ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1272	423/7206	1.91494025265e-56
ko04724	Glutamatergic synapse	95/1272	152/7206	1.59899091749e-35
ko05033	Nicotine addiction	51/1272	56/7206	2.54985101703e-33
ko05032	Morphine addiction	73/1272	110/7206	5.65887838289e-30
ko04713	Circadian entrainment	82/1272	136/7206	3.6234977145e-29
ko04727	GABAergic synapse	72/1272	110/7206	5.36755886457e-29
ko04725	Cholinergic synapse	82/1272	160/7206	1.2147561238e-22
ko04728	Dopaminergic synapse	89/1272	185/7206	5.05056772678e-22
ko04721	Synaptic vesicle cycle	52/1272	80/7206	4.89513141446e-21
ko04723	Retrograde endocannabinoid signaling	83/1272	175/7206	4.18756361791e-20
ko04024	cAMP signaling pathway	111/1272	279/7206	5.29443916048e-19
ko04020	Calcium signaling pathway	105/1272	265/7206	7.27837303022e-18
ko04911	Insulin secretion	59/1272	117/7206	3.51957885866e-16
ko04726	Serotonergic synapse	65/1272	137/7206	5.36396136786e-16
ko04742	Taste transduction	38/1272	61/7206	8.29407159791e-15
ko04744	Phototransduction	26/1272	36/7206	8.63255941509e-13
ko04921	Oxytocin signaling pathway	80/1272	209/7206	8.73041388499e-13
ko05031	Amphetamine addiction	45/1272	91/7206	2.94040684502e-12
ko04970	Salivary secretion	45/1272	95/7206	1.94996227848e-11
ko04720	Long-term potentiation	46/1272	99/7206	2.69322683872e-11
ko04740	Olfactory transduction	39/1272	80/7206	1.46597715011e-10
ko03040	Spliceosome	2/1272	145/7206	3.64558378308e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1272	205/7206	5.69445647401e-10
ko04925	Aldosterone synthesis and secretion	44/1272	105/7206	5.44094945375e-09
ko05030	Cocaine addiction	33/1272	73/7206	4.08462915623e-08
ko04971	Gastric acid secretion	40/1272	98/7206	5.69618345303e-08
ko05168	Herpes simplex infection	9/1272	182/7206	3.39404941423e-07
ko05322	Systemic lupus erythematosus	6/1272	151/7206	4.2545514326e-07
ko04022	cGMP-PKG signaling pathway	68/1272	216/7206	4.56404070052e-07
ko03013	RNA transport	8/1272	166/7206	8.84894189543e-07
ko04360	Axon guidance	70/1272	233/7206	2.76650343775e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1272	74/7206	3.40321551925e-06
ko04621	NOD-like receptor signaling pathway	8/1272	157/7206	3.75722450225e-06
ko04966	Collecting duct acid secretion	15/1272	26/7206	5.1098065124e-06
ko04972	Pancreatic secretion	39/1272	111/7206	7.69102312639e-06
ko05203	Viral carcinogenesis	23/1272	277/7206	8.5052294112e-06
ko04540	Gap junction	43/1272	128/7206	1.0639019457e-05
ko04070	Phosphatidylinositol signaling system	39/1272	112/7206	1.35847932038e-05
ko04730	Long-term depression	30/1272	78/7206	1.45001996382e-05
ko04010	MAPK signaling pathway	87/1272	321/7206	1.71662337028e-05
ko04060	Cytokine-cytokine receptor interaction	13/1272	191/7206	1.83113722691e-05
ko04110	Cell cycle	8/1272	145/7206	2.20649378144e-05
ko04745	Phototransduction - fly	18/1272	38/7206	2.31144680096e-05
ko04072	Phospholipase D signaling pathway	58/1272	197/7206	3.82273326553e-05
ko04141	Protein processing in endoplasmic reticulum	13/1272	184/7206	4.82284001362e-05
ko05164	Influenza A	11/1272	167/7206	4.94633962e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1272	122/7206	5.66381319725e-05
ko04120	Ubiquitin mediated proteolysis	8/1272	138/7206	6.26807260263e-05
ko04612	Antigen processing and presentation	2/1272	77/7206	6.84111215032e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1272	79/7206	7.22297608911e-05
ko05414	Dilated cardiomyopathy	37/1272	112/7206	7.90457051107e-05
ko04514	Cell adhesion molecules (CAMs)	41/1272	130/7206	0.00010144160571
ko04923	Regulation of lipolysis in adipocytes	28/1272	77/7206	0.00011122165753
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1272	79/7206	0.000142724223579
ko04014	Ras signaling pathway	74/1272	279/7206	0.000155454422825
ko04976	Bile secretion	28/1272	80/7206	0.00016893534601
ko04915	Estrogen signaling pathway	40/1272	131/7206	0.00028166318737
ko05110	Vibrio cholerae infection	23/1272	63/7206	0.000336989471777
ko05140	Leishmaniasis	3/1272	75/7206	0.000652166301422
ko05169	Epstein-Barr virus infection	19/1272	206/7206	0.000785491564568
