ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 26/401 80/7206 5.19255283129e-14 ko04713 Circadian entrainment 29/401 136/7206 2.10230890201e-10 ko04728 Dopaminergic synapse 33/401 185/7206 1.6196727768e-09 ko04966 Collecting duct acid secretion 12/401 26/7206 3.55768612747e-09 ko04724 Glutamatergic synapse 28/401 152/7206 1.41050017089e-08 ko04727 GABAergic synapse 23/401 110/7206 2.44515706233e-08 ko04720 Long-term potentiation 21/401 99/7206 7.72663263719e-08 ko04911 Insulin secretion 23/401 117/7206 8.24175352375e-08 ko04921 Oxytocin signaling pathway 32/401 209/7206 1.28921968331e-07 ko05110 Vibrio cholerae infection 16/401 63/7206 2.05572207161e-07 ko05033 Nicotine addiction 15/401 56/7206 2.32440141804e-07 ko04261 Adrenergic signaling in cardiomyocytes 31/401 205/7206 2.71809333484e-07 ko04024 cAMP signaling pathway 38/401 279/7206 2.80076403312e-07 ko00190 Oxidative phosphorylation 23/401 127/7206 3.9322993528e-07 ko05031 Amphetamine addiction 19/401 91/7206 4.2228187475e-07 ko04080 Neuroactive ligand-receptor interaction 49/401 423/7206 8.65557175442e-07 ko05032 Morphine addiction 20/401 110/7206 2.13635243625e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/401 92/7206 2.32118881976e-06 ko04970 Salivary secretion 18/401 95/7206 3.76233003322e-06 ko04723 Retrograde endocannabinoid signaling 25/401 175/7206 1.12623192801e-05 ko04725 Cholinergic synapse 23/401 160/7206 2.28744149224e-05 ko04022 cGMP-PKG signaling pathway 28/401 216/7206 2.529347825e-05 ko04726 Serotonergic synapse 20/401 137/7206 6.25413306052e-05 ko05323 Rheumatoid arthritis 15/401 89/7206 0.000100509440299 ko04626 Plant-pathogen interaction 6/401 18/7206 0.00029941393113 ko04730 Long-term depression 13/401 78/7206 0.000324926700526 ko04060 Cytokine-cytokine receptor interaction 1/401 191/7206 0.000331280238764 ko04371 Apelin signaling pathway 22/401 177/7206 0.000341237450447 ko04020 Calcium signaling pathway 29/401 265/7206 0.000499217222874 ko04925 Aldosterone synthesis and secretion 15/401 105/7206 0.000647970578661 ko00010 Glycolysis / Gluconeogenesis 12/401 74/7206 0.000707864610497 ko05014 Amyotrophic lateral sclerosis (ALS) 12/401 74/7206 0.000707864610497 ko05168 Herpes simplex infection 1/401 182/7206 0.000766562465496 ko04745 Phototransduction - fly 8/401 38/7206 0.000958111799791 ko04070 Phosphatidylinositol signaling system 15/401 112/7206 0.0012797736447 ko05164 Influenza A 1/401 167/7206 0.00161439700111 ko04114 Oocyte meiosis 17/401 139/7206 0.00205956135045 ko00680 Methane metabolism 7/401 34/7206 0.00227795840471 ko04145 Phagosome 19/401 162/7206 0.00247901549334 ko04922 Glucagon signaling pathway 16/401 128/7206 0.00248531048198 ko05010 Alzheimer's disease 22/401 202/7206 0.00254331396995 ko04924 Renin secretion 12/401 86/7206 0.00269932876578 ko04971 Gastric acid secretion 13/401 98/7206 0.00288386131945 ko04744 Phototransduction 7/401 36/7206 0.00321124747102 ko04740 Olfactory transduction 11/401 80/7206 0.00449412294052 ko04972 Pancreatic secretion 14/401 111/7206 0.00490037818734 ko04138 Autophagy - yeast 11/401 81/7206 0.00494820788255 ko03040 Spliceosome 1/401 145/7206 0.00495302719055 ko05034 Alcoholism 24/401 238/7206 0.00556198221171 ko05166 HTLV-I infection 6/401 292/7206 0.00562498766115 ko01230 Biosynthesis of amino acids 11/401 85/7206 0.00713952854849 ko04014 Ras signaling pathway 26/401 279/7206 0.0104821368209 ko04630 Jak-STAT signaling pathway 1/401 132/7206 0.0107119415692 ko04260 Cardiac muscle contraction 12/401 98/7206 0.0113887730871 ko04360 Axon guidance 22/401 233/7206 0.0130236360243 ko04668 TNF signaling pathway 1/401 120/7206 0.0145887967532 ko04010 MAPK signaling pathway 28/401 321/7206 0.0171531052016 ko05322 Systemic lupus erythematosus 2/401 151/7206 0.0177433942108 ko04742 Taste transduction 8/401 61/7206 0.0189508415606 ko05169 Epstein-Barr virus infection 4/401 206/7206 0.0192254284691 ko04964 Proximal tubule bicarbonate reclamation 5/401 29/7206 0.0204414736926 ko04978 Mineral absorption 6/401 40/7206 0.0220035018166 ko04016 MAPK signaling pathway - plant 4/401 20/7206 0.0224966159129 ko04960 Aldosterone-regulated sodium reabsorption 6/401 41/7206 0.0246082932882 ko05161 Hepatitis B 3/401 173/7206 0.0267428592154 ko00051 Fructose and mannose metabolism 6/401 42/7206 0.0274113171257 ko04940 Type I diabetes mellitus 5/401 32/7206 0.0302681647027 ko01200 Carbon metabolism 13/401 128/7206 0.0306693239147 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/401 59/7206 0.0441352440077 ko05203 Viral carcinogenesis 8/401 277/7206 0.0447567349013 ko04750 Inflammatory mediator regulation of TRP channels 12/401 122/7206 0.0455633451842 ko04210 Apoptosis 4/401 180/7206 0.0468124614673 ko02024 Quorum sensing 3/401 15/7206 0.0472351049045 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/401 15/7206 0.0472351049045