ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	164/1053	423/7206	7.93854523244e-37
ko04724	Glutamatergic synapse	81/1053	152/7206	1.28917533098e-29
ko05033	Nicotine addiction	46/1053	56/7206	1.30406494729e-29
ko05032	Morphine addiction	64/1053	110/7206	1.72891997406e-26
ko04727	GABAergic synapse	62/1053	110/7206	1.18646821011e-24
ko04721	Synaptic vesicle cycle	47/1053	80/7206	5.43024259022e-20
ko04728	Dopaminergic synapse	77/1053	185/7206	1.26601249837e-19
ko04723	Retrograde endocannabinoid signaling	74/1053	175/7206	2.23757218223e-19
ko04713	Circadian entrainment	63/1053	136/7206	4.1966702969e-19
ko04725	Cholinergic synapse	67/1053	160/7206	2.24121630275e-17
ko04742	Taste transduction	37/1053	61/7206	1.21188848948e-16
ko04744	Phototransduction	26/1053	36/7206	8.49948292646e-15
ko04726	Serotonergic synapse	55/1053	137/7206	1.50838968472e-13
ko04024	cAMP signaling pathway	87/1053	279/7206	6.05766162484e-13
ko04911	Insulin secretion	47/1053	117/7206	8.98650426072e-12
ko04261	Adrenergic signaling in cardiomyocytes	63/1053	205/7206	2.28983473737e-09
ko03040	Spliceosome	1/1053	145/7206	3.54025073596e-09
ko04020	Calcium signaling pathway	75/1053	265/7206	4.34563270008e-09
ko04921	Oxytocin signaling pathway	63/1053	209/7206	6.12885680521e-09
ko05203	Viral carcinogenesis	12/1053	277/7206	2.9495624406e-08
ko05031	Amphetamine addiction	33/1053	91/7206	2.14703362471e-07
ko04740	Olfactory transduction	30/1053	80/7206	3.28844081139e-07
ko04720	Long-term potentiation	34/1053	99/7206	7.68210073697e-07
ko03013	RNA transport	5/1053	166/7206	1.06245712932e-06
ko05030	Cocaine addiction	27/1053	73/7206	1.74294537645e-06
ko04970	Salivary secretion	32/1053	95/7206	2.43394317016e-06
ko05168	Herpes simplex infection	7/1053	182/7206	3.30549643247e-06
ko05164	Influenza A	6/1053	167/7206	3.987897019e-06
ko05205	Proteoglycans in cancer	16/1053	271/7206	6.58328890293e-06
ko04514	Cell adhesion molecules (CAMs)	39/1053	130/7206	6.74931597502e-06
ko05322	Systemic lupus erythematosus	5/1053	151/7206	6.81434072495e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1053	79/7206	3.40563903214e-05
ko04260	Cardiac muscle contraction	30/1053	98/7206	4.03540214785e-05
ko04971	Gastric acid secretion	30/1053	98/7206	4.03540214785e-05
ko04120	Ubiquitin mediated proteolysis	5/1053	138/7206	4.32288683328e-05
ko04360	Axon guidance	57/1053	233/7206	6.25400627047e-05
ko04060	Cytokine-cytokine receptor interaction	10/1053	191/7206	6.40743571259e-05
ko04925	Aldosterone synthesis and secretion	31/1053	105/7206	7.06097782081e-05
ko04610	Complement and coagulation cascades	1/1053	79/7206	8.24177577036e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1053	79/7206	8.24177577036e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	24/1053	74/7206	8.75937018278e-05
ko04141	Protein processing in endoplasmic reticulum	10/1053	184/7206	0.000118426259027
ko04972	Pancreatic secretion	31/1053	111/7206	0.000217238294313
ko04621	NOD-like receptor signaling pathway	8/1053	157/7206	0.000218262242836
ko04010	MAPK signaling pathway	71/1053	321/7206	0.000250970168751
ko05162	Measles	5/1053	120/7206	0.000359421659229
ko04966	Collecting duct acid secretion	11/1053	26/7206	0.000575464830186
ko04730	Long-term depression	23/1053	78/7206	0.000595398880435
ko05169	Epstein-Barr virus infection	14/1053	206/7206	0.000622104373849
ko04022	cGMP-PKG signaling pathway	50/1053	216/7206	0.000798328608708
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1053	182/7206	0.000938502294198
ko04072	Phospholipase D signaling pathway	46/1053	197/7206	0.000966744600322
ko05161	Hepatitis B	11/1053	173/7206	0.000988654209411
ko05140	Leishmaniasis	2/1053	75/7206	0.0014093715994
ko03018	RNA degradation	3/1053	84/7206	0.00165678938779
ko04070	Phosphatidylinositol signaling system	29/1053	112/7206	0.00166158928013
