ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 23/188 191/7206 6.31156388226e-10 ko04621 NOD-like receptor signaling pathway 19/188 157/7206 1.98710652794e-08 ko05164 Influenza A 19/188 167/7206 5.48777334536e-08 ko04064 NF-kappa B signaling pathway 14/188 96/7206 1.53287032143e-07 ko04380 Osteoclast differentiation 16/188 134/7206 3.34034370731e-07 ko04217 Necroptosis 18/188 178/7206 7.47372875587e-07 ko04622 RIG-I-like receptor signaling pathway 10/188 62/7206 3.80603808971e-06 ko05145 Toxoplasmosis 14/188 126/7206 4.44608788496e-06 ko04658 Th1 and Th2 cell differentiation 12/188 96/7206 6.44188967674e-06 ko05340 Primary immunodeficiency 7/188 30/7206 9.00678752608e-06 ko05162 Measles 13/188 120/7206 1.30376042014e-05 ko04668 TNF signaling pathway 13/188 120/7206 1.30376042014e-05 ko05168 Herpes simplex infection 16/188 182/7206 1.92438638899e-05 ko05140 Leishmaniasis 10/188 75/7206 2.18651538712e-05 ko04672 Intestinal immune network for IgA production 7/188 37/7206 3.90217759515e-05 ko05161 Hepatitis B 15/188 173/7206 4.15628530199e-05 ko05152 Tuberculosis 15/188 187/7206 0.000101734322527 ko05167 Kaposi's sarcoma-associated herpesvirus infection 15/188 191/7206 0.000129125227838 ko00120 Primary bile acid biosynthesis 5/188 20/7206 0.000129164041299 ko04612 Antigen processing and presentation 9/188 77/7206 0.000161399671633 ko05160 Hepatitis C 13/188 153/7206 0.000167858976457 ko04620 Toll-like receptor signaling pathway 10/188 100/7206 0.000259677031984 ko05133 Pertussis 9/188 87/7206 0.000410164391467 ko04659 Th17 cell differentiation 10/188 106/7206 0.000417433076071 ko05321 Inflammatory bowel disease (IBD) 7/188 56/7206 0.000578582025703 ko04623 Cytosolic DNA-sensing pathway 6/188 41/7206 0.000611903932856 ko04630 Jak-STAT signaling pathway 11/188 132/7206 0.000630727857717 ko04080 Neuroactive ligand-receptor interaction 2/188 423/7206 0.00144534003584 ko00350 Tyrosine metabolism 5/188 33/7206 0.00150167491281 ko05323 Rheumatoid arthritis 8/188 89/7206 0.00214895287272 ko04210 Apoptosis 12/188 180/7206 0.00254085606033 ko04650 Natural killer cell mediated cytotoxicity 8/188 97/7206 0.00368583884052 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/188 4/7206 0.00392425695971 ko00643 Styrene degradation 2/188 4/7206 0.00392425695971 ko00140 Steroid hormone biosynthesis 5/188 41/7206 0.00400731089391 ko04660 T cell receptor signaling pathway 9/188 124/7206 0.00497297602572 ko04062 Chemokine signaling pathway 12/188 201/7206 0.00618564222409 ko05142 Chagas disease (American trypanosomiasis) 9/188 130/7206 0.0067545717571 ko04662 B cell receptor signaling pathway 7/188 88/7206 0.00787772185007 ko00360 Phenylalanine metabolism 3/188 17/7206 0.00907416845194 ko00590 Arachidonic acid metabolism 5/188 52/7206 0.0110425994069 ko05150 Staphylococcus aureus infection 4/188 36/7206 0.0137727705277 ko00100 Steroid biosynthesis 3/188 21/7206 0.0164444277514 ko04610 Complement and coagulation cascades 6/188 79/7206 0.0167576146872 ko00051 Fructose and mannose metabolism 4/188 42/7206 0.0232039125384 ko05330 Allograft rejection 3/188 24/7206 0.0236399428177 ko05215 Prostate cancer 7/188 111/7206 0.025651201426 ko04917 Prolactin signaling pathway 6/188 87/7206 0.0257000022613 ko04657 IL-17 signaling pathway 6/188 87/7206 0.0257000022613 ko00401 Novobiocin biosynthesis 1/188 1/7206 0.0260893699695 ko00950 Isoquinoline alkaloid biosynthesis 2/188 10/7206 0.0265465459094 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 2/188 11/7206 0.0318967529111 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/188 92/7206 0.032657144829 ko04215 Apoptosis - multiple species 4/188 47/7206 0.0334663745902 ko03320 PPAR signaling pathway 5/188 69/7206 0.0335822836198 ko04145 Phagosome 9/188 162/7206 0.038715797696 ko05320 Autoimmune thyroid disease 3/188 29/7206 0.0388340573597 ko05132 Salmonella infection 6/188 98/7206 0.0424935335771 ko05134 Legionellosis 5/188 74/7206 0.0434372793369 ko04115 p53 signaling pathway 5/188 74/7206 0.0434372793369 ko05146 Amoebiasis 6/188 99/7206 0.0442957258819 ko01524 Platinum drug resistance 5/188 76/7206 0.0478176886995