ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 94/780 145/7206 2.57311376493e-56 ko04110 Cell cycle 65/780 145/7206 4.80163171906e-26 ko03013 RNA transport 70/780 166/7206 5.22376892867e-26 ko03440 Homologous recombination 32/780 41/7206 9.51930561121e-24 ko03460 Fanconi anemia pathway 35/780 51/7206 1.04541020311e-22 ko04111 Cell cycle - yeast 47/780 90/7206 1.17333812438e-22 ko03030 DNA replication 30/780 38/7206 1.35453067808e-22 ko05322 Systemic lupus erythematosus 62/780 151/7206 2.18825620638e-22 ko03008 Ribosome biogenesis in eukaryotes 37/780 79/7206 4.56056148623e-16 ko04113 Meiosis - yeast 34/780 70/7206 1.81020479628e-15 ko03430 Mismatch repair 18/780 22/7206 1.67112014183e-14 ko03420 Nucleotide excision repair 26/780 46/7206 3.58212502233e-14 ko05034 Alcoholism 66/780 238/7206 1.36172178484e-13 ko03022 Basal transcription factors 23/780 44/7206 9.94803162332e-12 ko05203 Viral carcinogenesis 69/780 277/7206 1.53600684323e-11 ko00240 Pyrimidine metabolism 38/780 110/7206 2.07229834829e-11 ko03018 RNA degradation 29/780 84/7206 5.21018259487e-09 ko03410 Base excision repair 18/780 38/7206 1.41641819474e-08 ko04024 cAMP signaling pathway 6/780 279/7206 3.55594105442e-08 ko04144 Endocytosis 10/780 342/7206 5.3516523685e-08 ko03015 mRNA surveillance pathway 29/780 93/7206 6.97868891534e-08 ko04060 Cytokine-cytokine receptor interaction 2/780 191/7206 1.67277732663e-07 ko04022 cGMP-PKG signaling pathway 4/780 216/7206 5.72265336626e-07 ko04270 Vascular smooth muscle contraction 1/780 154/7206 5.87388284314e-07 ko05010 Alzheimer's disease 4/780 202/7206 2.63638342747e-06 ko03020 RNA polymerase 13/780 29/7206 3.29660150102e-06 ko03450 Non-homologous end-joining 9/780 15/7206 5.3401381762e-06 ko04723 Retrograde endocannabinoid signaling 3/780 175/7206 5.74040609442e-06 ko04510 Focal adhesion 7/780 240/7206 6.69646120976e-06 ko04921 Oxytocin signaling pathway 5/780 209/7206 7.03929057383e-06 ko04724 Glutamatergic synapse 2/780 152/7206 8.11210075029e-06 ko04261 Adrenergic signaling in cardiomyocytes 5/780 205/7206 1.00366574796e-05 ko04514 Cell adhesion molecules (CAMs) 1/780 130/7206 1.04132128122e-05 ko00190 Oxidative phosphorylation 1/780 127/7206 1.60409782249e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/780 182/7206 1.62832353091e-05 ko04911 Insulin secretion 1/780 117/7206 3.356076466e-05 ko04151 PI3K-Akt signaling pathway 19/780 390/7206 3.43901451077e-05 ko05012 Parkinson's disease 3/780 155/7206 3.71177762982e-05 ko04713 Circadian entrainment 2/780 136/7206 3.79215999834e-05 ko04621 NOD-like receptor signaling pathway 3/780 157/7206 3.84963033792e-05 ko05152 Tuberculosis 5/780 187/7206 4.06467189167e-05 ko04010 MAPK signaling pathway 14/780 321/7206 4.37711477363e-05 ko04810 Regulation of actin cytoskeleton 10/780 264/7206 4.39495536924e-05 ko04015 Rap1 signaling pathway 11/780 278/7206 4.45479401343e-05 ko04142 Lysosome 3/780 151/7206 5.38226909616e-05 ko05414 Dilated cardiomyopathy 1/780 112/7206 7.86969509033e-05 ko01200 Carbon metabolism 2/780 128/7206 8.19554682054e-05 ko05205 Proteoglycans in cancer 11/780 271/7206 8.42526322962e-05 ko04014 Ras signaling pathway 12/780 279/7206 0.000110061205984 ko04725 Cholinergic synapse 4/780 160/7206 0.00014453872737 ko04750 Inflammatory mediator regulation of TRP channels 2/780 122/7206 0.000176582013927 ko04062 Chemokine signaling pathway 7/780 201/7206 0.000195140855821 ko04971 Gastric acid secretion 1/780 98/7206 0.000247189577876 ko05410 Hypertrophic cardiomyopathy (HCM) 1/780 100/7206 0.00025154504437 ko04728 Dopaminergic synapse 6/780 185/7206 0.000262098163039 ko04668 TNF signaling pathway 2/780 120/7206 0.00027043336581 ko04380 Osteoclast differentiation 3/780 134/7206 0.000347186517601 ko04974 Protein digestion and absorption 1/780 96/7206 0.000371240169363 ko04114 Oocyte meiosis 29/780 139/7206 0.000453460389969 ko04611 Platelet activation 5/780 163/7206 0.000470935573645 ko05142 Chagas disease (American trypanosomiasis) 3/780 130/7206 0.000496221990552 ko04915 Estrogen signaling pathway 3/780 131/7206 0.000510842298129 ko05031 Amphetamine addiction 1/780 91/7206 0.00054438708587 ko04727 GABAergic synapse 2/780 110/7206 0.000545513386543 ko05032 Morphine addiction 2/780 110/7206 0.000545513386543 ko04972 Pancreatic secretion 2/780 111/7206 0.000551241471797 ko04070 Phosphatidylinositol signaling system 2/780 112/7206 0.000564866661732 ko05145 Toxoplasmosis 3/780 126/7206 0.000708393179495 