ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1005	423/7206	1.89039417015e-48
ko05033	Nicotine addiction	47/1005	56/7206	5.143638638e-32
ko04724	Glutamatergic synapse	78/1005	152/7206	1.68270214011e-28
ko05032	Morphine addiction	56/1005	110/7206	1.60825958247e-20
ko04727	GABAergic synapse	54/1005	110/7206	6.81420501742e-19
ko04713	Circadian entrainment	60/1005	136/7206	5.57549146934e-18
ko04728	Dopaminergic synapse	72/1005	185/7206	1.21336071776e-17
ko04721	Synaptic vesicle cycle	43/1005	80/7206	3.48911477528e-17
ko04024	cAMP signaling pathway	89/1005	279/7206	3.91194505199e-15
ko04725	Cholinergic synapse	61/1005	160/7206	1.25398176765e-14
ko04742	Taste transduction	34/1005	61/7206	1.7602579867e-14
ko04723	Retrograde endocannabinoid signaling	63/1005	175/7206	1.03428301504e-13
ko04726	Serotonergic synapse	50/1005	137/7206	2.17719930755e-11
ko04911	Insulin secretion	45/1005	117/7206	2.85916150374e-11
ko05030	Cocaine addiction	33/1005	73/7206	8.312794224e-11
ko05031	Amphetamine addiction	37/1005	91/7206	2.60766219143e-10
ko04020	Calcium signaling pathway	74/1005	265/7206	1.16960030396e-09
ko03040	Spliceosome	1/1005	145/7206	1.4906639379e-08
ko04360	Axon guidance	64/1005	233/7206	3.85828392622e-08
ko05203	Viral carcinogenesis	11/1005	277/7206	4.16522652519e-08
ko04740	Olfactory transduction	30/1005	80/7206	1.15219861052e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1005	74/7206	2.44665922139e-07
ko05168	Herpes simplex infection	5/1005	182/7206	3.69345119101e-07
ko05164	Influenza A	4/1005	167/7206	3.96498898717e-07
ko04921	Oxytocin signaling pathway	56/1005	209/7206	7.17607574049e-07
ko04261	Adrenergic signaling in cardiomyocytes	55/1005	205/7206	9.50081451404e-07
ko04720	Long-term potentiation	33/1005	99/7206	9.81867394302e-07
ko04744	Phototransduction	17/1005	36/7206	1.5718700382e-06
ko04120	Ubiquitin mediated proteolysis	3/1005	138/7206	2.80301101568e-06
ko04060	Cytokine-cytokine receptor interaction	7/1005	191/7206	3.593228037e-06
ko03013	RNA transport	5/1005	166/7206	3.64070109059e-06
ko04010	MAPK signaling pathway	74/1005	321/7206	6.99703683051e-06
ko05169	Epstein-Barr virus infection	9/1005	206/7206	8.67494359679e-06
ko05162	Measles	3/1005	120/7206	2.85078777131e-05
ko04970	Salivary secretion	29/1005	95/7206	3.14252254262e-05
ko04621	NOD-like receptor signaling pathway	6/1005	157/7206	3.63688034583e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1005	79/7206	4.74136719464e-05
ko04950	Maturity onset diabetes of the young	13/1005	29/7206	5.416157535e-05
ko05322	Systemic lupus erythematosus	6/1005	151/7206	7.32046924962e-05
ko04141	Protein processing in endoplasmic reticulum	9/1005	184/7206	8.83624537803e-05
ko04514	Cell adhesion molecules (CAMs)	35/1005	130/7206	9.19330308593e-05
ko04730	Long-term depression	24/1005	78/7206	0.000103362944938
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/1005	182/7206	0.000123434698657
ko04260	Cardiac muscle contraction	28/1005	98/7206	0.000164543541162
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1005	14/7206	0.000191455794513
ko03008	Ribosome biogenesis in eukaryotes	1/1005	79/7206	0.000211175543918
ko04924	Renin secretion	25/1005	86/7206	0.000224283917914
ko04214	Apoptosis - fly	1/1005	72/7206	0.000450183816413
ko03018	RNA degradation	2/1005	84/7206	0.000671213699885
ko04022	cGMP-PKG signaling pathway	48/1005	216/7206	0.000902446258473
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1005	59/7206	0.000917933323573
ko04971	Gastric acid secretion	26/1005	98/7206	0.000988135749586
ko01200	Carbon metabolism	6/1005	128/7206	0.00111832230432
ko04964	Proximal tubule bicarbonate reclamation	11/1005	29/7206	0.00114505034028
