ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1098	423/7206	2.52532092e-45
ko04724	Glutamatergic synapse	84/1098	152/7206	7.34877899766e-31
ko05033	Nicotine addiction	47/1098	56/7206	3.16894397103e-30
ko05032	Morphine addiction	66/1098	110/7206	2.7196433874e-27
ko04727	GABAergic synapse	62/1098	110/7206	1.21311809621e-23
ko04713	Circadian entrainment	70/1098	136/7206	2.07085807715e-23
ko04728	Dopaminergic synapse	83/1098	185/7206	1.90014833224e-22
ko04721	Synaptic vesicle cycle	49/1098	80/7206	4.2379984695e-21
ko04725	Cholinergic synapse	73/1098	160/7206	2.20626873676e-20
ko04723	Retrograde endocannabinoid signaling	76/1098	175/7206	1.3471515777e-19
ko04024	cAMP signaling pathway	100/1098	279/7206	3.78136667345e-18
ko04742	Taste transduction	36/1098	61/7206	4.22146291132e-15
ko04020	Calcium signaling pathway	90/1098	265/7206	9.54179451926e-15
ko04921	Oxytocin signaling pathway	76/1098	209/7206	2.03995945398e-14
ko04261	Adrenergic signaling in cardiomyocytes	74/1098	205/7206	1.13000594218e-13
ko04911	Insulin secretion	50/1098	117/7206	5.77250661264e-13
ko04726	Serotonergic synapse	53/1098	137/7206	1.28530564854e-11
ko04744	Phototransduction	23/1098	36/7206	4.09348451063e-11
ko05031	Amphetamine addiction	40/1098	91/7206	4.29600927071e-11
ko04720	Long-term potentiation	41/1098	99/7206	2.37179894653e-10
ko03040	Spliceosome	1/1098	145/7206	1.35214465149e-09
ko04970	Salivary secretion	37/1098	95/7206	1.33827298769e-08
ko04360	Axon guidance	68/1098	233/7206	4.22068361178e-08
ko05203	Viral carcinogenesis	14/1098	277/7206	8.832747829e-08
ko04925	Aldosterone synthesis and secretion	38/1098	105/7206	1.11924559514e-07
ko04740	Olfactory transduction	31/1098	80/7206	2.30713353067e-07
ko05168	Herpes simplex infection	6/1098	182/7206	2.94582257926e-07
ko04060	Cytokine-cytokine receptor interaction	7/1098	191/7206	3.46346283779e-07
ko04022	cGMP-PKG signaling pathway	62/1098	216/7206	3.55954818939e-07
ko04971	Gastric acid secretion	35/1098	98/7206	4.87538195783e-07
ko05030	Cocaine addiction	28/1098	73/7206	1.12808553269e-06
ko05164	Influenza A	6/1098	167/7206	1.79916692233e-06
ko05322	Systemic lupus erythematosus	5/1098	151/7206	3.03858971726e-06
ko04010	MAPK signaling pathway	80/1098	321/7206	3.41593450764e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1098	74/7206	5.36014238124e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1098	79/7206	8.8672026013e-06
ko03013	RNA transport	7/1098	166/7206	8.93271535478e-06
ko04924	Renin secretion	29/1098	86/7206	2.46321742467e-05
ko04621	NOD-like receptor signaling pathway	7/1098	157/7206	2.55115819405e-05
ko04966	Collecting duct acid secretion	13/1098	26/7206	3.31806642878e-05
ko05414	Dilated cardiomyopathy	34/1098	112/7206	4.71687183051e-05
ko04070	Phosphatidylinositol signaling system	34/1098	112/7206	4.71687183051e-05
ko04120	Ubiquitin mediated proteolysis	6/1098	138/7206	6.58714648833e-05
ko04260	Cardiac muscle contraction	30/1098	98/7206	9.74503960895e-05
ko04141	Protein processing in endoplasmic reticulum	11/1098	184/7206	0.000154974119589
ko04745	Phototransduction - fly	15/1098	38/7206	0.000244502031917
ko04514	Cell adhesion molecules (CAMs)	36/1098	130/7206	0.000283427911801
ko04014	Ras signaling pathway	65/1098	279/7206	0.000326569549185
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1098	14/7206	0.000360250581245
ko03008	Ribosome biogenesis in eukaryotes	2/1098	79/7206	0.000409315645834
ko04972	Pancreatic secretion	31/1098	111/7206	0.000478787066865
ko05205	Proteoglycans in cancer	22/1098	271/7206	0.000526425671935
ko04915	Estrogen signaling pathway	35/1098	131/7206	0.00054093420536
ko04072	Phospholipase D signaling pathway	48/1098	197/7206	0.0005992500605
ko04730	Long-term depression	24/1098	78/7206	0.00064888582799
ko04540	Gap junction	34/1098	128/7206	0.000738051899971
ko05169	Epstein-Barr virus infection	15/1098	206/7206	0.000749351496301
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1098	59/7206	0.000870578322015
ko04064	NF-kappa B signaling pathway	4/1098	96/7206	0.000887404730167
