ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 57/567 191/7206 9.85266278783e-20 ko04380 Osteoclast differentiation 40/567 134/7206 3.72005138701e-14 ko04621 NOD-like receptor signaling pathway 40/567 157/7206 1.06617614976e-11 ko05340 Primary immunodeficiency 15/567 30/7206 1.17038327577e-09 ko04064 NF-kappa B signaling pathway 27/567 96/7206 2.5415690226e-09 ko05164 Influenza A 37/567 167/7206 4.53578998659e-09 ko04630 Jak-STAT signaling pathway 31/567 132/7206 1.96988181272e-08 ko05321 Inflammatory bowel disease (IBD) 19/567 56/7206 2.09595161281e-08 ko05140 Leishmaniasis 22/567 75/7206 3.34816814842e-08 ko04658 Th1 and Th2 cell differentiation 25/567 96/7206 5.4334093281e-08 ko04650 Natural killer cell mediated cytotoxicity 25/567 97/7206 6.7891958674e-08 ko04659 Th17 cell differentiation 26/567 106/7206 1.0990904403e-07 ko05162 Measles 28/567 120/7206 1.12033053049e-07 ko04660 T cell receptor signaling pathway 28/567 124/7206 2.34053879117e-07 ko04672 Intestinal immune network for IgA production 14/567 37/7206 3.32402799431e-07 ko05145 Toxoplasmosis 28/567 126/7206 3.33546136121e-07 ko04610 Complement and coagulation cascades 21/567 79/7206 4.38304047341e-07 ko04620 Toll-like receptor signaling pathway 24/567 100/7206 5.24558667964e-07 ko04640 Hematopoietic cell lineage 18/567 64/7206 1.19332651238e-06 ko04217 Necroptosis 34/567 178/7206 1.23505313399e-06 ko05150 Staphylococcus aureus infection 13/567 36/7206 1.6447815964e-06 ko05168 Herpes simplex infection 34/567 182/7206 1.72664712909e-06 ko04668 TNF signaling pathway 25/567 120/7206 4.96090499224e-06 ko05330 Allograft rejection 10/567 24/7206 5.99001152394e-06 ko00120 Primary bile acid biosynthesis 9/567 20/7206 8.28498076224e-06 ko05152 Tuberculosis 33/567 187/7206 1.06546134085e-05 ko04612 Antigen processing and presentation 18/567 77/7206 2.05521566885e-05 ko05144 Malaria 13/567 45/7206 2.68086251331e-05 ko03013 RNA transport 1/567 166/7206 2.83497455565e-05 ko05133 Pertussis 19/567 87/7206 3.39795191347e-05 ko04662 B cell receptor signaling pathway 19/567 88/7206 4.02235603352e-05 ko05320 Autoimmune thyroid disease 10/567 29/7206 4.26191642642e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/567 191/7206 5.09791261228e-05 ko05161 Hepatitis B 29/567 173/7206 8.09311481003e-05 ko03040 Spliceosome 1/567 145/7206 0.000135920492142 ko00590 Arachidonic acid metabolism 13/567 52/7206 0.000139602036112 ko05310 Asthma 7/567 17/7206 0.00017402462165 ko04210 Apoptosis 29/567 180/7206 0.000193306106693 ko05034 Alcoholism 5/567 238/7206 0.000195572556108 ko04622 RIG-I-like receptor signaling pathway 14/567 62/7206 0.000250649332379 ko04390 Hippo signaling pathway 3/567 188/7206 0.000282525607192 ko05160 Hepatitis C 25/567 153/7206 0.000379850954321 ko03010 Ribosome 1/567 129/7206 0.000693461630102 ko05142 Chagas disease (American trypanosomiasis) 22/567 130/7206 0.000720597580479 ko04062 Chemokine signaling pathway 30/567 201/7206 0.00072538558276 ko04110 Cell cycle 2/567 145/7206 0.000927182292973 ko04623 Cytosolic DNA-sensing pathway 10/567 41/7206 0.00100709888906 ko04611 Platelet activation 25/567 163/7206 0.00103955011075 ko05332 Graft-versus-host disease 6/567 18/7206 0.00188848290313 ko05323 Rheumatoid arthritis 16/567 89/7206 0.00202970484844 ko04723 Retrograde endocannabinoid signaling 4/567 175/7206 0.00257845250152 ko00592 alpha-Linolenic acid metabolism 6/567 19/7206 0.00257904719097 ko00350 Tyrosine metabolism 8/567 33/7206 0.00332517962479 ko04728 Dopaminergic synapse 5/567 185/7206 0.00518176678028 ko04137 Mitophagy - animal 14/567 82/7206 0.00555944129108 ko05418 Fluid shear stress and atherosclerosis 24/567 173/7206 0.00598066248188 ko04916 Melanogenesis 3/567 142/7206 0.00660164243598 ko04310 Wnt signaling pathway 5/567 181/7206 0.00718405578364 ko04068 FoxO signaling pathway 23/567 167/7206 0.00803063762154 ko04657 IL-17 signaling pathway 14/567 87/7206 0.00829716854274 ko04666 Fc gamma R-mediated phagocytosis 18/567 122/7206 0.00954419501342 ko05132 Salmonella infection 15/567 98/7206 0.0121074857497 ko05146 Amoebiasis 15/567 99/7206 0.0127824268195 ko05134 Legionellosis 12/567 74/7206 0.0143680378498 ko04664 Fc epsilon RI signaling pathway 12/567 77/7206 0.018135195727 ko04721 Synaptic vesicle cycle 1/567 80/7206 0.0198976208579 ko04740 Olfactory transduction 1/567 80/7206 0.0198976208579 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/567 135/7206 0.0232455398211 ko04114 Oocyte meiosis 4/567 139/7206 0.0245811226687 ko04145 Phagosome 21/567 162/7206 0.0251257734121 ko05224 Breast cancer 6/567 174/7206 0.0308467927709 ko04724 Glutamatergic synapse 5/567 152/7206 0.031899133454 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/567 4/7206 0.033322692354 ko00643 Styrene degradation 2/567 4/7206 0.033322692354 ko04713 Circadian entrainment 4/567 136/7206 0.0343295387481 ko05131 Shigellosis 12/567 82/7206 0.0352501467395 ko04940 Type I diabetes mellitus 6/567 32/7206 0.0360620351793 ko05143 African trypanosomiasis 6/567 32/7206 0.0360620351793 ko00950 Isoquinoline alkaloid biosynthesis 3/567 10/7206 0.0382912428757 ko00140 Steroid hormone biosynthesis 7/567 41/7206 0.0388051152863 ko00360 Phenylalanine metabolism 4/567 17/7206 0.0395954531378 ko00983 Drug metabolism - other enzymes 7/567 42/7206 0.0435391790682 ko00051 Fructose and mannose metabolism 7/567 42/7206 0.0435391790682 ko04670 Leukocyte transendothelial migration 19/567 151/7206 0.0447223233544 ko04530 Tight junction 10/567 228/7206 0.0452840018976 ko04727 GABAergic synapse 3/567 110/7206 0.047015547688 ko05032 Morphine addiction 3/567 110/7206 0.047015547688