ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 12/372 30/7206 1.1171951057e-08 ko04380 Osteoclast differentiation 23/372 134/7206 2.79947699662e-07 ko04064 NF-kappa B signaling pathway 19/372 96/7206 3.18606116294e-07 ko05164 Influenza A 25/372 167/7206 1.23897846199e-06 ko04621 NOD-like receptor signaling pathway 24/372 157/7206 1.38449583475e-06 ko04060 Cytokine-cytokine receptor interaction 27/372 191/7206 1.46387776944e-06 ko04650 Natural killer cell mediated cytotoxicity 18/372 97/7206 1.7637054569e-06 ko05145 Toxoplasmosis 20/372 126/7206 5.92879168383e-06 ko05162 Measles 19/372 120/7206 1.05385623598e-05 ko04660 T cell receptor signaling pathway 19/372 124/7206 1.70931710968e-05 ko04658 Th1 and Th2 cell differentiation 16/372 96/7206 2.74269724112e-05 ko04662 B cell receptor signaling pathway 15/372 88/7206 3.71838674038e-05 ko05140 Leishmaniasis 13/372 75/7206 0.000102450850809 ko05321 Inflammatory bowel disease (IBD) 11/372 56/7206 0.000109055939537 ko04610 Complement and coagulation cascades 13/372 79/7206 0.000177042567827 ko05152 Tuberculosis 22/372 187/7206 0.000277538703136 ko04659 Th17 cell differentiation 15/372 106/7206 0.000324837628181 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/372 191/7206 0.000351895060511 ko05150 Staphylococcus aureus infection 8/372 36/7206 0.000395442059239 ko04611 Platelet activation 20/372 163/7206 0.000415410741091 ko04630 Jak-STAT signaling pathway 17/372 132/7206 0.000416159669827 ko05168 Herpes simplex infection 21/372 182/7206 0.000479087486321 ko04620 Toll-like receptor signaling pathway 14/372 100/7206 0.000570623223967 ko04217 Necroptosis 20/372 178/7206 0.000880932764461 ko05330 Allograft rejection 6/372 24/7206 0.0011061773484 ko04390 Hippo signaling pathway 1/372 188/7206 0.0011257592582 ko05160 Hepatitis C 18/372 153/7206 0.00112993321211 ko04668 TNF signaling pathway 15/372 120/7206 0.00122652170239 ko05161 Hepatitis B 19/372 173/7206 0.00152199173598 ko04664 Fc epsilon RI signaling pathway 11/372 77/7206 0.00184955275669 ko03013 RNA transport 1/372 166/7206 0.00226263409346 ko04672 Intestinal immune network for IgA production 7/372 37/7206 0.00247685839919 ko05034 Alcoholism 3/372 238/7206 0.00253467850135 ko05320 Autoimmune thyroid disease 6/372 29/7206 0.00313743774447 ko04622 RIG-I-like receptor signaling pathway 9/372 62/7206 0.00422105398684 ko00140 Steroid hormone biosynthesis 7/372 41/7206 0.0045298547521 ko00590 Arachidonic acid metabolism 8/372 52/7206 0.00478197298527 ko05133 Pertussis 11/372 87/7206 0.00489184626272 ko04666 Fc gamma R-mediated phagocytosis 14/372 122/7206 0.005414502248 ko04612 Antigen processing and presentation 10/372 77/7206 0.00591790070986 ko04710 Circadian rhythm 7/372 43/7206 0.00594335411293 ko03040 Spliceosome 1/372 145/7206 0.00701243893033 ko04110 Cell cycle 1/372 145/7206 0.00701243893033 ko05144 Malaria 7/372 45/7206 0.00766269598022 ko05142 Chagas disease (American trypanosomiasis) 14/372 130/7206 0.00790245683769 ko04723 Retrograde endocannabinoid signaling 2/372 175/7206 0.00873083727409 ko04062 Chemokine signaling pathway 19/372 201/7206 0.0091466314516 ko05131 Shigellosis 10/372 82/7206 0.00919170106527 ko04137 Mitophagy - animal 10/372 82/7206 0.00919170106527 ko05310 Asthma 4/372 17/7206 0.0097310204664 ko04145 Phagosome 16/372 162/7206 0.0109334071058 ko05332 Graft-versus-host disease 4/372 18/7206 0.0120116178567 ko04670 Leukocyte transendothelial migration 15/372 151/7206 0.0138437750546 ko00592 alpha-Linolenic acid metabolism 4/372 19/7206 0.0146082245679 ko03010 Ribosome 1/372 129/7206 0.014709513466 ko04210 Apoptosis 17/372 180/7206 0.0152634699974 ko05132 Salmonella infection 11/372 98/7206 0.0171743002086 ko00120 Primary bile acid biosynthesis 4/372 20/7206 0.0175338103663 ko04623 Cytosolic DNA-sensing pathway 6/372 41/7206 0.0176615144931 ko00051 Fructose and mannose metabolism 6/372 42/7206 0.0197383266485 ko03050 Proteasome 7/372 54/7206 0.0201446091253 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/372 5/7206 0.023955011855 ko00350 Tyrosine metabolism 5/372 33/7206 0.0256975464971 ko05414 Dilated cardiomyopathy 1/372 112/7206 0.0306026468301 ko04068 FoxO signaling pathway 15/372 167/7206 0.032218083171 ko04514 Cell adhesion molecules (CAMs) 12/372 130/7206 0.043564655804 ko04917 Prolactin signaling pathway 9/372 87/7206 0.0443795491574 ko05323 Rheumatoid arthritis 9/372 89/7206 0.0480413436001