ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1225	423/7206	2.5831615223e-54
ko04724	Glutamatergic synapse	92/1225	152/7206	3.5507216763e-34
ko05033	Nicotine addiction	49/1225	56/7206	5.91030675298e-31
ko05032	Morphine addiction	69/1225	110/7206	3.41987456499e-27
ko04713	Circadian entrainment	77/1225	136/7206	4.67833070554e-26
ko04721	Synaptic vesicle cycle	56/1225	80/7206	6.71003823026e-26
ko04727	GABAergic synapse	67/1225	110/7206	2.36405614582e-25
ko04728	Dopaminergic synapse	87/1225	185/7206	7.3927215897e-22
ko04725	Cholinergic synapse	77/1225	160/7206	3.21769363246e-20
ko04024	cAMP signaling pathway	108/1225	279/7206	1.22445003648e-18
ko04020	Calcium signaling pathway	104/1225	265/7206	1.51676108694e-18
ko04723	Retrograde endocannabinoid signaling	78/1225	175/7206	5.67680728545e-18
ko04911	Insulin secretion	60/1225	117/7206	1.06994502572e-17
ko04742	Taste transduction	39/1225	61/7206	2.69361758111e-16
ko04921	Oxytocin signaling pathway	79/1225	209/7206	3.41103908069e-13
ko04726	Serotonergic synapse	59/1225	137/7206	4.41814950615e-13
ko05031	Amphetamine addiction	45/1225	91/7206	7.45506792276e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1225	205/7206	9.22791337742e-13
ko04744	Phototransduction	25/1225	36/7206	4.11861536681e-12
ko04720	Long-term potentiation	46/1225	99/7206	6.92954139022e-12
ko04360	Axon guidance	82/1225	233/7206	8.51398541275e-12
ko04970	Salivary secretion	44/1225	95/7206	2.28541140787e-11
ko03040	Spliceosome	1/1225	145/7206	7.10929870572e-11
ko05168	Herpes simplex infection	6/1225	182/7206	1.00139902591e-08
ko05030	Cocaine addiction	33/1225	73/7206	1.56980491974e-08
ko04740	Olfactory transduction	35/1225	80/7206	1.64380118615e-08
ko05203	Viral carcinogenesis	16/1225	277/7206	1.92561482454e-08
ko04971	Gastric acid secretion	39/1225	98/7206	7.08257006302e-08
ko04925	Aldosterone synthesis and secretion	40/1225	105/7206	2.30538694465e-07
ko04060	Cytokine-cytokine receptor interaction	9/1225	191/7206	2.59935179111e-07
ko04966	Collecting duct acid secretion	16/1225	26/7206	4.27220989405e-07
ko03013	RNA transport	7/1225	166/7206	5.69599636472e-07
ko05164	Influenza A	7/1225	167/7206	5.80217897133e-07
ko04022	cGMP-PKG signaling pathway	66/1225	216/7206	7.36052595794e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1225	74/7206	1.27545055846e-06
ko04924	Renin secretion	33/1225	86/7206	1.76515647706e-06
ko04010	MAPK signaling pathway	87/1225	321/7206	3.0663188879e-06
ko05110	Vibrio cholerae infection	26/1225	63/7206	4.37233324411e-06
ko04972	Pancreatic secretion	38/1225	111/7206	9.13172564777e-06
ko04120	Ubiquitin mediated proteolysis	6/1225	138/7206	9.35626496857e-06
ko04141	Protein processing in endoplasmic reticulum	11/1225	184/7206	9.8178966144e-06
ko04540	Gap junction	42/1225	128/7206	1.25588519422e-05
ko04745	Phototransduction - fly	18/1225	38/7206	1.35186049894e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1225	59/7206	1.3655766802e-05
ko04260	Cardiac muscle contraction	34/1225	98/7206	1.78330825606e-05
ko05205	Proteoglycans in cancer	22/1225	271/7206	2.30705546475e-05
ko05322	Systemic lupus erythematosus	8/1225	151/7206	2.38265857783e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1225	79/7206	6.20282017095e-05
ko05169	Epstein-Barr virus infection	15/1225	206/7206	6.4890897903e-05
ko04514	Cell adhesion molecules (CAMs)	40/1225	130/7206	8.46983215994e-05
ko04621	NOD-like receptor signaling pathway	10/1225	157/7206	9.72406527893e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1225	79/7206	0.000111156902781
ko05140	Leishmaniasis	2/1225	75/7206	0.00016196466991
ko04064	NF-kappa B signaling pathway	4/1225	96/7206	0.000182411373791
ko04730	Long-term depression	27/1225	78/7206	0.000184887056861
ko05414	Dilated cardiomyopathy	35/1225	112/7206	0.000186308102341
ko04070	Phosphatidylinositol signaling system	35/1225	112/7206	0.000186308102341
ko04014	Ras signaling pathway	70/1225	279/7206	0.000448792451467
ko04110	Cell cycle	10/1225	145/7206	0.000478763449848
ko05162	Measles	7/1225	120/7206	0.000499460894322
ko04146	Peroxisome	4/1225	89/7206	0.000549992416849
ko04976	Bile secretion	26/1225	80/7206	0.000766511059774
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1225	14/7206	0.000777968021727
ko00480	Glutathione metabolism	1/1225	55/7206	0.000846916142302
ko05161	Hepatitis B	14/1225	173/7206	0.000954851263432
