ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 25/532 56/7206 1.88023698599e-14 ko04360 Axon guidance 53/532 233/7206 4.15741388836e-14 ko04721 Synaptic vesicle cycle 27/532 80/7206 5.49847729352e-12 ko04724 Glutamatergic synapse 38/532 152/7206 9.61175484058e-12 ko04727 GABAergic synapse 31/532 110/7206 3.03148605678e-11 ko05032 Morphine addiction 30/532 110/7206 1.55989673142e-10 ko04723 Retrograde endocannabinoid signaling 37/532 175/7206 3.06539472578e-09 ko04728 Dopaminergic synapse 38/532 185/7206 4.38731372031e-09 ko04024 cAMP signaling pathway 46/532 279/7206 2.35557798082e-07 ko04713 Circadian entrainment 27/532 136/7206 1.62030191162e-06 ko04514 Cell adhesion molecules (CAMs) 26/532 130/7206 2.18651056574e-06 ko04911 Insulin secretion 24/532 117/7206 3.37987029622e-06 ko04725 Cholinergic synapse 29/532 160/7206 4.61684375756e-06 ko04010 MAPK signaling pathway 46/532 321/7206 9.48066210577e-06 ko04261 Adrenergic signaling in cardiomyocytes 33/532 205/7206 1.6653619625e-05 ko05322 Systemic lupus erythematosus 1/532 151/7206 0.000209388026352 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/532 14/7206 0.000283052759254 ko03040 Spliceosome 1/532 145/7206 0.000306334835327 ko04921 Oxytocin signaling pathway 30/532 209/7206 0.000385378479388 ko05203 Viral carcinogenesis 7/532 277/7206 0.000604111450061 ko04080 Neuroactive ligand-receptor interaction 50/532 423/7206 0.00073374175126 ko04391 Hippo signaling pathway - fly 16/532 90/7206 0.000792657672713 ko01200 Carbon metabolism 1/532 128/7206 0.000969962891558 ko04726 Serotonergic synapse 21/532 137/7206 0.00131040779908 ko04070 Phosphatidylinositol signaling system 18/532 112/7206 0.0014833725249 ko04071 Sphingolipid signaling pathway 23/532 162/7206 0.00207218573868 ko05030 Cocaine addiction 13/532 73/7206 0.00236289277119 ko03013 RNA transport 3/532 166/7206 0.00236441869024 ko04970 Salivary secretion 15/532 95/7206 0.00448911080389 ko04972 Pancreatic secretion 17/532 111/7206 0.00487019673978 ko05210 Colorectal cancer 14/532 86/7206 0.00518474796973 ko00562 Inositol phosphate metabolism 14/532 89/7206 0.00635236433371 ko04072 Phospholipase D signaling pathway 25/532 197/7206 0.00786729419545 ko00515 Mannose type O-glycan biosynthesis 6/532 25/7206 0.00830570507267 ko04141 Protein processing in endoplasmic reticulum 5/532 184/7206 0.00970520328469 ko04730 Long-term depression 12/532 78/7206 0.0137496742996 ko04146 Peroxisome 1/532 89/7206 0.0138218078488 ko05016 Huntington's disease 7/532 215/7206 0.0163200725909 ko04964 Proximal tubule bicarbonate reclamation 6/532 29/7206 0.0173381466162 ko05142 Chagas disease (American trypanosomiasis) 17/532 130/7206 0.0174336593079 ko04144 Endocytosis 37/532 342/7206 0.0190590997389 ko03018 RNA degradation 1/532 84/7206 0.020066623513 ko01230 Biosynthesis of amino acids 1/532 85/7206 0.0201367099473 ko05213 Endometrial cancer 10/532 62/7206 0.0229612299569 ko04060 Cytokine-cytokine receptor interaction 6/532 191/7206 0.0234234556525 ko04022 cGMP-PKG signaling pathway 25/532 216/7206 0.0236831681558 ko05168 Herpes simplex infection 6/532 182/7206 0.0303256524648 ko04260 Cardiac muscle contraction 13/532 98/7206 0.0319632902043 ko05205 Proteoglycans in cancer 11/532 271/7206 0.0322982100961 ko04390 Hippo signaling pathway 22/532 188/7206 0.0323308481296 ko04973 Carbohydrate digestion and absorption 7/532 42/7206 0.0323608713688 ko04014 Ras signaling pathway 30/532 279/7206 0.0348327045996 ko04915 Estrogen signaling pathway 16/532 131/7206 0.0415378629707 ko05160 Hepatitis C 18/532 153/7206 0.041978376379 ko04612 Antigen processing and presentation 1/532 77/7206 0.0439872909462 ko04744 Phototransduction 6/532 36/7206 0.0460523370014 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/532 79/7206 0.0462544007084 ko04064 NF-kappa B signaling pathway 2/532 96/7206 0.0467112654167 ko05110 Vibrio cholerae infection 9/532 63/7206 0.0482192902282 ko04550 Signaling pathways regulating pluripotency of stem cells 19/532 165/7206 0.048867800371 ko04720 Long-term potentiation 13/532 99/7206 0.0488895087464