ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1161	423/7206	2.69275356914e-59
ko05033	Nicotine addiction	50/1161	56/7206	1.11460066907e-33
ko04724	Glutamatergic synapse	84/1161	152/7206	4.75648135654e-29
ko05032	Morphine addiction	69/1161	110/7206	1.16121789523e-28
ko04713	Circadian entrainment	74/1161	136/7206	3.9992858497e-25
ko04727	GABAergic synapse	63/1161	110/7206	3.61630688805e-23
ko04728	Dopaminergic synapse	83/1161	185/7206	8.16040680545e-21
ko04024	cAMP signaling pathway	108/1161	279/7206	1.3068772982e-20
ko04020	Calcium signaling pathway	102/1161	265/7206	3.92185677007e-19
ko04725	Cholinergic synapse	73/1161	160/7206	6.09098893808e-19
ko04723	Retrograde endocannabinoid signaling	75/1161	175/7206	1.64717844434e-17
ko04721	Synaptic vesicle cycle	46/1161	80/7206	2.50444259206e-17
ko04911	Insulin secretion	55/1161	117/7206	2.93955609026e-15
ko04726	Serotonergic synapse	57/1161	137/7206	6.26921006622e-13
ko04742	Taste transduction	34/1161	61/7206	1.32258994119e-12
ko04921	Oxytocin signaling pathway	74/1161	209/7206	4.67549518605e-12
ko05031	Amphetamine addiction	42/1161	91/7206	1.25899669902e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1161	205/7206	5.10723180164e-11
ko04360	Axon guidance	76/1161	233/7206	2.67641620183e-10
ko03040	Spliceosome	1/1161	145/7206	3.14791026702e-10
ko04744	Phototransduction	22/1161	36/7206	1.16147528245e-09
ko04720	Long-term potentiation	41/1161	99/7206	1.36048434355e-09
ko04970	Salivary secretion	39/1161	95/7206	4.64734566652e-09
ko05030	Cocaine addiction	32/1161	73/7206	1.70620637902e-08
ko04925	Aldosterone synthesis and secretion	40/1161	105/7206	4.53896190255e-08
ko04022	cGMP-PKG signaling pathway	66/1161	216/7206	8.13992432649e-08
ko03013	RNA transport	5/1161	166/7206	8.70891084913e-08
ko04740	Olfactory transduction	32/1161	80/7206	2.31976593105e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1161	74/7206	3.90537450306e-07
ko05322	Systemic lupus erythematosus	5/1161	151/7206	8.84265880967e-07
ko04010	MAPK signaling pathway	85/1161	321/7206	1.1931974244e-06
ko05203	Viral carcinogenesis	18/1161	277/7206	1.56275626219e-06
ko04971	Gastric acid secretion	34/1161	98/7206	5.26263291748e-06
ko04060	Cytokine-cytokine receptor interaction	10/1161	191/7206	5.29474836797e-06
ko05164	Influenza A	8/1161	167/7206	9.14607956332e-06
ko05168	Herpes simplex infection	10/1161	182/7206	1.44997438586e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1161	79/7206	2.07333984243e-05
ko04070	Phosphatidylinositol signaling system	36/1161	112/7206	2.23887876263e-05
ko04514	Cell adhesion molecules (CAMs)	39/1161	130/7206	5.6937664171e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1161	122/7206	8.66955401105e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1161	59/7206	9.43454403257e-05
ko04621	NOD-like receptor signaling pathway	9/1161	157/7206	0.00010305231632
ko04072	Phospholipase D signaling pathway	53/1161	197/7206	0.000106558241149
ko04972	Pancreatic secretion	34/1161	111/7206	0.000120532151291
ko04745	Phototransduction - fly	16/1161	38/7206	0.000120784720502
ko04730	Long-term depression	26/1161	78/7206	0.000146561482821
ko04540	Gap junction	37/1161	128/7206	0.000226453901861
ko04612	Antigen processing and presentation	2/1161	77/7206	0.000257954935038
ko04014	Ras signaling pathway	68/1161	279/7206	0.00032401278929
ko04141	Protein processing in endoplasmic reticulum	13/1161	184/7206	0.000335593527261
ko04924	Renin secretion	27/1161	86/7206	0.000337103792066
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1161	79/7206	0.00054611626698
ko05169	Epstein-Barr virus infection	17/1161	206/7206	0.00103511236849
ko04966	Collecting duct acid secretion	11/1161	26/7206	0.00133815991575
ko05414	Dilated cardiomyopathy	31/1161	112/7206	0.00168364524626
ko04260	Cardiac muscle contraction	28/1161	98/7206	0.00199509118085
ko05162	Measles	8/1161	120/7206	0.00254566426648
ko04923	Regulation of lipolysis in adipocytes	23/1161	77/7206	0.00255143499222
ko04110	Cell cycle	11/1161	145/7206	0.00292359198851
