ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 41/626 152/7206 1.93685282736e-11 ko04713 Circadian entrainment 35/626 136/7206 2.38202247e-09 ko04728 Dopaminergic synapse 39/626 185/7206 1.56628097307e-07 ko04727 GABAergic synapse 27/626 110/7206 4.65778897278e-07 ko04911 Insulin secretion 27/626 117/7206 1.72016931932e-06 ko04080 Neuroactive ligand-receptor interaction 66/626 423/7206 1.78761326467e-06 ko04726 Serotonergic synapse 29/626 137/7206 4.60207863554e-06 ko04921 Oxytocin signaling pathway 38/626 209/7206 8.79502545484e-06 ko04022 cGMP-PKG signaling pathway 38/626 216/7206 2.11603524285e-05 ko04725 Cholinergic synapse 31/626 160/7206 2.14953964205e-05 ko05031 Amphetamine addiction 21/626 91/7206 2.43568307884e-05 ko04020 Calcium signaling pathway 44/626 265/7206 2.88745113329e-05 ko04922 Glucagon signaling pathway 26/626 128/7206 3.86380042064e-05 ko03040 Spliceosome 1/626 145/7206 3.96146519242e-05 ko04970 Salivary secretion 21/626 95/7206 4.83320741814e-05 ko05032 Morphine addiction 23/626 110/7206 5.43898369746e-05 ko04745 Phototransduction - fly 12/626 38/7206 5.440283081e-05 ko04971 Gastric acid secretion 21/626 98/7206 7.83330577406e-05 ko04720 Long-term potentiation 21/626 99/7206 9.15032417204e-05 ko04070 Phosphatidylinositol signaling system 23/626 112/7206 0.000108048308152 ko03010 Ribosome 1/626 129/7206 0.000195762222886 ko05033 Nicotine addiction 14/626 56/7206 0.000224225640788 ko04744 Phototransduction 10/626 36/7206 0.000721514927858 ko04710 Circadian rhythm 11/626 43/7206 0.000848137726116 ko04730 Long-term depression 16/626 78/7206 0.000905769297156 ko04371 Apelin signaling pathway 29/626 177/7206 0.000971003879055 ko00120 Primary bile acid biosynthesis 7/626 20/7206 0.00102338230221 ko04144 Endocytosis 14/626 342/7206 0.00108896234701 ko04924 Renin secretion 17/626 86/7206 0.00136827455419 ko05014 Amyotrophic lateral sclerosis (ALS) 15/626 74/7206 0.00147367958372 ko04024 cAMP signaling pathway 40/626 279/7206 0.00150653936248 ko04110 Cell cycle 3/626 145/7206 0.00157893404128 ko03013 RNA transport 4/626 166/7206 0.00184150451826 ko04960 Aldosterone-regulated sodium reabsorption 10/626 41/7206 0.00214017360034 ko04925 Aldosterone synthesis and secretion 19/626 105/7206 0.00229542107024 ko04626 Plant-pathogen interaction 6/626 18/7206 0.00313716365882 ko04723 Retrograde endocannabinoid signaling 27/626 175/7206 0.00381979850504 ko04514 Cell adhesion molecules (CAMs) 21/626 130/7206 0.00444510215014 ko05322 Systemic lupus erythematosus 4/626 151/7206 0.00492768457092 ko00010 Glycolysis / Gluconeogenesis 14/626 74/7206 0.0052485030813 ko04966 Collecting duct acid secretion 7/626 26/7206 0.00548557581831 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/626 191/7206 0.00573483434318 ko05203 Viral carcinogenesis 12/626 277/7206 0.00629339504208 ko00230 Purine metabolism 28/626 194/7206 0.00641471649629 ko00680 Methane metabolism 8/626 34/7206 0.00737676609861 ko00051 Fructose and mannose metabolism 9/626 42/7206 0.00874266766464 ko04270 Vascular smooth muscle contraction 23/626 154/7206 0.00878152063564 ko04360 Axon guidance 32/626 233/7206 0.00880218552587 ko04721 Synaptic vesicle cycle 14/626 80/7206 0.00901151570414 ko04972 Pancreatic secretion 18/626 111/7206 0.00949269038421 ko04540 Gap junction 20/626 128/7206 0.010062207923 ko04964 Proximal tubule bicarbonate reclamation 7/626 29/7206 0.0103621052465 ko05130 Pathogenic Escherichia coli infection 1/626 77/7206 0.0133102942257 ko04136 Autophagy - other 7/626 31/7206 0.0150058719012 ko04919 Thyroid hormone signaling pathway 21/626 143/7206 0.0155027231134 ko04810 Regulation of actin cytoskeleton 13/626 264/7206 0.0254389530818 ko05224 Breast cancer 7/626 174/7206 0.0279030606443 ko04137 Mitophagy - animal 13/626 82/7206 0.0285616094637 ko04261 Adrenergic signaling in cardiomyocytes 27/626 205/7206 0.0311651790137 ko05030 Cocaine addiction 12/626 73/7206 0.0325761570708 ko04141 Protein processing in endoplasmic reticulum 8/626 184/7206 0.0330263792615 ko04520 Adherens junction 3/626 103/7206 0.0330658213251 ko00562 Inositol phosphate metabolism 14/626 89/7206 0.0339234720028 ko05166 HTLV-I infection 16/626 292/7206 0.0440648965348 ko05169 Epstein-Barr virus infection 10/626 206/7206 0.0446681453194 ko04068 FoxO signaling pathway 22/626 167/7206 0.0498268304298