ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1234	423/7206	1.14669577408e-59
ko04724	Glutamatergic synapse	91/1234	152/7206	5.11962543707e-33
ko05033	Nicotine addiction	50/1234	56/7206	2.33466375386e-32
ko05032	Morphine addiction	71/1234	110/7206	6.81207070375e-29
ko04727	GABAergic synapse	68/1234	110/7206	4.54532435223e-26
ko04713	Circadian entrainment	76/1234	136/7206	5.05200825583e-25
ko04728	Dopaminergic synapse	89/1234	185/7206	5.64409686745e-23
ko04725	Cholinergic synapse	79/1234	160/7206	2.13852050054e-21
ko04721	Synaptic vesicle cycle	51/1234	80/7206	1.05656591608e-20
ko04024	cAMP signaling pathway	111/1234	279/7206	5.2718426347e-20
ko04020	Calcium signaling pathway	107/1234	265/7206	6.09069997752e-20
ko04723	Retrograde endocannabinoid signaling	78/1234	175/7206	8.8610770847e-18
ko04911	Insulin secretion	59/1234	117/7206	8.09795683047e-17
ko04742	Taste transduction	37/1234	61/7206	2.35743127133e-14
ko04744	Phototransduction	27/1234	36/7206	3.07107622242e-14
ko04921	Oxytocin signaling pathway	81/1234	209/7206	4.07635578388e-14
ko04726	Serotonergic synapse	60/1234	137/7206	1.57207466373e-13
ko04720	Long-term potentiation	47/1234	99/7206	2.0217173333e-12
ko05031	Amphetamine addiction	44/1234	91/7206	4.69982786326e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1234	205/7206	4.91998894724e-12
ko04360	Axon guidance	82/1234	233/7206	1.78534584243e-11
ko03040	Spliceosome	1/1234	145/7206	7.29580126601e-11
ko04970	Salivary secretion	43/1234	95/7206	1.254252984e-10
ko05168	Herpes simplex infection	6/1234	182/7206	1.04097517185e-08
ko05203	Viral carcinogenesis	16/1234	277/7206	1.95784138722e-08
ko04740	Olfactory transduction	35/1234	80/7206	1.99716703181e-08
ko05030	Cocaine addiction	32/1234	73/7206	7.64862976524e-08
ko04971	Gastric acid secretion	39/1234	98/7206	8.31456347186e-08
ko05322	Systemic lupus erythematosus	5/1234	151/7206	1.63580719782e-07
ko04925	Aldosterone synthesis and secretion	40/1234	105/7206	2.59693108422e-07
ko04022	cGMP-PKG signaling pathway	67/1234	216/7206	3.21265738237e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1234	74/7206	4.22285532095e-07
ko03013	RNA transport	7/1234	166/7206	5.74759372499e-07
ko04060	Cytokine-cytokine receptor interaction	10/1234	191/7206	1.22710336065e-06
ko04010	MAPK signaling pathway	89/1234	321/7206	1.42603758824e-06
ko04972	Pancreatic secretion	38/1234	111/7206	1.02423679277e-05
ko04070	Phosphatidylinositol signaling system	38/1234	112/7206	1.22605867199e-05
ko04610	Complement and coagulation cascades	1/1234	79/7206	1.31009058204e-05
ko04745	Phototransduction - fly	18/1234	38/7206	1.50123298228e-05
ko04141	Protein processing in endoplasmic reticulum	12/1234	184/7206	2.63188517298e-05
ko04730	Long-term depression	28/1234	78/7206	5.5805170088e-05
ko04924	Renin secretion	30/1234	86/7206	6.52698737342e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1234	79/7206	6.93652525679e-05
ko04540	Gap junction	40/1234	128/7206	7.33588766907e-05
ko05164	Influenza A	11/1234	167/7206	9.87577624193e-05
ko05205	Proteoglycans in cancer	24/1234	271/7206	0.000102047690659
ko03008	Ribosome biogenesis in eukaryotes	2/1234	79/7206	0.000113727629169
ko04966	Collecting duct acid secretion	13/1234	26/7206	0.000117128749576
ko05140	Leishmaniasis	2/1234	75/7206	0.000159802713904
ko05414	Dilated cardiomyopathy	35/1234	112/7206	0.000202768842827
ko04514	Cell adhesion molecules (CAMs)	39/1234	130/7206	0.000233959494729
ko04072	Phospholipase D signaling pathway	54/1234	197/7206	0.000241888825135
ko04621	NOD-like receptor signaling pathway	11/1234	157/7206	0.000247953891361
ko05110	Vibrio cholerae infection	23/1234	63/7206	0.00026652687782
ko04260	Cardiac muscle contraction	31/1234	98/7206	0.000369555923067
ko04915	Estrogen signaling pathway	38/1234	131/7206	0.000616209646424
ko04014	Ras signaling pathway	70/1234	279/7206	0.000620429830267
ko04612	Antigen processing and presentation	3/1234	77/7206	0.00067410688743
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1234	59/7206	0.000674140292051
