ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 63/1086 152/7206 1.77004528993e-15 ko04080 Neuroactive ligand-receptor interaction 123/1086 423/7206 3.51516508076e-14 ko05032 Morphine addiction 47/1086 110/7206 1.94502540939e-12 ko04020 Calcium signaling pathway 84/1086 265/7206 4.18200105312e-12 ko04713 Circadian entrainment 53/1086 136/7206 5.94493777241e-12 ko04024 cAMP signaling pathway 85/1086 279/7206 3.03712621549e-11 ko04727 GABAergic synapse 45/1086 110/7206 3.50299781469e-11 ko04921 Oxytocin signaling pathway 69/1086 209/7206 4.37970990932e-11 ko05033 Nicotine addiction 29/1086 56/7206 1.24696790941e-10 ko04725 Cholinergic synapse 56/1086 160/7206 3.11586603522e-10 ko04728 Dopaminergic synapse 61/1086 185/7206 8.69738558504e-10 ko04721 Synaptic vesicle cycle 34/1086 80/7206 2.74430274345e-09 ko04022 cGMP-PKG signaling pathway 66/1086 216/7206 5.25739324333e-09 ko04744 Phototransduction 20/1086 36/7206 2.02046125989e-08 ko04911 Insulin secretion 42/1086 117/7206 2.14084576743e-08 ko03010 Ribosome 1/1086 129/7206 2.86968087315e-08 ko03040 Spliceosome 3/1086 145/7206 2.28622533543e-07 ko04723 Retrograde endocannabinoid signaling 53/1086 175/7206 2.62128412516e-07 ko04726 Serotonergic synapse 44/1086 137/7206 3.78978234897e-07 ko04970 Salivary secretion 34/1086 95/7206 5.93462298565e-07 ko04720 Long-term potentiation 34/1086 99/7206 1.38090840785e-06 ko04261 Adrenergic signaling in cardiomyocytes 57/1086 205/7206 2.20501790643e-06 ko05203 Viral carcinogenesis 17/1086 277/7206 4.52396656798e-06 ko05322 Systemic lupus erythematosus 5/1086 151/7206 4.65414432135e-06 ko05031 Amphetamine addiction 31/1086 91/7206 4.91529951848e-06 ko04072 Phospholipase D signaling pathway 54/1086 197/7206 6.405952405e-06 ko04070 Phosphatidylinositol signaling system 35/1086 112/7206 1.25363970703e-05 ko03013 RNA transport 7/1086 166/7206 1.32888009335e-05 ko04730 Long-term depression 27/1086 78/7206 1.61682722576e-05 ko04710 Circadian rhythm 18/1086 43/7206 1.99230394699e-05 ko04925 Aldosterone synthesis and secretion 33/1086 105/7206 2.22861375403e-05 ko04971 Gastric acid secretion 31/1086 98/7206 4.22868904844e-05 ko04110 Cell cycle 6/1086 145/7206 4.93532221912e-05 ko03008 Ribosome biogenesis in eukaryotes 1/1086 79/7206 5.25573597967e-05 ko04745 Phototransduction - fly 16/1086 38/7206 5.28237213431e-05 ko04924 Renin secretion 27/1086 86/7206 0.000107363691069 ko04922 Glucagon signaling pathway 36/1086 128/7206 0.000140484488477 ko04966 Collecting duct acid secretion 12/1086 26/7206 0.000160018488362 ko04514 Cell adhesion molecules (CAMs) 36/1086 130/7206 0.000170403978741 ko04371 Apelin signaling pathway 45/1086 177/7206 0.000262392042268 ko04141 Protein processing in endoplasmic reticulum 13/1086 184/7206 0.00114262824416 ko04742 Taste transduction 19/1086 61/7206 0.00165581540215 ko05169 Epstein-Barr virus infection 16/1086 206/7206 0.00205395294166 ko00520 Amino sugar and nucleotide sugar metabolism 1/1086 55/7206 0.0020957181031 ko04626 Plant-pathogen interaction 8/1086 18/7206 0.00276670013582 ko04750 Inflammatory mediator regulation