ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1051	423/7206	3.58390775405e-46
ko04724	Glutamatergic synapse	83/1051	152/7206	2.06518478556e-31
ko05033	Nicotine addiction	47/1051	56/7206	4.14452525437e-31
ko05032	Morphine addiction	67/1051	110/7206	2.03146496697e-29
ko04727	GABAergic synapse	65/1051	110/7206	1.76077049822e-27
ko04728	Dopaminergic synapse	77/1051	185/7206	1.1259865763e-19
ko04723	Retrograde endocannabinoid signaling	74/1051	175/7206	1.99776677961e-19
ko04713	Circadian entrainment	63/1051	136/7206	3.79688605148e-19
ko04725	Cholinergic synapse	69/1051	160/7206	9.57333205268e-19
ko04721	Synaptic vesicle cycle	45/1051	80/7206	3.41925020341e-18
ko04024	cAMP signaling pathway	95/1051	279/7206	1.04433078972e-16
ko04742	Taste transduction	36/1051	61/7206	1.0245678081e-15
ko04911	Insulin secretion	50/1051	117/7206	1.01577534812e-13
ko04726	Serotonergic synapse	54/1051	137/7206	5.66886596648e-13
ko04020	Calcium signaling pathway	82/1051	265/7206	4.29194690276e-12
ko04261	Adrenergic signaling in cardiomyocytes	66/1051	205/7206	1.22730793698e-10
ko04921	Oxytocin signaling pathway	66/1051	209/7206	2.1981375592e-10
ko04360	Axon guidance	70/1051	233/7206	1.07417542797e-09
ko03040	Spliceosome	1/1051	145/7206	3.56836183378e-09
ko05203	Viral carcinogenesis	11/1051	277/7206	9.27594312731e-09
ko04744	Phototransduction	20/1051	36/7206	1.13647546063e-08
ko05031	Amphetamine addiction	34/1051	91/7206	5.74051620285e-08
ko05030	Cocaine addiction	29/1051	73/7206	1.15487607386e-07
ko04720	Long-term potentiation	35/1051	99/7206	1.81673448855e-07
ko04010	MAPK signaling pathway	81/1051	321/7206	2.60388692988e-07
ko05168	Herpes simplex infection	6/1051	182/7206	6.36761887933e-07
ko03013	RNA transport	5/1051	166/7206	1.06121692046e-06
ko04970	Salivary secretion	32/1051	95/7206	2.35328240617e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1051	79/7206	2.89060434382e-06
ko05322	Systemic lupus erythematosus	5/1051	151/7206	6.84075109976e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1051	74/7206	7.81997815686e-06
ko04141	Protein processing in endoplasmic reticulum	8/1051	184/7206	1.06383435631e-05
ko04971	Gastric acid secretion	31/1051	98/7206	1.60410509185e-05
ko05164	Influenza A	7/1051	167/7206	1.91443988296e-05
ko04972	Pancreatic secretion	33/1051	111/7206	3.34804193698e-05
ko05414	Dilated cardiomyopathy	33/1051	112/7206	3.93804823063e-05
ko04120	Ubiquitin mediated proteolysis	5/1051	138/7206	4.30359867541e-05
ko04022	cGMP-PKG signaling pathway	54/1051	216/7206	4.8658284199e-05
ko04060	Cytokine-cytokine receptor interaction	10/1051	191/7206	6.35276847341e-05
ko04925	Aldosterone synthesis and secretion	31/1051	105/7206	6.87266416205e-05
ko04514	Cell adhesion molecules (CAMs)	36/1051	130/7206	8.15814159772e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1051	79/7206	8.26517757003e-05
ko04260	Cardiac muscle contraction	29/1051	98/7206	0.000123685795613
ko04621	NOD-like receptor signaling pathway	8/1051	157/7206	0.000218238768993
ko05169	Epstein-Barr virus infection	13/1051	206/7206	0.00027678281428
ko04540	Gap junction	34/1051	128/7206	0.000336794811252
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1051	59/7206	0.000555119716397
ko04730	Long-term depression	23/1051	78/7206	0.000582289785825
ko05205	Proteoglycans in cancer	21/1051	271/7206	0.00079177337206
ko04612	Antigen processing and presentation	2/1051	77/7206	0.000931511565444
ko04072	Phospholipase D signaling pathway	46/1051	197/7206	0.000953538838609
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1051	182/7206	0.0012808289226
ko05140	Leishmaniasis	2/1051	75/7206	0.00140310867598
ko00240	Pyrimidine metabolism	5/1051	110/7206	0.00147820927241
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1051	14/7206	0.00184491386478
ko04064	NF-kappa B signaling pathway	4/1051	96/7206	0.0019061099954
ko04014	Ras signaling pathway	59/1051	279/7206	0.00238502016461
