ko pathway ratio_in_study ratio_in_pop p_value ko04974 Protein digestion and absorption 27/414 96/7206 1.85920901448e-12 ko04080 Neuroactive ligand-receptor interaction 58/414 423/7206 2.34356189041e-10 ko05033 Nicotine addiction 18/414 56/7206 9.0540211605e-10 ko04512 ECM-receptor interaction 20/414 79/7206 1.10815486417e-08 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/414 79/7206 1.71766035261e-06 ko04950 Maturity onset diabetes of the young 9/414 29/7206 2.23387288165e-05 ko04260 Cardiac muscle contraction 17/414 98/7206 3.57232508985e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 17/414 100/7206 4.67207804096e-05 ko04727 GABAergic synapse 18/414 110/7206 4.75472646619e-05 ko04978 Mineral absorption 10/414 40/7206 6.27356151973e-05 ko04020 Calcium signaling pathway 31/414 265/7206 0.000128434995525 ko04510 Focal adhesion 29/414 240/7206 0.000172730248429 ko04713 Circadian entrainment 19/414 136/7206 0.000260794141208 ko05168 Herpes simplex infection 1/414 182/7206 0.000505632298805 ko05414 Dilated cardiomyopathy 16/414 112/7206 0.000613260065181 ko05161 Hepatitis B 1/414 173/7206 0.000718130465404 ko00430 Taurine and hypotaurine metabolism 5/414 14/7206 0.000793567036879 ko04911 Insulin secretion 16/414 117/7206 0.000996280856135 ko04964 Proximal tubule bicarbonate reclamation 7/414 29/7206 0.00101583653392 ko04140 Autophagy - animal 1/414 164/7206 0.00103856787449 ko05164 Influenza A 1/414 167/7206 0.00106442818246 ko04151 PI3K-Akt signaling pathway 38/414 390/7206 0.00109575426124 ko04724 Glutamatergic synapse 19/414 152/7206 0.00117829703224 ko04723 Retrograde endocannabinoid signaling 21/414 175/7206 0.00134665006547 ko04150 mTOR signaling pathway 2/414 184/7206 0.00208123618774 ko05203 Viral carcinogenesis 5/414 277/7206 0.00215248118296 ko05014 Amyotrophic lateral sclerosis (ALS) 11/414 74/7206 0.00309837711936 ko04110 Cell cycle 1/414 145/7206 0.00327381817176 ko04022 cGMP-PKG signaling pathway 23/414 216/7206 0.00414991705586 ko04120 Ubiquitin mediated proteolysis 1/414 138/7206 0.00476797588146 ko04062 Chemokine signaling pathway 3/414 201/7206 0.00499222398104 ko00250 Alanine, aspartate and glutamate metabolism 7/414 38/7206 0.00525452120803 ko04261 Adrenergic signaling in cardiomyocytes 22/414 205/7206 0.00529264569501 ko04976 Bile secretion 11/414 80/7206 0.00570510896734 ko04360 Axon guidance 24/414 233/7206 0.00578435439796 ko04921 Oxytocin signaling pathway 22/414 209/7206 0.00582164345998 ko03013 RNA transport 2/414 166/7206 0.00611838766508 ko04060 Cytokine-cytokine receptor interaction 3/414 191/7206 0.00687304895525 ko04742 Taste transduction 9/414 61/7206 0.00756120313627 ko05166 HTLV-I infection 7/414 292/7206 0.0095781653647 ko05152 Tuberculosis 3/414 187/7206 0.0097744904886 ko05322 Systemic lupus erythematosus 2/414 151/7206 0.0122493660961 ko04024 cAMP signaling pathway 26/414 279/7206 0.0124676019339 ko04730 Long-term depression 10/414 78/7206 0.013272095293 ko04726 Serotonergic synapse 15/414 137/7206 0.0144104652759 ko04924 Renin secretion 11/414 86/7206 0.0157728005702 ko04144 Endocytosis 10/414 342/7206 0.0171518626938 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/414 59/7206 0.0187055348486 ko04072 Phospholipase D signaling pathway 4/414 197/7206 0.0188342335079 ko04514 Cell adhesion molecules (CAMs) 14/414 130/7206 0.0206124041979 ko00240 Pyrimidine metabolism 1/414 110/7206 0.0211195910854 ko04721 Synaptic vesicle cycle 10/414 80/7206 0.0242554323018 ko04740 Olfactory transduction 10/414 80/7206 0.0242554323018 ko04728 Dopaminergic synapse 18/414 185/7206 0.0244003635517 ko04725 Cholinergic synapse 16/414 160/7206 0.0252679030991 ko04010 MAPK signaling pathway 28/414 321/7206 0.0262269838435 ko01521 EGFR tyrosine kinase inhibitor resistance 1/414 106/7206 0.0316376084787 ko05032 Morphine addiction 12/414 110/7206 0.0345320065493 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/414 182/7206 0.0346534553682 ko04630 Jak-STAT signaling pathway 2/414 132/7206 0.0349357679899 ko04141 Protein processing in endoplasmic reticulum 4/414 184/7206 0.0350293982352 ko05030 Cocaine addiction 9/414 73/7206 0.0361812835338 ko05202 Transcriptional misregulation in cancer 18/414 188/7206 0.0365206930181 ko05416 Viral myocarditis 7/414 55/7206 0.0367560052738 ko00350 Tyrosine metabolism 5/414 33/7206 0.0383750003533 ko05031 Amphetamine addiction 10/414 91/7206 0.0396145031732 ko00564 Glycerophospholipid metabolism 1/414 99/7206 0.0455503196143 ko04211 Longevity regulating pathway 2/414 123/7206 0.0480933425513