ko04924	Renin secretion	28/1272	86/7206	0.000854802453613
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1272	59/7206	0.000865767034327
ko04064	NF-kappa B signaling pathway	6/1272	96/7206	0.0017295675833
ko04371	Apelin signaling pathway	48/1272	177/7206	0.00182224365267
ko04260	Cardiac muscle contraction	30/1272	98/7206	0.00185542117533
ko04710	Circadian rhythm	16/1272	43/7206	0.00201915921224
ko05162	Measles	9/1272	120/7206	0.00228877691146
ko04964	Proximal tubule bicarbonate reclamation	12/1272	29/7206	0.00234096748442
ko00071	Fatty acid degradation	1/1272	45/7206	0.00273289927532
ko03420	Nucleotide excision repair	1/1272	46/7206	0.00281650723258
ko05131	Shigellosis	5/1272	82/7206	0.00332555039651
ko04918	Thyroid hormone synthesis	26/1272	86/7206	0.00399167933097
ko04622	RIG-I-like receptor signaling pathway	3/1272	62/7206	0.0042208000002
ko03022	Basal transcription factors	1/1272	44/7206	0.00434384658634
ko04214	Apoptosis - fly	4/1272	72/7206	0.00459005421361
ko05161	Hepatitis B	17/1272	173/7206	0.0046068048372
ko04146	Peroxisome	6/1272	89/7206	0.00469080421314
ko04270	Vascular smooth muscle contraction	41/1272	154/7206	0.00517955911338
ko00590	Arachidonic acid metabolism	2/1272	52/7206	0.00537519464406
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1272	14/7206	0.00568177758333
ko04930	Type II diabetes mellitus	18/1272	54/7206	0.00602764733656
ko05145	Toxoplasmosis	11/1272	126/7206	0.00637463837308
ko04658	Th1 and Th2 cell differentiation	7/1272	96/7206	0.00642010759842
ko04657	IL-17 signaling pathway	6/1272	87/7206	0.0065545676415
ko05133	Pertussis	6/1272	87/7206	0.0065545676415
ko04922	Glucagon signaling pathway	35/1272	128/7206	0.00667450162433
ko04973	Carbohydrate digestion and absorption	15/1272	42/7206	0.0067164982911
ko04626	Plant-pathogen interaction	8/1272	18/7206	0.00756919305872
ko00240	Pyrimidine metabolism	9/1272	110/7206	0.00758977949711
ko05205	Proteoglycans in cancer	32/1272	271/7206	0.00918580953078
ko00910	Nitrogen metabolism	8/1272	19/7206	0.0110847325684
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1272	100/7206	0.0112876625598
ko04960	Aldosterone-regulated sodium reabsorption	14/1272	41/7206	0.0115503922481
ko05219	Bladder cancer	2/1272	48/7206	0.0118706239981
ko05321	Inflammatory bowel disease (IBD)	3/1272	56/7206	0.0126051789166
ko00500	Starch and sucrose metabolism	1/1272	35/7206	0.0141713234898
ko04062	Chemokine signaling pathway	49/1272	201/7206	0.0144279788539
ko04630	Jak-STAT signaling pathway	13/1272	132/7206	0.0152987937398
ko04213	Longevity regulating pathway - multiple species	24/1272	86/7206	0.0155298862101
ko04912	GnRH signaling pathway	32/1272	122/7206	0.0161889637554
ko04610	Complement and coagulation cascades	6/1272	79/7206	0.0167122663106
ko05144	Malaria	2/1272	45/7206	0.0169321427201
ko00330	Arginine and proline metabolism	4/1272	61/7206	0.0179406315158
ko00280	Valine, leucine and isoleucine degradation	3/1272	54/7206	0.0181967452907
ko04916	Melanogenesis	36/1272	142/7206	0.0191967745802
ko05202	Transcriptional misregulation in cancer	21/1272	188/7206	0.0194907972797
ko03018	RNA degradation	7/1272	84/7206	0.0209919701123
ko00860	Porphyrin and chlorophyll metabolism	1/1272	34/7206	0.021596524135
ko04217	Necroptosis	20/1272	178/7206	0.0217927677978
ko05166	HTLV-I infection	37/1272	292/7206	0.0228180083538
ko04962	Vasopressin-regulated water reabsorption	17/1272	58/7206	0.0245053985192
ko00562	Inositol phosphate metabolism	24/1272	89/7206	0.0249928332931
ko05206	MicroRNAs in cancer	20/1272	177/7206	0.0274674046653
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1272	182/7206	0.0297699591404
ko04015	Rap1 signaling pathway	63/1272	278/7206	0.0300282561834
ko00310	Lysine degradation	6/1272	73/7206	0.0306050288411
ko04115	p53 signaling pathway	6/1272	74/7206	0.0307706868791
ko04114	Oocyte meiosis	34/1272	139/7206	0.042334783954
ko04330	Notch signaling pathway	5/1272	62/7206	0.0448432761617
ko00600	Sphingolipid metabolism	5/1272	63/7206	0.0450510145347
ko05016	Huntington's disease	27/1272	215/7206	0.0458395203221
ko05320	Autoimmune thyroid disease	1/1272	29/7206	0.0479170776046