ubiquitin mediated proteolysis	3/1081	138/7206	7.70853684702e-07
ko04971	Gastric acid secretion	34/1081	98/7206	9.9718329135e-07
ko04730	Long-term depression	29/1081	78/7206	1.11389325577e-06
ko05164	Influenza A	6/1081	167/7206	2.68324173622e-06
ko05030	Cocaine addiction	27/1081	73/7206	2.92696963621e-06
ko04964	Proximal tubule bicarbonate reclamation	15/1081	29/7206	3.88403443689e-06
ko05322	Systemic lupus erythematosus	5/1081	151/7206	4.57528375556e-06
ko04514	Cell adhesion molecules (CAMs)	39/1081	130/7206	1.00360210064e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1081	74/7206	1.87299648101e-05
ko04925	Aldosterone synthesis and secretion	33/1081	105/7206	2.12575102374e-05
ko04976	Bile secretion	27/1081	80/7206	2.29824397563e-05
ko04621	NOD-like receptor signaling pathway	7/1081	157/7206	3.69983491797e-05
ko04924	Renin secretion	28/1081	86/7206	4.40972165479e-05
ko04360	Axon guidance	58/1081	233/7206	5.34771917904e-05
ko03013	RNA transport	8/1081	166/7206	5.83925475955e-05
ko04972	Pancreatic secretion	33/1081	111/7206	7.07034137203e-05
ko05414	Dilated cardiomyopathy	33/1081	112/7206	7.9557172037e-05
ko04610	Complement and coagulation cascades	1/1081	79/7206	8.56380932542e-05
ko04740	Olfactory transduction	26/1081	80/7206	9.36561306987e-05
ko04744	Phototransduction	15/1081	36/7206	9.89644777652e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1081	100/7206	0.000107259558507
ko04110	Cell cycle	7/1081	145/7206	0.000145278372527
ko04214	Apoptosis - fly	1/1081	72/7206	0.000182208985331
ko04745	Phototransduction - fly	15/1081	38/7206	0.000204763443502
ko05110	Vibrio cholerae infection	21/1081	63/7206	0.000241273337357
ko04978	Mineral absorption	15/1081	40/7206	0.000396634401209
ko05166	HTLV-I infection	24/1081	292/7206	0.0005624096588
ko03008	Ribosome biogenesis in eukaryotes	2/1081	79/7206	0.000650903115569
ko05140	Leishmaniasis	2/1081	75/7206	0.000909361415791
ko05169	Epstein-Barr virus infection	15/1081	206/7206	0.00099895236422
ko05162	Measles	6/1081	120/7206	0.00107799040928
ko04141	Protein processing in endoplasmic reticulum	13/1081	184/7206	0.00155505977598
ko04540	Gap junction	33/1081	128/7206	0.0015611335498
ko05161	Hepatitis B	12/1081	173/7206	0.00163834916719
ko00520	Amino sugar and nucleotide sugar metabolism	1/1081	55/7206	0.00210669353664
ko00480	Glutathione metabolism	1/1081	55/7206	0.00210669353664
ko04146	Peroxisome	4/1081	89/7206	0.00258876513341
ko04626	Plant-pathogen interaction	8/1081	18/7206	0.00268474857685
ko00240	Pyrimidine metabolism	6/1081	110/7206	0.00279115790725
ko05205	Proteoglycans in cancer	24/1081	271/7206	0.00306377441656
ko04612	Antigen processing and presentation	3/1081	77/7206	0.0033791359735
ko04064	NF-kappa B signaling pathway	5/1081	96/7206	0.00381470721841
ko04640	Hematopoietic cell lineage	2/1081	64/7206	0.00419973183846
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1081	182/7206	0.00425066664114
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1081	59/7206	0.00548670271712
ko04330	Notch signaling pathway	2/1081	62/7206	0.00627956949558
ko04371	Apelin signaling pathway	40/1081	177/7206	0.00730433535822
ko04014	Ras signaling pathway	58/1081	279/7206	0.00785264897639
ko03022	Basal transcription factors	1/1081	44/7206	0.0105152834872
ko00071	Fatty acid degradation	1/1081	45/7206	0.0105739044051
ko03420	Nucleotide excision repair	1/1081	46/7206	0.0109402876168
ko04142	Lysosome	12/1081	151/7206	0.011146575043
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1081	14/7206	0.0114545968206
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1081	92/7206	0.011566815368
ko05321	Inflammatory bowel disease (IBD)	2/1081	56/7206	0.0130197452391
ko04630	Jak-STAT signaling pathway	10/1081	132/7206	0.0134641781563
ko01524	Platinum drug resistance	4/1081	76/7206	0.0143253190462
ko04657	IL-17 signaling pathway	5/1081	87/7206	0.01445013589
ko05200	Pathways in cancer	56/1081	492/7206	0.0185241727916
ko00280	Valine, leucine and isoleucine degradation	2/1081	54/7206	0.0193808030201
ko04140	Autophagy - animal	14/1081	164/7206	0.0195042559714
ko04622	RIG-I-like receptor signaling pathway	3/1081	62/7206	0.0195860268145
ko00561	Glycerolipid metabolism	3/1081	63/7206	0.0197842899765
ko00310	Lysine degradation	4/1081	73/7206	0.0198630200166
ko04115	p53 signaling pathway	4/1081	74/7206	0.020328348989
ko05215	Prostate cancer	8/1081	111/7206	0.0216558754135
ko04922	Glucagon signaling pathway	29/1081	128/7206	0.0235601405414
ko04915	Estrogen signaling pathway	29/1081	131/7206	0.0258647526842
ko00380	Tryptophan metabolism	2/1081	50/7206	0.0268326577526
ko00680	Methane metabolism	10/1081	34/7206	0.0276351326957
ko04270	Vascular smooth muscle contraction	33/1081	154/7206	0.0296709123173
ko04750	Inflammatory mediator regulation of TRP channels	27/1081	122/7206	0.0299073763605
ko04658	Th1 and Th2 cell differentiation	7/1081	96/7206	0.0305386038723
ko04070	Phosphatidylinositol signaling system	25/1081	112/7206	0.0329896481651
ko04930	Type II diabetes mellitus	14/1081	54/7206	0.0334379936582
ko04672	Intestinal immune network for IgA production	1/1081	37/7206	0.0348832683656
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1081	165/7206	0.0352497854776
ko05010	Alzheimer's disease	41/1081	202/7206	0.0358939950511
ko03410	Base excision repair	1/1081	38/7206	0.0362092949959
ko04350	TGF-beta signaling pathway	8/1081	103/7206	0.0367235592183
ko04512	ECM-receptor interaction	19/1081	79/7206	0.0373713050363
ko05217	Basal cell carcinoma	4/1081	68/7206	0.0384369734988
ko04668	TNF signaling pathway	10/1081	120/7206	0.0386580203547
ko05219	Bladder cancer	2/1081	48/7206	0.0393772662367
ko04974	Protein digestion and absorption	22/1081	96/7206	0.0422270114962
ko05212	Pancreatic cancer	6/1081	83/7206	0.044319389116
ko05220	Chronic myeloid leukemia	6/1081	85/7206	0.0451597615911
ko00030	Pentose phosphate pathway	9/1081	32/7206	0.0464046734388
ko04620	Toll-like receptor signaling pathway	8/1081	100/7206	0.0480534084739