ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1313	423/7206	3.48474864759e-53
ko04724	Glutamatergic synapse	98/1313	152/7206	4.25523019662e-37
ko05033	Nicotine addiction	50/1313	56/7206	5.11040220541e-31
ko05032	Morphine addiction	73/1313	110/7206	4.76296393118e-29
ko04713	Circadian entrainment	83/1313	136/7206	5.01524490441e-29
ko04727	GABAergic synapse	70/1313	110/7206	3.18986678276e-26
ko04728	Dopaminergic synapse	92/1313	185/7206	5.09454670844e-23
ko04725	Cholinergic synapse	81/1313	160/7206	5.15188197529e-21
ko04721	Synaptic vesicle cycle	51/1313	80/7206	1.82936369548e-19
ko04723	Retrograde endocannabinoid signaling	83/1313	175/7206	3.38360084131e-19
ko04020	Calcium signaling pathway	107/1313	265/7206	8.49723363455e-18
ko04726	Serotonergic synapse	68/1313	137/7206	3.10221437945e-17
ko04024	cAMP signaling pathway	109/1313	279/7206	7.30027739836e-17
ko04911	Insulin secretion	60/1313	117/7206	3.31679472911e-16
ko04921	Oxytocin signaling pathway	85/1313	209/7206	1.79920550127e-14
ko05031	Amphetamine addiction	48/1313	91/7206	7.95658193682e-14
ko04744	Phototransduction	27/1313	36/7206	1.48849067509e-13
ko04742	Taste transduction	37/1313	61/7206	1.77777308566e-13
ko04720	Long-term potentiation	49/1313	99/7206	1.03935673628e-12
ko03040	Spliceosome	1/1313	145/7206	9.32435671387e-12
ko03010	Ribosome	1/1313	129/7206	2.03285996158e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1313	205/7206	2.81269807792e-10
ko04970	Salivary secretion	43/1313	95/7206	9.67036880226e-10
ko05030	Cocaine addiction	35/1313	73/7206	5.47174521745e-09
ko05322	Systemic lupus erythematosus	5/1313	151/7206	4.47251936823e-08
ko04925	Aldosterone synthesis and secretion	43/1313	105/7206	5.2807162667e-08
ko03013	RNA transport	7/1313	166/7206	1.12070421448e-07
ko04070	Phosphatidylinositol signaling system	44/1313	112/7206	1.62422454754e-07
ko05203	Viral carcinogenesis	20/1313	277/7206	1.7498939622e-07
ko04971	Gastric acid secretion	40/1313	98/7206	1.83607149138e-07
ko04360	Axon guidance	74/1313	233/7206	3.96507297156e-07
ko04060	Cytokine-cytokine receptor interaction	11/1313	191/7206	5.45765918437e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1313	74/7206	2.02950906681e-06
ko04730	Long-term depression	32/1313	78/7206	2.16796096345e-06
ko04022	cGMP-PKG signaling pathway	67/1313	216/7206	3.84741569699e-06
ko04740	Olfactory transduction	32/1313	80/7206	5.66791200956e-06
ko05164	Influenza A	10/1313	167/7206	5.91081788276e-06
ko04745	Phototransduction - fly	19/1313	38/7206	8.15767213452e-06
ko04972	Pancreatic secretion	40/1313	111/7206	8.76028033954e-06
ko04110	Cell cycle	8/1313	145/7206	1.02444950549e-05
ko04010	MAPK signaling pathway	90/1313	321/7206	1.09651153146e-05
ko04072	Phospholipase D signaling pathway	61/1313	197/7206	1.30312515e-05
ko04710	Circadian rhythm	20/1313	43/7206	1.87833514255e-05
ko05168	Herpes simplex infection	13/1313	182/7206	2.35281970197e-05
ko04966	Collecting duct acid secretion	14/1313	26/7206	4.4765834094e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1313	79/7206	4.60019807516e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1313	59/7206	5.16907892859e-05
ko04141	Protein processing in endoplasmic reticulum	14/1313	184/7206	6.04611729759e-05
ko04711	Circadian rhythm - fly	9/1313	13/7206	7.61015811501e-05
ko04924	Renin secretion	31/1313	86/7206	0.0001001813831
ko05162	Measles	7/1313	120/7206	0.000111317743605
ko05169	Epstein-Barr virus infection	18/1313	206/7206	0.000155489217994
ko04540	Gap junction	41/1313	128/7206	0.000174938750216
ko04514	Cell adhesion molecules (CAMs)	41/1313	130/7206	0.000205689337865
ko04750	Inflammatory mediator regulation of TRP channels	39/1313	122/7206	0.000207676885374
ko04621	NOD-like receptor signaling pathway	12/1313	157/7206	0.000220805621012
ko04014	Ras signaling pathway	75/1313	279/7206	0.000257149150962
ko04612	Antigen processing and presentation	3/1313	77/7206	0.000289268696314
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1313	79/7206	0.000317708297497
ko00520	Amino sugar and nucleotide sugar metabolism	1/1313	55/7206	0.0003251510044
ko05110	Vibrio cholerae infection	23/1313	63/7206	0.000480068426666
ko05414	Dilated cardiomyopathy	35/1313	112/7206	0.000754070064761
ko04923	Regulation of lipolysis in adipocytes	26/1313	77/7206	0.000936193475567
ko04610	Complement and coagulation cascades	4/1313	79/7206	0.00105723459242