ko05140	Leishmaniasis	2/1098	75/7206	0.000938608914914
ko05110	Vibrio cholerae infection	20/1098	63/7206	0.00109156448973
ko00240	Pyrimidine metabolism	6/1098	110/7206	0.00198519526758
ko05162	Measles	7/1098	120/7206	0.00198902334353
ko00480	Glutathione metabolism	1/1098	55/7206	0.00208644318342
ko04923	Regulation of lipolysis in adipocytes	22/1098	77/7206	0.00225895096256
ko04976	Bile secretion	23/1098	80/7206	0.0024450842307
ko04146	Peroxisome	4/1098	89/7206	0.002596172406
ko05161	Hepatitis B	13/1098	173/7206	0.00262549569744
ko04371	Apelin signaling pathway	42/1098	177/7206	0.00280728423677
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1098	100/7206	0.00282546310148
ko04626	Plant-pathogen interaction	8/1098	18/7206	0.00297162693815
ko00590	Arachidonic acid metabolism	1/1098	52/7206	0.00311578372065
ko04110	Cell cycle	10/1098	145/7206	0.00327270643448
ko04612	Antigen processing and presentation	3/1098	77/7206	0.00346969945742
ko04640	Hematopoietic cell lineage	2/1098	64/7206	0.00430419686176
ko04214	Apoptosis - fly	3/1098	72/7206	0.00474680580034
ko00330	Arginine and proline metabolism	2/1098	61/7206	0.00619889203907
ko03420	Nucleotide excision repair	1/1098	46/7206	0.00698111892748
ko04750	Inflammatory mediator regulation of TRP channels	30/1098	122/7206	0.00704426750886
ko00260	Glycine, serine and threonine metabolism	1/1098	48/7206	0.00726601651523
ko04964	Proximal tubule bicarbonate reclamation	10/1098	29/7206	0.00816480956675
ko03022	Basal transcription factors	1/1098	44/7206	0.0104213516986
ko05144	Malaria	1/1098	45/7206	0.0106938216496
ko00071	Fatty acid degradation	1/1098	45/7206	0.0106938216496
ko05321	Inflammatory bowel disease (IBD)	2/1098	56/7206	0.0133558095189
ko03018	RNA degradation	5/1098	84/7206	0.0138842109774
ko04210	Apoptosis	16/1098	180/7206	0.0152808028706
ko00140	Steroid hormone biosynthesis	1/1098	41/7206	0.0154978865007
ko00562	Inositol phosphate metabolism	22/1098	89/7206	0.0169946216279
ko04622	RIG-I-like receptor signaling pathway	3/1098	62/7206	0.0196124881466
ko00310	Lysine degradation	4/1098	73/7206	0.0202569976573
ko04510	Focal adhesion	24/1098	240/7206	0.0219697868016
ko04270	Vascular smooth muscle contraction	34/1098	154/7206	0.022744447557
ko03410	Base excision repair	1/1098	38/7206	0.0230526672388
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1098	40/7206	0.0241089594363
ko05166	HTLV-I infection	31/1098	292/7206	0.0245507571424
ko05219	Bladder cancer	2/1098	48/7206	0.0263718274548
ko04630	Jak-STAT signaling pathway	11/1098	132/7206	0.0269086129843
ko00380	Tryptophan metabolism	2/1098	50/7206	0.0272244186277
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1098	92/7206	0.0273600035185
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1098	182/7206	0.0275282831038
ko04658	Th1 and Th2 cell differentiation	7/1098	96/7206	0.0307071430142
ko04657	IL-17 signaling pathway	6/1098	87/7206	0.0339037372283
ko05133	Pertussis	6/1098	87/7206	0.0339037372283
ko04217	Necroptosis	17/1098	178/7206	0.034050931067
ko00982	Drug metabolism - cytochrome P450	1/1098	37/7206	0.0352991773516
ko01524	Platinum drug resistance	5/1098	76/7206	0.0355892191468
ko04350	TGF-beta signaling pathway	8/1098	103/7206	0.0369877936288
ko00620	Pyruvate metabolism	2/1098	46/7206	0.0379855728551
ko04670	Leukocyte transendothelial migration	14/1098	151/7206	0.039038878707
ko04668	TNF signaling pathway	10/1098	120/7206	0.039145229522
ko04912	GnRH signaling pathway	27/1098	122/7206	0.0410871029381
ko04114	Oocyte meiosis	30/1098	139/7206	0.042186059708
ko05131	Shigellosis	6/1098	82/7206	0.0440543327308
ko04722	Neurotrophin signaling pathway	34/1098	160/7206	0.0442425044079
ko05145	Toxoplasmosis	11/1098	126/7206	0.0443452060473
ko04922	Glucagon signaling pathway	28/1098	128/7206	0.0458904567456
ko04140	Autophagy - animal	16/1098	164/7206	0.0478069929545
ko04620	Toll-like receptor signaling pathway	8/1098	100/7206	0.0483431109255
ko04115	p53 signaling pathway	5/1098	74/7206	0.0488892754494