ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1143	423/7206	1.073909497e-46
ko04724	Glutamatergic synapse	88/1143	152/7206	4.93779424855e-33
ko05033	Nicotine addiction	46/1143	56/7206	5.31981303859e-28
ko05032	Morphine addiction	66/1143	110/7206	3.0307803737e-26
ko04713	Circadian entrainment	73/1143	136/7206	9.62097412828e-25
ko04727	GABAergic synapse	64/1143	110/7206	1.97686444088e-24
ko04721	Synaptic vesicle cycle	51/1143	80/7206	2.99563116548e-22
ko04725	Cholinergic synapse	76/1143	160/7206	2.04710495342e-21
ko04728	Dopaminergic synapse	83/1143	185/7206	2.86990636658e-21
ko04723	Retrograde endocannabinoid signaling	76/1143	175/7206	1.53942272908e-18
ko04024	cAMP signaling pathway	100/1143	279/7206	7.64801476067e-17
ko04726	Serotonergic synapse	61/1143	137/7206	9.99887746806e-16
ko04020	Calcium signaling pathway	94/1143	265/7206	1.39134739356e-15
ko04742	Taste transduction	36/1143	61/7206	1.53420802808e-14
ko04921	Oxytocin signaling pathway	78/1143	209/7206	2.13154597584e-14
ko04911	Insulin secretion	53/1143	117/7206	3.32182344247e-14
ko04744	Phototransduction	24/1143	36/7206	9.40699918234e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1143	205/7206	1.93168724154e-11
ko04720	Long-term potentiation	43/1143	99/7206	5.02368077617e-11
ko05031	Amphetamine addiction	40/1143	91/7206	1.53011994242e-10
ko03040	Spliceosome	1/1143	145/7206	5.13595164899e-10
ko04970	Salivary secretion	40/1143	95/7206	7.44940389677e-10
ko04925	Aldosterone synthesis and secretion	39/1143	105/7206	9.05210896588e-08
ko04971	Gastric acid secretion	36/1143	98/7206	3.82288708864e-07
ko04360	Axon guidance	67/1143	233/7206	3.82991508977e-07
ko04070	Phosphatidylinositol signaling system	39/1143	112/7206	6.39055586506e-07
ko04966	Collecting duct acid secretion	15/1143	26/7206	1.26482959477e-06
ko05203	Viral carcinogenesis	18/1143	277/7206	2.18161447903e-06
ko04621	NOD-like receptor signaling pathway	6/1143	157/7206	2.39775821894e-06
ko05030	Cocaine addiction	28/1143	73/7206	2.56753699318e-06
ko04022	cGMP-PKG signaling pathway	61/1143	216/7206	2.69586350954e-06
ko04740	Olfactory transduction	30/1143	80/7206	2.89084088246e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1143	74/7206	3.5149531927e-06
ko03013	RNA transport	7/1143	166/7206	4.23379170383e-06
ko05322	Systemic lupus erythematosus	6/1143	151/7206	7.54031285852e-06
ko04060	Cytokine-cytokine receptor interaction	10/1143	191/7206	7.60517013111e-06
ko04514	Cell adhesion molecules (CAMs)	41/1143	130/7206	7.96564770807e-06
ko04010	MAPK signaling pathway	81/1143	321/7206	1.01554496649e-05
ko04540	Gap junction	40/1143	128/7206	1.24173420725e-05
ko05168	Herpes simplex infection	10/1143	182/7206	2.07542088582e-05
ko04072	Phospholipase D signaling pathway	54/1143	197/7206	2.69810457462e-05
ko04972	Pancreatic secretion	35/1143	111/7206	3.31915852262e-05
ko04924	Renin secretion	29/1143	86/7206	3.71357700485e-05
ko05164	Influenza A	9/1143	167/7206	3.89413638368e-05
ko04730	Long-term depression	27/1143	78/7206	5.5376925351e-05
ko04141	Protein processing in endoplasmic reticulum	11/1143	184/7206	5.62094933272e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1143	79/7206	6.24433137013e-05
ko05110	Vibrio cholerae infection	23/1143	63/7206	6.82452445537e-05
ko04745	Phototransduction - fly	16/1143	38/7206	9.97089817163e-05
ko04064	NF-kappa B signaling pathway	3/1143	96/7206	0.000110702311447
ko05414	Dilated cardiomyopathy	34/1143	112/7206	0.000114271369224
ko04120	Ubiquitin mediated proteolysis	7/1143	138/7206	0.000136230262966
ko04915	Estrogen signaling pathway	38/1143	131/7206	0.000141585051979
ko04014	Ras signaling pathway	68/1143	279/7206	0.000158048581813
ko04976	Bile secretion	26/1143	80/7206	0.000174570415809
ko04110	Cell cycle	8/1143	145/7206	0.000199395516139
ko04964	Proximal tubule bicarbonate reclamation	13/1143	29/7206	0.000210355903492
ko04610	Complement and coagulation cascades	2/1143	79/7206	0.000266926616061
ko03008	Ribosome biogenesis in eukaryotes	2/1143	79/7206	0.000266926616061
ko04750	Inflammatory mediator regulation of TRP channels	35/1143	122/7206	0.00037630174808