of TRP channels 31/1086 122/7206 0.00296784325391 ko04014 Ras signaling pathway 60/1086 279/7206 0.00355677544543 ko04120 Ubiquitin mediated proteolysis 9/1086 138/7206 0.00358617328402 ko04010 MAPK signaling pathway 67/1086 321/7206 0.00400710967557 ko04015 Rap1 signaling pathway 59/1086 278/7206 0.00470963322124 ko04964 Proximal tubule bicarbonate reclamation 10/1086 29/7206 0.00755178321667 ko05168 Herpes simplex infection 15/1086 182/7206 0.00830608759534 ko05016 Huntington's disease 19/1086 215/7206 0.00865196062485 ko04657 IL-17 signaling pathway 5/1086 87/7206 0.010139717567 ko04972 Pancreatic secretion 27/1086 111/7206 0.010317061528 ko03022 Basal transcription factors 1/1086 44/7206 0.0104731271319 ko03420 Nucleotide excision repair 1/1086 46/7206 0.0110264433527 ko04270 Vascular smooth muscle contraction 35/1086 154/7206 0.0116633941949 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1086 14/7206 0.0117144534185 ko00965 Betalain biosynthesis 3/1086 4/7206 0.0121195167658 ko05110 Vibrio cholerae infection 17/1086 63/7206 0.0124875898985 ko03050 Proteasome 2/1086 54/7206 0.0127385776672 ko05030 Cocaine addiction 19/1086 73/7206 0.0129606916228 ko04623 Cytosolic DNA-sensing pathway 1/1086 41/7206 0.0156193822766 ko05323 Rheumatoid arthritis 22/1086 89/7206 0.0160615471597 ko04915 Estrogen signaling pathway 30/1086 131/7206 0.0183070178223 ko05230 Central carbon metabolism in cancer 20/1086 81/7206 0.0191629660326 ko04214 Apoptosis - fly 4/1086 72/7206 0.0196742040417 ko04360 Axon guidance 48/1086 233/7206 0.0197821232188 ko00240 Pyrimidine metabolism 8/1086 110/7206 0.0214025816864 ko04540 Gap junction 29/1086 128/7206 0.0238213024775 ko04923 Regulation of lipolysis in adipocytes 19/1086 77/7206 0.0241072921536 ko04960 Aldosterone-regulated sodium reabsorption 12/1086 41/7206 0.0249951660514 ko04113 Meiosis - yeast 4/1086 70/7206 0.0275205631036 ko04550 Signaling pathways regulating pluripotency of stem cells 15/1086 165/7206 0.0275646038427 ko00680 Methane metabolism 10/1086 34/7206 0.0282384437135 ko04064 NF-kappa B signaling pathway 7/1086 96/7206 0.0305160108866 ko04621 NOD-like receptor signaling pathway 14/1086 157/7206 0.0313111231139 ko00564 Glycerophospholipid metabolism 23/1086 99/7206 0.0323948248673 ko00010 Glycolysis / Gluconeogenesis 18/1086 74/7206 0.0327320621063 ko04711 Circadian rhythm - fly 5/1086 13/7206 0.0346599943649 ko00562 Inositol phosphate metabolism 21/1086 89/7206 0.035151893876 ko04341 Hedgehog signaling pathway - fly 1/1086 38/7206 0.0364581334792 ko03410 Base excision repair 1/1086 38/7206 0.0364581334792 ko04350 TGF-beta signaling pathway 8/1086 103/7206 0.0367134264477 ko02010 ABC transporters 11/1086 39/7206 0.0388257125351 ko04740 Olfactory transduction 19/1086 80/7206 0.0394019831875 ko05219 Bladder cancer 2/1086 48/7206 0.0396181383539 ko04666 Fc gamma R-mediated phagocytosis 27/1086 122/7206 0.0398349762849 ko04137 Mitophagy - animal 19/1086 82/7206 0.0439636068293 ko04260 Cardiac muscle contraction 22/1086 98/7206 0.0461514997803 ko05164 Influenza A 16/1086 167/7206 0.0481631940375