ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 24/401 80/7206 3.57820265471e-12 ko04728 Dopaminergic synapse 37/401 185/7206 4.61623325533e-12 ko04727 GABAergic synapse 27/401 110/7206 2.9163933833e-11 ko04724 Glutamatergic synapse 32/401 152/7206 3.35110432886e-11 ko05033 Nicotine addiction 19/401 56/7206 6.044404421e-11 ko05032 Morphine addiction 24/401 110/7206 4.92133479307e-09 ko04723 Retrograde endocannabinoid signaling 29/401 175/7206 8.94411633833e-08 ko04725 Cholinergic synapse 27/401 160/7206 1.72084419799e-07 ko04713 Circadian entrainment 23/401 136/7206 1.38276479459e-06 ko04514 Cell adhesion molecules (CAMs) 22/401 130/7206 2.32505915896e-06 ko04911 Insulin secretion 20/401 117/7206 5.74310343148e-06 ko04360 Axon guidance 30/401 233/7206 1.39107712458e-05 ko04726 Serotonergic synapse 21/401 137/7206 1.93778935476e-05 ko04080 Neuroactive ligand-receptor interaction 45/401 423/7206 2.39186491852e-05 ko04261 Adrenergic signaling in cardiomyocytes 27/401 205/7206 2.96439112308e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 14/401 74/7206 4.61355897833e-05 ko04964 Proximal tubule bicarbonate reclamation 8/401 29/7206 0.000130702498853 ko04970 Salivary secretion 15/401 95/7206 0.000213956641811 ko05031 Amphetamine addiction 14/401 91/7206 0.000454709613412 ko04150 mTOR signaling pathway 1/401 184/7206 0.000486828582121 ko05030 Cocaine addiction 12/401 73/7206 0.000623708110442 ko04611 Platelet activation 1/401 163/7206 0.00153391241222 ko05164 Influenza A 1/401 167/7206 0.00161439700111 ko04060 Cytokine-cytokine receptor interaction 2/401 191/7206 0.00209152744088 ko04022 cGMP-PKG signaling pathway 23/401 216/7206 0.00231902711395 ko04966 Collecting duct acid secretion 6/401 26/7206 0.00254117049406 ko05322 Systemic lupus erythematosus 1/401 151/7206 0.00334103019073 ko04391 Hippo signaling pathway - fly 12/401 90/7206 0.00395780601738 ko05205 Proteoglycans in cancer 5/401 271/7206 0.00407758922467 ko05168 Herpes simplex infection 2/401 182/7206 0.00450683990198 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/401 182/7206 0.00450683990198 ko04972 Pancreatic secretion 14/401 111/7206 0.00490037818734 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/401 59/7206 0.00492756433856 ko03040 Spliceosome 1/401 145/7206 0.00495302719055 ko04120 Ubiquitin mediated proteolysis 1/401 138/7206 0.00722065833594 ko05203 Viral carcinogenesis 6/401 277/7206 0.00734622222801 ko04924 Renin secretion 11/401 86/7206 0.00779075784983 ko04010 MAPK signaling pathway 29/401 321/7206 0.00857607119055 ko04140 Autophagy - animal 2/401 164/7206 0.00872742642943 ko03013 RNA transport 2/401 166/7206 0.00891051593142 ko04024 cAMP signaling pathway 26/401 279/7206 0.0104821368209 ko04720 Long-term potentiation 12/401 99/7206 0.0118408349851 ko05166 HTLV-I infection 7/401 292/7206 0.012652509882 ko04211 Longevity regulating pathway 1/401 123/7206 0.0150273573876 ko04745 Phototransduction - fly 6/401 38/7206 0.0173657855968 ko04950 Maturity onset diabetes of the young 5/401 29/7206 0.0204414736926 ko04974 Protein digestion and absorption 11/401 96/7206 0.0210829372555 ko04145 Phagosome 16/401 162/7206 0.0227933126154 ko00230 Purine metabolism 4/401 194/7206 0.0255717284073 ko04940 Type I diabetes mellitus 5/401 32/7206 0.0302681647027 ko04914 Progesterone-mediated oocyte maturation 1/401 104/7206 0.0303507541004 ko00240 Pyrimidine metabolism 1/401 110/7206 0.0320608705038 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/401 92/7206 0.0361053420645 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/401 14/7206 0.0393671785276 ko04151 PI3K-Akt signaling pathway 31/401 390/7206 0.0404542597527 ko04512 ECM-receptor interaction 9/401 79/7206 0.0411247349741 ko04976 Bile secretion 9/401 80/7206 0.0427823138625 ko05146 Amoebiasis 1/401 99/7206 0.0440841885886 ko02024 Quorum sensing 3/401 15/7206 0.0472351049045 ko04744 Phototransduction 5/401 36/7206 0.0473460480188 ko05012 Parkinson's disease 3/401 155/7206 0.0488502044154 ko04621 NOD-like receptor signaling pathway 3/401 157/7206 0.0496908850007