ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	62/473	152/7206	1.31468212417e-34
ko04080	Neuroactive ligand-receptor interaction	91/473	423/7206	7.25569459161e-26
ko05032	Morphine addiction	41/473	110/7206	2.49532775863e-21
ko04727	GABAergic synapse	40/473	110/7206	2.26049752325e-20
ko04723	Retrograde endocannabinoid signaling	49/473	175/7206	3.88198242033e-19
ko04713	Circadian entrainment	43/473	136/7206	4.00827151656e-19
ko05033	Nicotine addiction	28/473	56/7206	4.80749020044e-19
ko04728	Dopaminergic synapse	49/473	185/7206	5.02923305282e-18
ko04020	Calcium signaling pathway	56/473	265/7206	1.22332613623e-15
ko05031	Amphetamine addiction	28/473	91/7206	1.61260394033e-12
ko04024	cAMP signaling pathway	51/473	279/7206	9.54889196424e-12
ko04921	Oxytocin signaling pathway	42/473	209/7206	3.21571933171e-11
ko04742	Taste transduction	21/473	61/7206	9.71482936898e-11
ko04720	Long-term potentiation	26/473	99/7206	5.1702984661e-10
ko04726	Serotonergic synapse	31/473	137/7206	6.41571388244e-10
ko04261	Adrenergic signaling in cardiomyocytes	39/473	205/7206	9.21467531287e-10
ko04725	Cholinergic synapse	33/473	160/7206	2.27414108998e-09
ko05030	Cocaine addiction	21/473	73/7206	4.11889726232e-09
ko04911	Insulin secretion	27/473	117/7206	5.33312795624e-09
ko04925	Aldosterone synthesis and secretion	25/473	105/7206	1.00925331368e-08
ko04915	Estrogen signaling pathway	27/473	131/7206	6.89502276675e-08
ko04022	cGMP-PKG signaling pathway	35/473	216/7206	4.54423657055e-07
ko04970	Salivary secretion	21/473	95/7206	5.95645277851e-07
ko04010	MAPK signaling pathway	45/473	321/7206	1.26620613891e-06
ko04072	Phospholipase D signaling pathway	31/473	197/7206	5.2422933778e-06
ko04721	Synaptic vesicle cycle	17/473	80/7206	1.24478129764e-05
ko04070	Phosphatidylinositol signaling system	20/473	112/7206	3.33939245997e-05
ko05414	Dilated cardiomyopathy	20/473	112/7206	3.33939245997e-05
ko04730	Long-term depression	16/473	78/7206	3.56090124587e-05
ko04923	Regulation of lipolysis in adipocytes	15/473	77/7206	0.000116015884759
ko05203	Viral carcinogenesis	5/473	277/7206	0.000286551259481
ko04972	Pancreatic secretion	18/473	111/7206	0.000291874349484
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	14/473	79/7206	0.000542541507274
ko04971	Gastric acid secretion	16/473	98/7206	0.000579708010502
ko04371	Apelin signaling pathway	24/473	177/7206	0.000582622985473
ko04740	Olfactory transduction	14/473	80/7206	0.000619057347095
ko05168	Herpes simplex infection	2/473	182/7206	0.000685993064577
ko04540	Gap junction	19/473	128/7206	0.00078762595534
ko05014	Amyotrophic lateral sclerosis (ALS)	13/473	74/7206	0.00092522569582
ko05034	Alcoholism	29/473	238/7206	0.00117922230697
ko00562	Inositol phosphate metabolism	14/473	89/7206	0.00182038699913
ko00512	Mucin type O-glycan biosynthesis	7/473	29/7206	0.00220673066831
ko04930	Type II diabetes mellitus	10/473	54/7206	0.00235439363076
ko04912	GnRH signaling pathway	17/473	122/7206	0.00265973496562
ko04213	Longevity regulating pathway - multiple species	13/473	86/7206	0.00374704255512
ko04924	Renin secretion	13/473	86/7206	0.00374704255512
ko05231	Choline metabolism in cancer	18/473	134/7206	0.00385142021966
ko04360	Axon guidance	27/473	233/7206	0.00420076635093
ko04114	Oocyte meiosis	18/473	139/7206	0.00492125462652
ko00513	Various types of N-glycan biosynthesis	8/473	42/7206	0.00528132630283
ko04260	Cardiac muscle contraction	14/473	98/7206	0.00576074748066
ko04110	Cell cycle	2/473	145/7206	0.00595733762634
ko04514	Cell adhesion molecules (CAMs)	17/473	130/7206	0.00613149011476
ko04014	Ras signaling pathway	30/473	279/7206	0.00641709657563
ko03013	RNA transport	3/473	166/7206	0.0067266485071
ko04750	Inflammatory mediator regulation of TRP channels	16/473	122/7206	0.00816986237974
ko04914	Progesterone-mediated oocyte maturation	14/473	104/7206	0.00852078060356
ko04141	Protein processing in endoplasmic reticulum	4/473	184/7206	0.00984158592966
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/473	14/7206	0.0108142859207
ko04630	Jak-STAT signaling pathway	2/473	132/7206	0.0119793652213
ko04621	NOD-like receptor signaling pathway	3/473	157/7206	0.0132793609786
ko04320	Dorso-ventral axis formation	6/473	31/7206	0.0139773917778
ko04350	TGF-beta signaling pathway	1/473	103/7206	0.014359420764
ko00510	N-Glycan biosynthesis	8/473	50/7206	0.015188378121
ko04211	Longevity regulating pathway	15/473	123/7206	0.0164891944076
ko04142	Lysosome	3/473	151/7206	0.018484319838
ko04270	Vascular smooth muscle contraction	18/473	154/7206	0.0193227093696
ko04062	Chemokine signaling pathway	22/473	201/7206	0.0193520236704
ko00515	Mannose type O-glycan biosynthesis	5/473	25/7206	0.0212163298906
ko05410	Hypertrophic cardiomyopathy (HCM)	13/473	100/7206	0.0220099510299
ko05202	Transcriptional misregulation in cancer	5/473	188/7206	0.0243906353049
ko04918	Thyroid hormone synthesis	11/473	86/7206	0.0271156551244
ko04146	Peroxisome	1/473	89/7206	0.029724407625
ko05169	Epstein-Barr virus infection	6/473	206/7206	0.0309663001773
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/473	182/7206	0.0327136286408
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/473	28/7206	0.0334155847551
ko04145	Phagosome	4/473	162/7206	0.0348421554271
ko04916	Melanogenesis	16/473	142/7206	0.037111997776
ko04666	Fc gamma R-mediated phagocytosis	14/473	122/7206	0.0395160436472
ko04976	Bile secretion	10/473	80/7206	0.0398024898965
ko05131	Shigellosis	1/473	82/7206	0.0428393973214
ko04137	Mitophagy - animal	1/473	82/7206	0.0428393973214
ko03018	RNA degradation	1/473	84/7206	0.0432241572081
ko04670	Leukocyte transendothelial migration	4/473	151/7206	0.045945055755
ko05322	Systemic lupus erythematosus	4/473	151/7206	0.045945055755