ko04912	GnRH signaling pathway	37/1313	122/7206	0.00123087758177
ko03420	Nucleotide excision repair	1/1313	46/7206	0.00174571971723
ko04630	Jak-STAT signaling pathway	11/1313	132/7206	0.00195183986345
ko04626	Plant-pathogen interaction	9/1313	18/7206	0.0021499751339
ko05321	Inflammatory bowel disease (IBD)	2/1313	56/7206	0.00250308261222
ko03022	Basal transcription factors	1/1313	44/7206	0.00266243684334
ko04915	Estrogen signaling pathway	38/1313	131/7206	0.00271675944546
ko05144	Malaria	1/1313	45/7206	0.00279994764548
ko04064	NF-kappa B signaling pathway	7/1313	96/7206	0.00320224391522
ko04260	Cardiac muscle contraction	30/1313	98/7206	0.00334065938201
ko00590	Arachidonic acid metabolism	2/1313	52/7206	0.00351603884689
ko04930	Type II diabetes mellitus	19/1313	54/7206	0.00377564922711
ko04622	RIG-I-like receptor signaling pathway	3/1313	62/7206	0.00423477037544
ko05231	Choline metabolism in cancer	38/1313	134/7206	0.00440457687787
ko04976	Bile secretion	25/1313	80/7206	0.00501829399037
ko05161	Hepatitis B	18/1313	173/7206	0.00518517767356
ko04922	Glucagon signaling pathway	36/1313	128/7206	0.00529366825001
ko03018	RNA degradation	6/1313	84/7206	0.00633177554131
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1313	14/7206	0.00681701128932
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1313	100/7206	0.00845041061395
ko05131	Shigellosis	6/1313	82/7206	0.00882514407496
ko04115	p53 signaling pathway	5/1313	74/7206	0.00914908848958
ko03410	Base excision repair	1/1313	38/7206	0.00956158183685
ko04371	Apelin signaling pathway	46/1313	177/7206	0.00999738926716
ko05166	HTLV-I infection	37/1313	292/7206	0.0106080870017
ko04658	Th1 and Th2 cell differentiation	8/1313	96/7206	0.0107112470994
ko00071	Fatty acid degradation	2/1313	45/7206	0.0111954947255
ko04657	IL-17 signaling pathway	7/1313	87/7206	0.0112880687613
ko05133	Pertussis	7/1313	87/7206	0.0112880687613
ko00240	Pyrimidine metabolism	10/1313	110/7206	0.0121130852116
ko00280	Valine, leucine and isoleucine degradation	3/1313	54/7206	0.0122489330273
ko00480	Glutathione metabolism	3/1313	55/7206	0.0126267960647
ko04964	Proximal tubule bicarbonate reclamation	11/1313	29/7206	0.0127105609743
ko05205	Proteoglycans in cancer	34/1313	271/7206	0.0127283539758
ko04960	Aldosterone-regulated sodium reabsorption	14/1313	41/7206	0.0134624629381
ko00860	Porphyrin and chlorophyll metabolism	1/1313	34/7206	0.0138383279416
ko04270	Vascular smooth muscle contraction	40/1313	154/7206	0.0149695385771
ko04973	Carbohydrate digestion and absorption	14/1313	42/7206	0.0157983385604
ko04918	Thyroid hormone synthesis	25/1313	86/7206	0.0158273122248
ko00562	Inositol phosphate metabolism	25/1313	89/7206	0.0188242801374
ko05016	Huntington's disease	26/1313	215/7206	0.0192767533642
ko05145	Toxoplasmosis	13/1313	126/7206	0.019395117809
ko04916	Melanogenesis	37/1313	142/7206	0.0204723953141
ko00290	Valine, leucine and isoleucine biosynthesis	3/1313	4/7206	0.0208579286115
ko05418	Fluid shear stress and atherosclerosis	20/1313	173/7206	0.0214410547642
ko05140	Leishmaniasis	6/1313	75/7206	0.0227282250596
ko04217	Necroptosis	21/1313	178/7206	0.0235036837168
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1313	40/7206	0.0239286368297
ko04120	Ubiquitin mediated proteolysis	15/1313	138/7206	0.0252588699116
ko05222	Small cell lung cancer	8/1313	89/7206	0.0258287130387
ko04214	Apoptosis - fly	6/1313	72/7206	0.0303738266812
ko05340	Primary immunodeficiency	1/1313	30/7206	0.0312405861715
ko00630	Glyoxylate and dicarboxylate metabolism	2/1313	38/7206	0.0346523607279
ko04114	Oocyte meiosis	35/1313	139/7206	0.035188747922
ko05132	Salmonella infection	10/1313	98/7206	0.0353381691646
ko04620	Toll-like receptor signaling pathway	10/1313	100/7206	0.0357380085958
ko05214	Glioma	22/1313	79/7206	0.0385488906915
ko04015	Rap1 signaling pathway	64/1313	278/7206	0.0391503762894
ko03320	PPAR signaling pathway	6/1313	69/7206	0.0406596634325
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1313	15/7206	0.040673621853
ko04113	Meiosis - yeast	6/1313	70/7206	0.0413527820848
ko04142	Lysosome	18/1313	151/7206	0.042763276073
ko04666	Fc gamma R-mediated phagocytosis	31/1313	122/7206	0.0439557007435
ko01212	Fatty acid metabolism	5/1313	60/7206	0.0441508160139
ko04213	Longevity regulating pathway - multiple species	23/1313	86/7206	0.0481636846987
ko05320	Autoimmune thyroid disease	1/1313	29/7206	0.0490454184254