ko pathway ratio_in_study ratio_in_pop p_value ko04512 ECM-receptor interaction 25/396 79/7206 2.41647965823e-13 ko04510 Focal adhesion 36/396 240/7206 2.52860644905e-08 ko04974 Protein digestion and absorption 20/396 96/7206 1.76774156357e-07 ko00643 Styrene degradation 4/396 4/7206 8.99012420559e-06 ko00350 Tyrosine metabolism 9/396 33/7206 4.94481246493e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 16/396 100/7206 9.73301994515e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/396 135/7206 0.000132837972013 ko04610 Complement and coagulation cascades 13/396 79/7206 0.000327375521844 ko04022 cGMP-PKG signaling pathway 25/396 216/7206 0.000364025592299 ko05414 Dilated cardiomyopathy 16/396 112/7206 0.000375384770042 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/396 4/7206 0.000632122397387 ko04020 Calcium signaling pathway 28/396 265/7206 0.000804463800377 ko05146 Amoebiasis 14/396 99/7206 0.000954174531509 ko04060 Cytokine-cytokine receptor interaction 22/396 191/7206 0.000964745794994 ko04270 Vascular smooth muscle contraction 18/396 154/7206 0.00202499223867 ko04672 Intestinal immune network for IgA production 7/396 37/7206 0.00352052249679 ko04151 PI3K-Akt signaling pathway 35/396 390/7206 0.00395212597863 ko03040 Spliceosome 1/396 145/7206 0.00483817427158 ko04110 Cell cycle 1/396 145/7206 0.00483817427158 ko00230 Purine metabolism 20/396 194/7206 0.00593589338436 ko00010 Glycolysis / Gluconeogenesis 10/396 74/7206 0.00686709890356 ko04120 Ubiquitin mediated proteolysis 1/396 138/7206 0.00705596445186 ko00051 Fructose and mannose metabolism 7/396 42/7206 0.00728639245493 ko00565 Ether lipid metabolism 7/396 42/7206 0.00728639245493 ko04710 Circadian rhythm 7/396 43/7206 0.00830321391518 ko03013 RNA transport 2/396 166/7206 0.00873752939544 ko05145 Toxoplasmosis 14/396 126/7206 0.0097672070856 ko05203 Viral carcinogenesis 6/396 277/7206 0.00996261570368 ko03010 Ribosome 1/396 129/7206 0.0100936334993 ko05144 Malaria 7/396 45/7206 0.0106444575102 ko00360 Phenylalanine metabolism 4/396 17/7206 0.0120739528893 ko03320 PPAR signaling pathway 9/396 69/7206 0.012645986657 ko00710 Carbon fixation in photosynthetic organisms 5/396 27/7206 0.0144724354039 ko00950 Isoquinoline alkaloid biosynthesis 3/396 10/7206 0.0147955887079 ko05322 Systemic lupus erythematosus 2/396 151/7206 0.0174660535475 ko04380 Osteoclast differentiation 14/396 134/7206 0.0193072483544 ko00561 Glycerolipid metabolism 8/396 63/7206 0.0211778088836 ko00120 Primary bile acid biosynthesis 4/396 20/7206 0.0215848105734 ko04611 Platelet activation 16/396 163/7206 0.0221030436192 ko04640 Hematopoietic cell lineage 8/396 64/7206 0.0230867071889 ko00140 Steroid hormone biosynthesis 6/396 41/7206 0.023296302215 ko04723 Retrograde endocannabinoid signaling 3/396 175/7206 0.0267124615613 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/396 5/7206 0.026964996159 ko04670 Leukocyte transendothelial migration 15/396 151/7206 0.0274431311769 ko00030 Pentose phosphate pathway 5/396 32/7206 0.028868509668 ko04921 Oxytocin signaling pathway 19/396 209/7206 0.0294088512935 ko04514 Cell adhesion molecules (CAMs) 13/396 130/7206 0.0311589373798 ko05321 Inflammatory bowel disease (IBD) 7/396 56/7206 0.0325634415833 ko00760 Nicotinate and nicotinamide metabolism 5/396 34/7206 0.0364969075427 ko00620 Pyruvate metabolism 6/396 46/7206 0.0386393947782 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/396 79/7206 0.039691294136 ko00500 Starch and sucrose metabolism 5/396 35/7206 0.0407334388228 ko04658 Th1 and Th2 cell differentiation 10/396 96/7206 0.0415287964558 ko04261 Adrenergic signaling in cardiomyocytes 18/396 205/7206 0.0426986316788