ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 40/303 157/7206 3.31692700024e-21 ko05164 Influenza A 38/303 167/7206 2.42499603897e-18 ko04060 Cytokine-cytokine receptor interaction 39/303 191/7206 4.62677863475e-17 ko04064 NF-kappa B signaling pathway 28/303 96/7206 8.51477378981e-17 ko04380 Osteoclast differentiation 32/303 134/7206 3.07548533574e-16 ko05168 Herpes simplex infection 36/303 182/7206 2.36759394332e-15 ko04217 Necroptosis 35/303 178/7206 7.22384693201e-15 ko05140 Leishmaniasis 22/303 75/7206 1.70260556884e-13 ko04620 Toll-like receptor signaling pathway 25/303 100/7206 2.06773082887e-13 ko05162 Measles 27/303 120/7206 3.447720033e-13 ko05152 Tuberculosis 33/303 187/7206 1.12118970955e-12 ko05340 Primary immunodeficiency 14/303 30/7206 3.18170412327e-12 ko05321 Inflammatory bowel disease (IBD) 18/303 56/7206 5.10505405292e-12 ko04659 Th17 cell differentiation 24/303 106/7206 6.49750574974e-12 ko05145 Toxoplasmosis 26/303 126/7206 8.06609834598e-12 ko04622 RIG-I-like receptor signaling pathway 17/303 62/7206 3.41882157042e-10 ko04660 T cell receptor signaling pathway 23/303 124/7206 1.27535689233e-09 ko04658 Th1 and Th2 cell differentiation 20/303 96/7206 1.90283357014e-09 ko05133 Pertussis 19/303 87/7206 2.11150916175e-09 ko05161 Hepatitis B 27/303 173/7206 2.48403122014e-09 ko04612 Antigen processing and presentation 17/303 77/7206 1.27672885188e-08 ko04650 Natural killer cell mediated cytotoxicity 19/303 97/7206 1.4386343171e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/303 191/7206 9.02593885095e-08 ko04668 TNF signaling pathway 20/303 120/7206 1.03372300849e-07 ko04630 Jak-STAT signaling pathway 21/303 132/7206 1.1281905596e-07 ko05323 Rheumatoid arthritis 17/303 89/7206 1.24615708631e-07 ko04672 Intestinal immune network for IgA production 11/303 37/7206 1.94766411814e-07 ko05332 Graft-versus-host disease 8/303 18/7206 2.69998381675e-07 ko05330 Allograft rejection 9/303 24/7206 2.7334584976e-07 ko05160 Hepatitis C 22/303 153/7206 3.50463927768e-07 ko04662 B cell receptor signaling pathway 16/303 88/7206 5.97550822906e-07 ko04623 Cytosolic DNA-sensing pathway 11/303 41/7206 6.1888263179e-07 ko04062 Chemokine signaling pathway 25/303 201/7206 9.25502580235e-07 ko05150 Staphylococcus aureus infection 10/303 36/7206 1.43021894606e-06 ko05144 Malaria 11/303 45/7206 1.70994100486e-06 ko05320 Autoimmune thyroid disease 9/303 29/7206 1.73770285954e-06 ko05142 Chagas disease (American trypanosomiasis) 19/303 130/7206 1.75459319832e-06 ko05310 Asthma 7/303 17/7206 2.93282362067e-06 ko04640 Hematopoietic cell lineage 12/303 64/7206 1.12972342143e-05 ko04210 Apoptosis 21/303 180/7206 1.92593872719e-05 ko04940 Type I diabetes mellitus 8/303 32/7206 3.87291263666e-05 ko05134 Legionellosis 12/303 74/7206 5.175266912e-05 ko04657 IL-17 signaling pathway 13/303 87/7206 6.14104491555e-05 ko04610 Complement and coagulation cascades 12/303 79/7206 0.000100028911344 ko04145 Phagosome 18/303 162/7206 0.000143915712948 ko05131 Shigellosis 12/303 82/7206 0.000144541997742 ko05132 Salmonella infection 13/303 98/7206 0.000212799878981 ko04933 AGE-RAGE signaling pathway in diabetic complications 15/303 135/7206 0.00051263212119 ko05169 Epstein-Barr virus infection 20/303 206/7206 0.000516704011022 ko05034 Alcoholism 1/303 238/7206 0.000762465161399 ko05166 HTLV-I infection 24/303 292/7206 0.00149152680925 ko05016 Huntington's disease 1/303 215/7206 0.00158629508602 ko05416 Viral myocarditis 8/303 55/7206 0.00193327913564 ko05146 Amoebiasis 11/303 99/7206 0.00281073062185 ko04664 Fc epsilon RI signaling pathway 9/303 77/7206 0.00475722872594 ko04728 Dopaminergic synapse 1/303 185/7206 0.00490870703885 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/303 92/7206 0.00505495542598 ko04666 Fc gamma R-mediated phagocytosis 12/303 122/7206 0.00506051284413 ko03050 Proteasome 7/303 54/7206 0.00702928424526 ko04723 Retrograde endocannabinoid signaling 1/303 175/7206 0.00713520505651 ko04310 Wnt signaling pathway 1/303 181/7206 0.00731775374787 ko05143 African trypanosomiasis 5/303 32/7206 0.0100625992288 ko04917 Prolactin signaling pathway 9/303 87/7206 0.0105045430119 ko04514 Cell adhesion molecules (CAMs) 12/303 130/7206 0.0119091915493 ko04670 Leukocyte transendothelial migration 13/303 151/7206 0.0122664372867 ko04510 Focal adhesion 3/303 240/7206 0.0136441960084 ko04152 AMPK signaling pathway 1/303 161/7206 0.0152129881743 ko05418 Fluid shear stress and atherosclerosis 14/303 173/7206 0.0187078480461 ko04360 Axon guidance 3/303 233/7206 0.0189874238202 ko04724 Glutamatergic synapse 1/303 152/7206 0.022060155359 ko05012 Parkinson's disease 1/303 155/7206 0.0227985690027 ko04390 Hippo signaling pathway 2/303 188/7206 0.0251731286484 ko04920 Adipocytokine signaling pathway 8/303 89/7206 0.0329814810015 ko05224 Breast cancer 2/303 174/7206 0.034903819854 ko01523 Antifolate resistance 4/303 30/7206 0.0354798285352 ko04142 Lysosome 12/303 151/7206 0.0359630838283 ko01200 Carbon metabolism 1/303 128/7206 0.0447467864931 ko04922 Glucagon signaling pathway 1/303 128/7206 0.0447467864931 ko00190 Oxidative phosphorylation 1/303 127/7206 0.0447713339886 ko04713 Circadian entrainment 1/303 136/7206 0.0471523108896 ko04611 Platelet activation 12/303 163/7206 0.0484760621049 ko00120 Primary bile acid biosynthesis 3/303 20/7206 0.0494032854614