ko04659 Th17 cell differentiation 2/780 106/7206 0.000793347944072 ko00230 Purine metabolism 36/780 194/7206 0.000975762384573 ko04072 Phospholipase D signaling pathway 8/780 197/7206 0.000995058358163 ko04931 Insulin resistance 4/780 137/7206 0.00117775430115 ko04726 Serotonergic synapse 4/780 137/7206 0.00117775430115 ko04360 Axon guidance 11/780 233/7206 0.0012041715938 ko04924 Renin secretion 1/780 86/7206 0.00125148504419 ko04371 Apelin signaling pathway 7/780 177/7206 0.00133232159104 ko04530 Tight junction 11/780 228/7206 0.00160093305046 ko04630 Jak-STAT signaling pathway 4/780 132/7206 0.00162591205291 ko04620 Toll-like receptor signaling pathway 2/780 100/7206 0.00169860550443 ko04721 Synaptic vesicle cycle 1/780 80/7206 0.00177064463104 ko04914 Progesterone-mediated oocyte maturation 22/780 104/7206 0.00203109816389 ko04120 Ubiquitin mediated proteolysis 27/780 138/7206 0.00204983923692 ko04922 Glucagon signaling pathway 4/780 128/7206 0.00228025496382 ko04658 Th1 and Th2 cell differentiation 2/780 96/7206 0.00244751306392 ko05166 HTLV-I infection 48/780 292/7206 0.0027457856681 ko04218 Cellular senescence 32/780 177/7206 0.00308412833748 ko05030 Cocaine addiction 1/780 73/7206 0.0038731073382 ko00010 Glycolysis / Gluconeogenesis 1/780 74/7206 0.00393634962585 ko05140 Leishmaniasis 1/780 75/7206 0.00406000386469 ko04925 Aldosterone synthesis and secretion 3/780 105/7206 0.00408534026342 ko04152 AMPK signaling pathway 7/780 161/7206 0.00454889602808 ko04145 Phagosome 7/780 162/7206 0.00456387652102 ko04912 GnRH signaling pathway 4/780 122/7206 0.00459811605916 ko04666 Fc gamma R-mediated phagocytosis 4/780 122/7206 0.00459811605916 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/780 135/7206 0.00466581818485 ko04146 Peroxisome 2/780 89/7206 0.00515417708289 ko05323 Rheumatoid arthritis 2/780 89/7206 0.00515417708289 ko00562 Inositol phosphate metabolism 2/780 89/7206 0.00515417708289 ko05200 Pathways in cancer 35/780 492/7206 0.00527641252595 ko05418 Fluid shear stress and atherosclerosis 8/780 173/7206 0.00596642929321 ko01230 Biosynthesis of amino acids 2/780 85/7206 0.00737546715296 ko04650 Natural killer cell mediated cytotoxicity 3/780 97/7206 0.00815075092378 ko00564 Glycerophospholipid metabolism 3/780 99/7206 0.00825261956863 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 2/780 79/7206 0.0103805139591 ko04512 ECM-receptor interaction 2/780 79/7206 0.0103805139591 ko04670 Leukocyte transendothelial migration 7/780 151/7206 0.0111804829861 ko04066 HIF-1 signaling pathway 5/780 123/7206 0.0119786618081 ko04660 T cell receptor signaling pathway 5/780 124/7206 0.0121616761742 ko04742 Taste transduction 1/780 61/7206 0.0123227954012 ko00561 Glycerolipid metabolism 1/780 63/7206 0.0126162852575 ko04640 Hematopoietic cell lineage 1/780 64/7206 0.0130224727806 ko04115 p53 signaling pathway 15/780 74/7206 0.013694339496 ko04923 Regulation of lipolysis in adipocytes 2/780 77/7206 0.015021439347 ko05231 Choline metabolism in cancer 6/780 134/7206 0.0159339133976 ko05120 Epithelial cell signaling in Helicobacter pylori infection 3/780 92/7206 0.0164706509444 ko05202 Transcriptional misregulation in cancer 31/780 188/7206 0.0166433375077 ko04962 Vasopressin-regulated water reabsorption 1/780 58/7206 0.0181257483292 ko01212 Fatty acid metabolism 1/780 60/7206 0.0189186418016 ko04540 Gap junction 6/780 128/7206 0.0209059865457 ko05134 Legionellosis 2/780 74/7206 0.0217753566435 ko04918 Thyroid hormone synthesis 3/780 86/7206 0.022418542862 ko04720 Long-term potentiation 4/780 99/7206 0.0225291348269 ko05133 Pertussis 3/780 87/7206 0.0225796736415 ko04662 B cell receptor signaling pathway 3/780 88/7206 0.0229312069283 ko05167 Kaposi's sarcoma-associated herpesvirus infection 11/780 191/7206 0.0239627469696 ko04930 Type II diabetes mellitus 1/780 54/7206 0.0265012056737 ko04722 Neurotrophin signaling pathway 9/780 160/7206 0.0285611542586 ko04064 NF-kappa B signaling pathway 4/780 96/7206 0.0308060770905 ko03060 Protein export 6/780 23/7206 0.0318089040004 ko05162 Measles 6/780 120/7206 0.0371417632554 ko05169 Epstein-Barr virus infection 32/780 206/7206 0.0394756727527 ko04916 Melanogenesis 8/780 142/7206 0.0408449344801 ko05164 Influenza A 10/780 167/7206 0.0429194677879 ko04730 Long-term depression 3/780 78/7206 0.043193314288 ko05016 Huntington's disease 14/780 215/7206 0.0438249663418 ko05160 Hepatitis C 9/780 153/7206 0.0477325852697