ko04640	Hematopoietic cell lineage	2/1225	64/7206	0.00118446585547
ko00590	Arachidonic acid metabolism	1/1225	52/7206	0.00125150228641
ko00240	Pyrimidine metabolism	7/1225	110/7206	0.00130342744568
ko04750	Inflammatory mediator regulation of TRP channels	35/1225	122/7206	0.0013753854352
ko04072	Phospholipase D signaling pathway	51/1225	197/7206	0.00140621961132
ko04915	Estrogen signaling pathway	36/1225	131/7206	0.00217271044629
ko04630	Jak-STAT signaling pathway	10/1225	132/7206	0.00221187205717
ko03420	Nucleotide excision repair	1/1225	46/7206	0.00284833802519
ko00260	Glycine, serine and threonine metabolism	1/1225	48/7206	0.00296598921534
ko01524	Platinum drug resistance	4/1225	76/7206	0.00330530160846
ko04612	Antigen processing and presentation	4/1225	77/7206	0.00332464081322
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1225	182/7206	0.00368355158722
ko05321	Inflammatory bowel disease (IBD)	2/1225	56/7206	0.00375460473273
ko03022	Basal transcription factors	1/1225	44/7206	0.00427038825767
ko05144	Malaria	1/1225	45/7206	0.00434417527943
ko00071	Fatty acid degradation	1/1225	45/7206	0.00434417527943
ko04620	Toll-like receptor signaling pathway	7/1225	100/7206	0.00468835520974
ko03018	RNA degradation	5/1225	84/7206	0.00491991379637
ko05145	Toxoplasmosis	10/1225	126/7206	0.00548977035442
ko04964	Proximal tubule bicarbonate reclamation	11/1225	29/7206	0.00575943891826
ko04140	Autophagy - animal	15/1225	164/7206	0.0059310264821
ko04626	Plant-pathogen interaction	8/1225	18/7206	0.00598217686035
ko04622	RIG-I-like receptor signaling pathway	3/1225	62/7206	0.00626391694121
ko04214	Apoptosis - fly	4/1225	72/7206	0.00667837664343
ko04210	Apoptosis	18/1225	180/7206	0.00894197365381
ko00330	Arginine and proline metabolism	3/1225	61/7206	0.00914794895202
ko04657	IL-17 signaling pathway	6/1225	87/7206	0.00915074075261
ko05133	Pertussis	6/1225	87/7206	0.00915074075261
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1225	40/7206	0.00978223000935
ko04371	Apelin signaling pathway	43/1225	177/7206	0.0112200593086
ko04918	Thyroid hormone synthesis	24/1225	86/7206	0.0130319928095
ko04923	Regulation of lipolysis in adipocytes	22/1225	77/7206	0.0134798127378
ko04015	Rap1 signaling pathway	63/1225	278/7206	0.0142695683718
ko00982	Drug metabolism - cytochrome P450	1/1225	37/7206	0.014509641702
ko00630	Glyoxylate and dicarboxylate metabolism	1/1225	38/7206	0.0149263140066
ko05131	Shigellosis	6/1225	82/7206	0.0171168231593
ko00620	Pyruvate metabolism	2/1225	46/7206	0.0171552957884
ko00270	Cysteine and methionine metabolism	2/1225	47/7206	0.0175051115087
ko00310	Lysine degradation	5/1225	73/7206	0.0179340801585
ko05418	Fluid shear stress and atherosclerosis	18/1225	173/7206	0.0181352663266
ko04115	p53 signaling pathway	5/1225	74/7206	0.0183009012092
ko04658	Th1 and Th2 cell differentiation	8/1225	96/7206	0.0197631702548
ko05215	Prostate cancer	10/1225	111/7206	0.0215523603622
ko00640	Propanoate metabolism	1/1225	34/7206	0.021723494424
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1225	100/7206	0.0218369008774
ko05222	Small cell lung cancer	7/1225	89/7206	0.0219061647149
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1225	92/7206	0.0248909329381
ko04912	GnRH signaling pathway	30/1225	122/7206	0.0285637030182
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1225	26/7206	0.0307600885383
ko05166	HTLV-I infection	36/1225	292/7206	0.0314418863681
ko04916	Melanogenesis	34/1225	142/7206	0.031590616196
ko03320	PPAR signaling pathway	5/1225	69/7206	0.0344307864973
ko05034	Alcoholism	53/1225	238/7206	0.0347071454873
ko00140	Steroid hormone biosynthesis	2/1225	41/7206	0.03598941522
ko00380	Tryptophan metabolism	3/1225	50/7206	0.0365788467972
ko00983	Drug metabolism - other enzymes	2/1225	42/7206	0.036673204808
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1225	135/7206	0.0372151122709
ko04668	TNF signaling pathway	12/1225	120/7206	0.0373061791356
ko05212	Pancreatic cancer	7/1225	83/7206	0.0384929023023
ko04270	Vascular smooth muscle contraction	36/1225	154/7206	0.0389499720421
ko05206	MicroRNAs in cancer	20/1225	177/7206	0.0423337541329
ko01200	Carbon metabolism	13/1225	128/7206	0.0425473357444
ko04510	Focal adhesion	29/1225	240/7206	0.0438802406454
ko04350	TGF-beta signaling pathway	10/1225	103/7206	0.0472782541325
ko05320	Autoimmune thyroid disease	1/1225	29/7206	0.0483656276912