ko04925	Aldosterone synthesis and secretion	27/1005	105/7206	0.00148852959128
ko04610	Complement and coagulation cascades	2/1005	79/7206	0.00149898491374
ko04110	Cell cycle	8/1005	145/7206	0.00153761262073
ko04974	Protein digestion and absorption	25/1005	96/7206	0.00154268239708
ko04966	Collecting duct acid secretion	10/1005	26/7206	0.00169303234829
ko04146	Peroxisome	3/1005	89/7206	0.00174375264423
ko04540	Gap junction	31/1005	128/7206	0.00175079825841
ko00240	Pyrimidine metabolism	5/1005	110/7206	0.00206590674293
ko05140	Leishmaniasis	2/1005	75/7206	0.00209779169944
ko04978	Mineral absorption	13/1005	40/7206	0.00218411498712
ko04064	NF-kappa B signaling pathway	4/1005	96/7206	0.00273588842793
ko05321	Inflammatory bowel disease (IBD)	1/1005	56/7206	0.00333487753899
ko05034	Alcoholism	49/1005	238/7206	0.00413903850918
ko04014	Ras signaling pathway	56/1005	279/7206	0.00458980027031
ko04915	Estrogen signaling pathway	30/1005	131/7206	0.00481344150418
ko00280	Valine, leucine and isoleucine degradation	1/1005	54/7206	0.00497213136562
ko04138	Autophagy - yeast	3/1005	81/7206	0.00526997102524
ko05205	Proteoglycans in cancer	23/1005	271/7206	0.00710954501065
ko00590	Arachidonic acid metabolism	1/1005	52/7206	0.00756975663856
ko04972	Pancreatic secretion	26/1005	111/7206	0.00793701430126
ko05414	Dilated cardiomyopathy	26/1005	112/7206	0.00824518723603
ko04976	Bile secretion	20/1005	80/7206	0.00833279362555
ko04640	Hematopoietic cell lineage	2/1005	64/7206	0.00966405879871
ko04512	ECM-receptor interaction	19/1005	79/7206	0.0136697945744
ko05131	Shigellosis	4/1005	82/7206	0.0149694820725
ko04217	Necroptosis	14/1005	178/7206	0.0156116631428
ko05144	Malaria	1/1005	45/7206	0.0162686447943
ko00071	Fatty acid degradation	1/1005	45/7206	0.0162686447943
ko03420	Nucleotide excision repair	1/1005	46/7206	0.0165994711172
ko04612	Antigen processing and presentation	4/1005	77/7206	0.0204284839694
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1005	26/7206	0.0213482956652
ko04140	Autophagy - animal	13/1005	164/7206	0.0222478043064
ko00565	Ether lipid metabolism	1/1005	42/7206	0.0240709557543
ko03022	Basal transcription factors	1/1005	44/7206	0.0255257098851
ko05418	Fluid shear stress and atherosclerosis	14/1005	173/7206	0.0255505091469
ko05161	Hepatitis B	14/1005	173/7206	0.0255505091469
ko05145	Toxoplasmosis	9/1005	126/7206	0.0264541183429
ko04015	Rap1 signaling pathway	52/1005	278/7206	0.026788222895
ko04011	MAPK signaling pathway - yeast	2/1005	53/7206	0.0274739302732
ko04657	IL-17 signaling pathway	5/1005	87/7206	0.0276420154601
ko05133	Pertussis	5/1005	87/7206	0.0276420154601
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1005	100/7206	0.0278499799161
ko04115	p53 signaling pathway	4/1005	74/7206	0.0281765670442
ko00561	Glycerolipid metabolism	3/1005	63/7206	0.0285456512366
ko00600	Sphingolipid metabolism	3/1005	63/7206	0.0285456512366
ko00480	Glutathione metabolism	2/1005	55/7206	0.0287425554642
ko04630	Jak-STAT signaling pathway	10/1005	132/7206	0.0307850430755
ko04142	Lysosome	12/1005	151/7206	0.031881115289
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1005	40/7206	0.0361689849203
ko00310	Lysine degradation	4/1005	73/7206	0.0394541603268
ko01212	Fatty acid metabolism	3/1005	60/7206	0.0398800322358
ko00330	Arginine and proline metabolism	3/1005	61/7206	0.0399263371549
ko04622	RIG-I-like receptor signaling pathway	3/1005	62/7206	0.0405023429595
ko04620	Toll-like receptor signaling pathway	7/1005	100/7206	0.0416063560598
ko04668	TNF signaling pathway	9/1005	120/7206	0.0448873621187
ko04930	Type II diabetes mellitus	13/1005	54/7206	0.0453800521148
ko05166	HTLV-I infection	29/1005	292/7206	0.0468319538002