ko05140	Leishmaniasis	2/1143	75/7206	0.000390811592396
ko04612	Antigen processing and presentation	2/1143	77/7206	0.000405736685134
ko04260	Cardiac muscle contraction	29/1143	98/7206	0.000661591818518
ko04626	Plant-pathogen interaction	9/1143	18/7206	0.00076726051431
ko04371	Apelin signaling pathway	44/1143	177/7206	0.00166461795364
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1143	59/7206	0.00177924060399
ko04146	Peroxisome	4/1143	89/7206	0.00181603927533
ko05169	Epstein-Barr virus infection	17/1143	206/7206	0.00181987321607
ko04923	Regulation of lipolysis in adipocytes	23/1143	77/7206	0.0023773050658
ko05205	Proteoglycans in cancer	26/1143	271/7206	0.00293582457667
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1143	14/7206	0.0030428417516
ko05161	Hepatitis B	14/1143	173/7206	0.00307079629386
ko00240	Pyrimidine metabolism	7/1143	110/7206	0.00362143229921
ko00330	Arginine and proline metabolism	2/1143	61/7206	0.00407765773831
ko04710	Circadian rhythm	14/1143	43/7206	0.00557689378668
ko00071	Fatty acid degradation	1/1143	45/7206	0.00679667648678
ko03420	Nucleotide excision repair	1/1143	46/7206	0.00701613576181
ko00562	Inositol phosphate metabolism	24/1143	89/7206	0.00775671277112
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1143	100/7206	0.00830539549849
ko00480	Glutathione metabolism	2/1143	55/7206	0.00852255575421
ko05321	Inflammatory bowel disease (IBD)	2/1143	56/7206	0.00878072465346
ko04217	Necroptosis	16/1143	178/7206	0.00916302287022
ko04640	Hematopoietic cell lineage	3/1143	64/7206	0.00941739771118
ko04115	p53 signaling pathway	4/1143	74/7206	0.00982476868652
ko00310	Lysine degradation	4/1143	73/7206	0.00983225024107
ko04711	Circadian rhythm - fly	6/1143	13/7206	0.00987170503812
ko03022	Basal transcription factors	1/1143	44/7206	0.0108512610114
ko05162	Measles	9/1143	120/7206	0.0110179000076
ko04510	Focal adhesion	24/1143	240/7206	0.011517510456
ko04912	GnRH signaling pathway	30/1143	122/7206	0.0118239179171
ko00590	Arachidonic acid metabolism	2/1143	52/7206	0.012342185322
ko04930	Type II diabetes mellitus	16/1143	54/7206	0.013168021992
ko05145	Toxoplasmosis	10/1143	126/7206	0.0132016392855
ko04330	Notch signaling pathway	3/1143	62/7206	0.0134715873538
ko04622	RIG-I-like receptor signaling pathway	3/1143	62/7206	0.0134715873538
ko05131	Shigellosis	5/1143	82/7206	0.0138670172881
ko04214	Apoptosis - fly	4/1143	72/7206	0.0138957868371
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1143	40/7206	0.0152476055476
ko00140	Steroid hormone biosynthesis	1/1143	41/7206	0.015818062558
ko04658	Th1 and Th2 cell differentiation	7/1143	96/7206	0.0166508692669
ko04213	Longevity regulating pathway - multiple species	22/1143	86/7206	0.0172506173401
ko04657	IL-17 signaling pathway	6/1143	87/7206	0.0177293546727
ko05133	Pertussis	6/1143	87/7206	0.0177293546727
ko03320	PPAR signaling pathway	4/1143	69/7206	0.0192614738523
ko04916	Melanogenesis	33/1143	142/7206	0.019815786915
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1143	92/7206	0.0209570366998
ko00982	Drug metabolism - cytochrome P450	1/1143	37/7206	0.0225957822502
ko05231	Choline metabolism in cancer	31/1143	134/7206	0.0234115990731
ko04062	Chemokine signaling pathway	44/1143	201/7206	0.0237457467903
ko03018	RNA degradation	6/1143	84/7206	0.0239952261857
ko00260	Glycine, serine and threonine metabolism	2/1143	48/7206	0.026643883934
ko04922	Glucagon signaling pathway	30/1143	128/7206	0.0269745844783
ko05166	HTLV-I infection	33/1143	292/7206	0.0273216112933
ko04722	Neurotrophin signaling pathway	36/1143	160/7206	0.0278305433601
ko04210	Apoptosis	18/1143	180/7206	0.0295357902776
ko04973	Carbohydrate digestion and absorption	12/1143	42/7206	0.0324941992005
ko04975	Fat digestion and absorption	1/1143	35/7206	0.033995614822
ko00500	Starch and sucrose metabolism	1/1143	35/7206	0.033995614822
ko04015	Rap1 signaling pathway	57/1143	278/7206	0.0360031890215
ko05222	Small cell lung cancer	7/1143	89/7206	0.0397681005773
ko04114	Oocyte meiosis	31/1143	139/7206	0.0452912468061