ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 15/112 134/7206 1.69535705657e-09 ko04668 TNF signaling pathway 13/112 120/7206 3.33405043382e-08 ko05164 Influenza A 13/112 167/7206 1.61820511492e-06 ko05161 Hepatitis B 13/112 173/7206 2.40947836856e-06 ko04931 Insulin resistance 11/112 137/7206 8.00979972315e-06 ko04620 Toll-like receptor signaling pathway 9/112 100/7206 2.23818307654e-05 ko05168 Herpes simplex infection 12/112 182/7206 2.28990605566e-05 ko04621 NOD-like receptor signaling pathway 11/112 157/7206 2.91800522116e-05 ko05142 Chagas disease (American trypanosomiasis) 10/112 130/7206 3.07322048073e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 12/112 191/7206 3.70085926245e-05 ko04920 Adipocytokine signaling pathway 8/112 89/7206 6.57572301006e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/112 182/7206 0.000112648820652 ko05160 Hepatitis C 10/112 153/7206 0.00012279664892 ko04630 Jak-STAT signaling pathway 9/112 132/7206 0.000197363053596 ko04657 IL-17 signaling pathway 7/112 87/7206 0.000381076563164 ko04623 Cytosolic DNA-sensing pathway 5/112 41/7206 0.000397821450642 ko04210 Apoptosis 10/112 180/7206 0.000460178529102 ko05162 Measles 8/112 120/7206 0.000525261250656 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/112 92/7206 0.000536087452484 ko05166 HTLV-I infection 13/112 292/7206 0.00056060426882 ko04660 T cell receptor signaling pathway 8/112 124/7206 0.000653758368785 ko01522 Endocrine resistance 8/112 124/7206 0.000653758368785 ko04658 Th1 and Th2 cell differentiation 7/112 96/7206 0.000693182967779 ko04064 NF-kappa B signaling pathway 7/112 96/7206 0.000693182967779 ko05145 Toxoplasmosis 8/112 126/7206 0.000726921746228 ko04060 Cytokine-cytokine receptor interaction 10/112 191/7206 0.000733032786209 ko05132 Salmonella infection 7/112 98/7206 0.00078435906517 ko05140 Leishmaniasis 6/112 75/7206 0.00103860263927 ko04137 Mitophagy - animal 6/112 82/7206 0.0016543480189 ko05321 Inflammatory bowel disease (IBD) 5/112 56/7206 0.00168567932032 ko04662 B cell receptor signaling pathway 6/112 88/7206 0.0023750569566 ko04672 Intestinal immune network for IgA production 4/112 37/7206 0.0024600619201 ko05323 Rheumatoid arthritis 6/112 89/7206 0.00251508142578 ko04622 RIG-I-like receptor signaling pathway 5/112 62/7206 0.00265281915774 ko05134 Legionellosis 5/112 74/7206 0.0057014650908 ko04115 p53 signaling pathway 5/112 74/7206 0.0057014650908 ko04659 Th17 cell differentiation 6/112 106/7206 0.00597121191647 ko04624 Toll and Imd signaling pathway 4/112 49/7206 0.00684408174564 ko05152 Tuberculosis 8/112 187/7206 0.00845583071037 ko05131 Shigellosis 5/112 82/7206 0.00875893216067 ko04930 Type II diabetes mellitus 4/112 54/7206 0.00962915142004 ko05210 Colorectal cancer 5/112 86/7206 0.0106480732354 ko04917 Prolactin signaling pathway 5/112 87/7206 0.0111607001431 ko05133 Pertussis 5/112 87/7206 0.0111607001431 ko04211 Longevity regulating pathway 6/112 123/7206 0.0120398521785 ko04080 Neuroactive ligand-receptor interaction 1/112 423/7206 0.0144233103598 ko04068 FoxO signaling pathway 7/112 167/7206 0.0149913582318 ko04915 Estrogen signaling pathway 6/112 131/7206 0.0160353929354 ko04933 AGE-RAGE signaling pathway in diabetic complications 6/112 135/7206 0.0183429543421 ko05224 Breast cancer 7/112 174/7206 0.0183968838178 ko04218 Cellular senescence 7/112 177/7206 0.0200113778161 ko04217 Necroptosis 7/112 178/7206 0.0205709513457 ko00051 Fructose and mannose metabolism 3/112 42/7206 0.0270501236616 ko04010 MAPK signaling pathway 10/112 321/7206 0.0329938397794 ko00120 Primary bile acid biosynthesis 2/112 20/7206 0.0379141566497 ko04722 Neurotrophin signaling pathway 6/112 160/7206 0.038026581537 ko04152 AMPK signaling pathway 6/112 161/7206 0.0390165142693 ko05169 Epstein-Barr virus infection 7/112 206/7206 0.0409725717023 ko05220 Chronic myeloid leukemia 4/112 85/7206 0.0428715975398 ko04213 Longevity regulating pathway - multiple species 4/112 86/7206 0.0444434767738 ko05222 Small cell lung cancer 4/112 89/7206 0.0493516536291