ko00240	Pyrimidine metabolism	7/1161	110/7206	0.00364542038411
ko00620	Pyruvate metabolism	1/1161	46/7206	0.00448154364375
ko03420	Nucleotide excision repair	1/1161	46/7206	0.00448154364375
ko04930	Type II diabetes mellitus	17/1161	54/7206	0.00449366246004
ko00260	Glycine, serine and threonine metabolism	1/1161	48/7206	0.00466220349978
ko04064	NF-kappa B signaling pathway	6/1161	96/7206	0.0050246166888
ko04657	IL-17 signaling pathway	5/1161	87/7206	0.0050329582267
ko05133	Pertussis	5/1161	87/7206	0.0050329582267
ko05110	Vibrio cholerae infection	19/1161	63/7206	0.00503529836548
ko04146	Peroxisome	5/1161	89/7206	0.00520363878647
ko05231	Choline metabolism in cancer	34/1161	134/7206	0.00592603004797
ko04710	Circadian rhythm	14/1161	43/7206	0.00627494637778
ko03022	Basal transcription factors	1/1161	44/7206	0.0066992139952
ko04120	Ubiquitin mediated proteolysis	11/1161	138/7206	0.0068284752146
ko00071	Fatty acid degradation	1/1161	45/7206	0.00684600444119
ko04915	Estrogen signaling pathway	33/1161	131/7206	0.00778600716047
ko04976	Bile secretion	22/1161	80/7206	0.00871141761365
ko05131	Shigellosis	5/1161	82/7206	0.00971463157306
ko04214	Apoptosis - fly	4/1161	72/7206	0.00971987294318
ko00310	Lysine degradation	4/1161	73/7206	0.00973694170402
ko04115	p53 signaling pathway	4/1161	74/7206	0.00994863664761
ko04711	Circadian rhythm - fly	6/1161	13/7206	0.0106619061177
ko05205	Proteoglycans in cancer	29/1161	271/7206	0.0114885364801
ko00590	Arachidonic acid metabolism	2/1161	52/7206	0.0123974170642
ko04371	Apelin signaling pathway	41/1161	177/7206	0.0127377631394
ko04217	Necroptosis	17/1161	178/7206	0.0131802762517
ko00330	Arginine and proline metabolism	3/1161	61/7206	0.0133325250556
ko04610	Complement and coagulation cascades	5/1161	79/7206	0.0134110794975
ko04622	RIG-I-like receptor signaling pathway	3/1161	62/7206	0.0136662648981
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1161	14/7206	0.0161557736232
ko04658	Th1 and Th2 cell differentiation	7/1161	96/7206	0.0166364749924
ko05219	Bladder cancer	2/1161	48/7206	0.0177323602575
ko04142	Lysosome	14/1161	151/7206	0.0185707236338
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1161	182/7206	0.0186609310639
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1161	100/7206	0.0194637656329
ko04071	Sphingolipid signaling pathway	37/1161	162/7206	0.0228673654511
ko03410	Base excision repair	1/1161	38/7206	0.0236108429126
ko03018	RNA degradation	6/1161	84/7206	0.0240065078268
ko04912	GnRH signaling pathway	29/1161	122/7206	0.0250264562064
ko04510	Focal adhesion	26/1161	240/7206	0.0251261971113
ko05140	Leishmaniasis	5/1161	75/7206	0.0256373740319
ko04640	Hematopoietic cell lineage	4/1161	64/7206	0.0263540582711
ko00480	Glutathione metabolism	3/1161	55/7206	0.026631560997
ko04722	Neurotrophin signaling pathway	36/1161	160/7206	0.0296841809026
ko05016	Huntington's disease	23/1161	215/7206	0.0298033038189
ko04015	Rap1 signaling pathway	58/1161	278/7206	0.0305845912017
ko04960	Aldosterone-regulated sodium reabsorption	12/1161	41/7206	0.0309498502347
ko00640	Propanoate metabolism	1/1161	34/7206	0.0334162288508
ko00860	Porphyrin and chlorophyll metabolism	1/1161	34/7206	0.0334162288508
ko04975	Fat digestion and absorption	1/1161	35/7206	0.0343875326232
ko04973	Carbohydrate digestion and absorption	12/1161	42/7206	0.03493851269
ko05215	Prostate cancer	10/1161	111/7206	0.0375089207335
ko01200	Carbon metabolism	12/1161	128/7206	0.0383841239226
ko00280	Valine, leucine and isoleucine degradation	3/1161	54/7206	0.0384513507262
ko05144	Malaria	2/1161	45/7206	0.0386138262596
ko04918	Thyroid hormone synthesis	21/1161	86/7206	0.0392859778919
ko04964	Proximal tubule bicarbonate reclamation	9/1161	29/7206	0.0398118814118
ko00562	Inositol phosphate metabolism	22/1161	89/7206	0.0405405341575
ko04140	Autophagy - animal	17/1161	164/7206	0.0412883125141
ko05202	Transcriptional misregulation in cancer	20/1161	188/7206	0.0436453067985
ko04113	Meiosis - yeast	5/1161	70/7206	0.0478062618779