ko04064	NF-kappa B signaling pathway	5/1234	96/7206	0.000883114689001
ko04120	Ubiquitin mediated proteolysis	10/1234	138/7206	0.00124145919841
ko00240	Pyrimidine metabolism	7/1234	110/7206	0.00129019225708
ko04626	Plant-pathogen interaction	9/1234	18/7206	0.00136177641139
ko05169	Epstein-Barr virus infection	19/1234	206/7206	0.00137320388964
ko04371	Apelin signaling pathway	47/1234	177/7206	0.00159551941953
ko04923	Regulation of lipolysis in adipocytes	24/1234	77/7206	0.00210890573977
ko04146	Peroxisome	5/1234	89/7206	0.0025419611337
ko03420	Nucleotide excision repair	1/1234	46/7206	0.00281494216066
ko00260	Glycine, serine and threonine metabolism	1/1234	48/7206	0.00301672855856
ko05162	Measles	9/1234	120/7206	0.00313660208462
ko04750	Inflammatory mediator regulation of TRP channels	34/1234	122/7206	0.00328684576123
ko04110	Cell cycle	12/1234	145/7206	0.00350249838556
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1234	182/7206	0.0036681348249
ko00480	Glutathione metabolism	2/1234	55/7206	0.00373446820945
ko05321	Inflammatory bowel disease (IBD)	2/1234	56/7206	0.00375297258129
ko05161	Hepatitis B	16/1234	173/7206	0.00405616237192
ko04976	Bile secretion	24/1234	80/7206	0.00410013821363
ko03022	Basal transcription factors	1/1234	44/7206	0.00424724461518
ko04640	Hematopoietic cell lineage	3/1234	64/7206	0.0043299252741
ko05144	Malaria	1/1234	45/7206	0.00437903248277
ko00071	Fatty acid degradation	1/1234	45/7206	0.00437903248277
ko00310	Lysine degradation	4/1234	73/7206	0.00466013167117
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1234	14/7206	0.00476712694404
ko05131	Shigellosis	5/1234	82/7206	0.00479059005652
ko03018	RNA degradation	5/1234	84/7206	0.00499928335121
ko04622	RIG-I-like receptor signaling pathway	3/1234	62/7206	0.00622226778857
ko04214	Apoptosis - fly	4/1234	72/7206	0.00672632874246
ko00590	Arachidonic acid metabolism	2/1234	52/7206	0.00834109758838
ko05133	Pertussis	6/1234	87/7206	0.0092059009799
ko00330	Arginine and proline metabolism	3/1234	61/7206	0.00925078389347
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1234	40/7206	0.00983369936588
ko04912	GnRH signaling pathway	32/1234	122/7206	0.0104555414796
ko04916	Melanogenesis	36/1234	142/7206	0.0127760363334
ko04115	p53 signaling pathway	5/1234	74/7206	0.0129118536411
ko04630	Jak-STAT signaling pathway	12/1234	132/7206	0.0136759275966
ko00982	Drug metabolism - cytochrome P450	1/1234	37/7206	0.0144965013907
ko04015	Rap1 signaling pathway	63/1234	278/7206	0.0147712991947
ko00630	Glyoxylate and dicarboxylate metabolism	1/1234	38/7206	0.0150656303073
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1234	100/7206	0.0151873957271
ko04658	Th1 and Th2 cell differentiation	8/1234	96/7206	0.0197314593133
ko04918	Thyroid hormone synthesis	23/1234	86/7206	0.0212236516607
ko04657	IL-17 signaling pathway	7/1234	87/7206	0.0213922176488
ko00562	Inositol phosphate metabolism	24/1234	89/7206	0.0222180598951
ko04964	Proximal tubule bicarbonate reclamation	10/1234	29/7206	0.0224949333121
ko05145	Toxoplasmosis	12/1234	126/7206	0.0226706376605
ko04922	Glucagon signaling pathway	32/1234	128/7206	0.0236957193737
ko03320	PPAR signaling pathway	5/1234	69/7206	0.0244596553297
ko05016	Huntington's disease	25/1234	215/7206	0.0274974777051
ko04670	Leukocyte transendothelial migration	16/1234	151/7206	0.0290129241571
ko01524	Platinum drug resistance	6/1234	76/7206	0.0311867961335
ko04620	Toll-like receptor signaling pathway	9/1234	100/7206	0.0314330039937
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1234	26/7206	0.031503364228
ko01200	Carbon metabolism	13/1234	128/7206	0.032968587667
ko00140	Steroid hormone biosynthesis	2/1234	41/7206	0.0359618754944
ko00983	Drug metabolism - other enzymes	2/1234	42/7206	0.0369321008069
ko04137	Mitophagy - animal	7/1234	82/7206	0.0382145059659
ko04114	Oocyte meiosis	33/1234	139/7206	0.0407147198874
ko05320	Autoimmune thyroid disease	1/1234	29/7206	0.0481341200546