ko04966	Collecting duct acid secretion	10/1051	26/7206	0.0023912932464
ko05161	Hepatitis B	12/1051	173/7206	0.00299343618604
ko00520	Amino sugar and nucleotide sugar metabolism	1/1051	55/7206	0.00326568133413
ko00480	Glutathione metabolism	1/1051	55/7206	0.00326568133413
ko04146	Peroxisome	4/1051	89/7206	0.00373904215221
ko00590	Arachidonic acid metabolism	1/1051	52/7206	0.00485306093472
ko05133	Pertussis	4/1051	87/7206	0.00532697243945
ko04110	Cell cycle	10/1051	145/7206	0.00596033851791
ko04740	Olfactory transduction	21/1051	80/7206	0.0059820985031
ko04976	Bile secretion	21/1051	80/7206	0.0059820985031
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1051	100/7206	0.00603031616091
ko04640	Hematopoietic cell lineage	2/1051	64/7206	0.00646859026116
ko05145	Toxoplasmosis	8/1051	126/7206	0.00693454603539
ko04214	Apoptosis - fly	3/1051	72/7206	0.00699475591239
ko03018	RNA degradation	4/1051	84/7206	0.00746306732919
ko04924	Renin secretion	22/1051	86/7206	0.00799518876157
ko04630	Jak-STAT signaling pathway	9/1051	132/7206	0.0085237915805
ko00330	Arginine and proline metabolism	2/1051	61/7206	0.00932347173457
ko04217	Necroptosis	14/1051	178/7206	0.00940570498483
ko05110	Vibrio cholerae infection	17/1051	63/7206	0.0105201996134
ko00620	Pyruvate metabolism	1/1051	46/7206	0.0107084181195
ko03420	Nucleotide excision repair	1/1051	46/7206	0.0107084181195
ko01200	Carbon metabolism	9/1051	128/7206	0.011273604002
ko04915	Estrogen signaling pathway	30/1051	131/7206	0.0117223656431
ko05162	Measles	8/1051	120/7206	0.0124115640053
ko05321	Inflammatory bowel disease (IBD)	2/1051	56/7206	0.0129612898699
ko04140	Autophagy - animal	13/1051	164/7206	0.0133146587222
ko04070	Phosphatidylinositol signaling system	26/1051	112/7206	0.0143004999968
ko03022	Basal transcription factors	1/1051	44/7206	0.0162183933626
ko05144	Malaria	1/1051	45/7206	0.0169691351356
ko00071	Fatty acid degradation	1/1051	45/7206	0.0169691351356
ko04658	Th1 and Th2 cell differentiation	6/1051	96/7206	0.0187691694419
ko00280	Valine, leucine and isoleucine degradation	2/1051	54/7206	0.0187998517214
ko04670	Leukocyte transendothelial migration	12/1051	151/7206	0.0191019163242
ko01524	Platinum drug resistance	4/1051	76/7206	0.0205542275905
ko00515	Mannose type O-glycan biosynthesis	8/1051	25/7206	0.0216039037803
ko04371	Apelin signaling pathway	37/1051	177/7206	0.0228314661168
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1051	40/7206	0.0235517980578
ko04391	Hippo signaling pathway - fly	21/1051	90/7206	0.0235751205405
ko04015	Rap1 signaling pathway	54/1051	278/7206	0.0239547917977
ko00983	Drug metabolism - other enzymes	1/1051	42/7206	0.0248989731456
ko05131	Shigellosis	5/1051	82/7206	0.026603271355
ko04137	Mitophagy - animal	5/1051	82/7206	0.026603271355
ko00380	Tryptophan metabolism	2/1051	50/7206	0.0269426996332
ko04622	RIG-I-like receptor signaling pathway	3/1051	62/7206	0.0282945616185
ko05418	Fluid shear stress and atherosclerosis	15/1051	173/7206	0.0284013085327
ko05215	Prostate cancer	8/1051	111/7206	0.0288601551288
ko04964	Proximal tubule bicarbonate reclamation	9/1051	29/7206	0.0288768313425
ko04916	Melanogenesis	30/1051	142/7206	0.0304186105326
ko05146	Amoebiasis	7/1051	99/7206	0.0309287320911
ko04620	Toll-like receptor signaling pathway	7/1051	100/7206	0.0311749331349
ko04218	Cellular senescence	16/1051	177/7206	0.0312040252657
ko04923	Regulation of lipolysis in adipocytes	18/1051	77/7206	0.0343576431764
ko00982	Drug metabolism - cytochrome P450	1/1051	37/7206	0.0348532257932
ko04142	Lysosome	13/1051	151/7206	0.0354309463181
ko04750	Inflammatory mediator regulation of TRP channels	26/1051	122/7206	0.0384304079055
ko00270	Cysteine and methionine metabolism	2/1051	47/7206	0.0386436558338
ko05219	Bladder cancer	2/1051	48/7206	0.0386747604014
ko04510	Focal adhesion	24/1051	240/7206	0.0405364712358
ko04657	IL-17 signaling pathway	6/1051	87/7206	0.0453257683623
ko04350	TGF-beta signaling pathway	8/1051	103/7206	0.0485669795738