ko04964	Proximal tubule bicarbonate reclamation	11/1053	29/7206	0.00169478914571
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1053	14/7206	0.00186612025127
ko04064	NF-kappa B signaling pathway	4/1053	96/7206	0.00191324256334
ko04214	Apoptosis - fly	2/1053	72/7206	0.00204900836027
ko04976	Bile secretion	22/1053	80/7206	0.00225998485222
ko04140	Autophagy - animal	11/1053	164/7206	0.00236799292576
ko00480	Glutathione metabolism	1/1053	55/7206	0.00327123512962
ko04146	Peroxisome	4/1053	89/7206	0.00373802836972
ko05414	Dilated cardiomyopathy	28/1053	112/7206	0.00413297295001
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1053	59/7206	0.00455377557381
ko00590	Arachidonic acid metabolism	1/1053	52/7206	0.00485810020898
ko04612	Antigen processing and presentation	3/1053	77/7206	0.00504409258052
ko04640	Hematopoietic cell lineage	2/1053	64/7206	0.00649738064179
ko05166	HTLV-I infection	27/1053	292/7206	0.0066721753234
ko05145	Toxoplasmosis	8/1053	126/7206	0.00696608737637
ko00260	Glycine, serine and threonine metabolism	1/1053	48/7206	0.0071721165101
ko04540	Gap junction	30/1053	128/7206	0.00747991959422
ko04924	Renin secretion	22/1053	86/7206	0.00805165659617
ko04745	Phototransduction - fly	12/1053	38/7206	0.00856467198778
ko00330	Arginine and proline metabolism	2/1053	61/7206	0.00935870198219
ko04217	Necroptosis	14/1053	178/7206	0.00944817171612
ko00240	Pyrimidine metabolism	7/1053	110/7206	0.00963410405424
ko05144	Malaria	1/1053	45/7206	0.0106986015334
ko00071	Fatty acid degradation	1/1053	45/7206	0.0106986015334
ko03420	Nucleotide excision repair	1/1053	46/7206	0.0107087689017
ko04915	Estrogen signaling pathway	30/1053	131/7206	0.0117925733861
ko04110	Cell cycle	11/1053	145/7206	0.0124414736364
ko05321	Inflammatory bowel disease (IBD)	2/1053	56/7206	0.012944047936
ko05133	Pertussis	5/1053	87/7206	0.0141877500232
ko03022	Basal transcription factors	1/1053	44/7206	0.0162480156154
ko04630	Jak-STAT signaling pathway	10/1053	132/7206	0.0178546059094
ko00280	Valine, leucine and isoleucine degradation	2/1053	54/7206	0.018811285157
ko04658	Th1 and Th2 cell differentiation	6/1053	96/7206	0.0188133070048
ko01524	Platinum drug resistance	4/1053	76/7206	0.0206209527132
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1053	40/7206	0.0235381988297
ko04014	Ras signaling pathway	54/1053	279/7206	0.0246790762927
ko04210	Apoptosis	16/1053	180/7206	0.0248164202942
ko05131	Shigellosis	5/1053	82/7206	0.0266202492198
ko04137	Mitophagy - animal	5/1053	82/7206	0.0266202492198
ko00380	Tryptophan metabolism	2/1053	50/7206	0.0269034282281
ko04622	RIG-I-like receptor signaling pathway	3/1053	62/7206	0.0283385524641
ko00310	Lysine degradation	4/1053	73/7206	0.0284325940749
ko05215	Prostate cancer	8/1053	111/7206	0.0289564740022
ko00561	Glycerolipid metabolism	3/1053	63/7206	0.0291673242935
ko01200	Carbon metabolism	10/1053	128/7206	0.0307338040241
ko04620	Toll-like receptor signaling pathway	7/1053	100/7206	0.0312296496522
ko00982	Drug metabolism - cytochrome P450	1/1053	37/7206	0.0348271385041
ko03320	PPAR signaling pathway	4/1053	69/7206	0.0382741237496
ko00270	Cysteine and methionine metabolism	2/1053	47/7206	0.0385882539169
ko05219	Bladder cancer	2/1053	48/7206	0.0386818722279
ko04750	Inflammatory mediator regulation of TRP channels	26/1053	122/7206	0.0387841715065
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1053	26/7206	0.0439410877357
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1053	100/7206	0.044686177506
ko04657	IL-17 signaling pathway	6/1053	87/7206	0.0454100176582
ko05110	Vibrio cholerae infection	15/1053	63/7206	0.0473394267933
ko00562	Inositol phosphate metabolism	20/1053	89/7206	0.0477528205876
ko05418	Fluid shear stress and atherosclerosis	16/1053	173/7206	0.0489638697771