ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1171	423/7206	2.05432494162e-53
ko04724	Glutamatergic synapse	91/1171	152/7206	6.79011783408e-35
ko05033	Nicotine addiction	49/1171	56/7206	6.59389671362e-32
ko04727	GABAergic synapse	70/1171	110/7206	2.14162951959e-29
ko05032	Morphine addiction	69/1171	110/7206	1.99845846043e-28
ko04713	Circadian entrainment	76/1171	136/7206	1.53941364965e-26
ko04725	Cholinergic synapse	77/1171	160/7206	1.86215546963e-21
ko04728	Dopaminergic synapse	84/1171	185/7206	3.19516837746e-21
ko04721	Synaptic vesicle cycle	49/1171	80/7206	7.39210899862e-20
ko04723	Retrograde endocannabinoid signaling	79/1171	175/7206	7.96136834056e-20
ko04024	cAMP signaling pathway	105/1171	279/7206	1.21763005465e-18
ko04911	Insulin secretion	59/1171	117/7206	6.18516376492e-18
ko04742	Taste transduction	39/1171	61/7206	5.4647088256e-17
ko04726	Serotonergic synapse	61/1171	137/7206	3.22346742195e-15
ko04740	Olfactory transduction	43/1171	80/7206	1.07255882518e-14
ko04020	Calcium signaling pathway	93/1171	265/7206	2.42651493242e-14
ko04744	Phototransduction	26/1171	36/7206	1.15386132705e-13
ko04921	Oxytocin signaling pathway	77/1171	209/7206	2.44724400953e-13
ko04720	Long-term potentiation	45/1171	99/7206	6.08660905404e-12
ko05031	Amphetamine addiction	42/1171	91/7206	1.67925863909e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1171	205/7206	6.46863096384e-11
ko04970	Salivary secretion	42/1171	95/7206	9.3509499999e-11
ko03040	Spliceosome	1/1171	145/7206	3.23840633972e-10
ko04925	Aldosterone synthesis and secretion	42/1171	105/7206	3.96426661662e-09
ko04971	Gastric acid secretion	40/1171	98/7206	4.65475466503e-09
ko05203	Viral carcinogenesis	14/1171	277/7206	9.68063226159e-09
ko04360	Axon guidance	72/1171	233/7206	1.96578116288e-08
ko05030	Cocaine addiction	32/1171	73/7206	2.11153738345e-08
ko04060	Cytokine-cytokine receptor interaction	7/1171	191/7206	4.64430429058e-08
ko05168	Herpes simplex infection	7/1171	182/7206	2.09057694955e-07
ko04022	cGMP-PKG signaling pathway	63/1171	216/7206	1.28718860327e-06
ko03013	RNA transport	7/1171	166/7206	1.88977758873e-06
ko04972	Pancreatic secretion	38/1171	111/7206	2.97159765173e-06
ko05322	Systemic lupus erythematosus	6/1171	151/7206	3.31419845272e-06
ko04010	MAPK signaling pathway	83/1171	321/7206	6.28772621145e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1171	74/7206	7.55925785719e-06
ko04540	Gap junction	41/1171	128/7206	8.58639048939e-06
ko04141	Protein processing in endoplasmic reticulum	10/1171	184/7206	1.02573313406e-05
ko04730	Long-term depression	28/1171	78/7206	1.91195416293e-05
ko04610	Complement and coagulation cascades	1/1171	79/7206	2.03544711412e-05
ko04120	Ubiquitin mediated proteolysis	6/1171	138/7206	2.05439727905e-05
ko05164	Influenza A	9/1171	167/7206	2.70611146149e-05
ko04745	Phototransduction - fly	17/1171	38/7206	3.23478502024e-05
ko04514	Cell adhesion molecules (CAMs)	40/1171	130/7206	3.25101462258e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1171	79/7206	3.64310667747e-05
ko04260	Cardiac muscle contraction	32/1171	98/7206	4.79664541167e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1171	59/7206	0.000100687739009
ko04621	NOD-like receptor signaling pathway	9/1171	157/7206	0.000104314003219
ko04072	Phospholipase D signaling pathway	53/1171	197/7206	0.000116077335603
ko04924	Renin secretion	28/1171	86/7206	0.000168770493292
ko03008	Ribosome biogenesis in eukaryotes	2/1171	79/7206	0.000171795393205
ko05110	Vibrio cholerae infection	22/1171	63/7206	0.000237612505431
ko05162	Measles	6/1171	120/7206	0.000245346034992
ko04976	Bile secretion	26/1171	80/7206	0.000326267130223
ko05169	Epstein-Barr virus infection	16/1171	206/7206	0.000368319266092
ko04110	Cell cycle	9/1171	145/7206	0.000373493395016
ko05414	Dilated cardiomyopathy	33/1171	112/7206	0.000405147235239
ko04915	Estrogen signaling pathway	37/1171	131/7206	0.000456855794118
ko04750	Inflammatory mediator regulation of TRP channels	35/1171	122/7206	0.000457945543174
ko04014	Ras signaling pathway	67/1171	279/7206	0.000647092953255
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1171	182/7206	0.00101999707205
ko04070	Phosphatidylinositol signaling system	32/1171	112/7206	0.00105691962388
ko04146	Peroxisome	4/1171	89/7206	0.0012189635554
ko00520	Amino sugar and nucleotide sugar metabolism	1/1171	55/7206	0.00134635975921
ko00480	Glutathione metabolism	1/1171	55/7206	0.00134635975921
ko04966	Collecting duct acid secretion	11/1171	26/7206	0.00143925650016
ko04612	Antigen processing and presentation	3/1171	77/7206	0.0015492754804
ko04371	Apelin signaling pathway	45/1171	177/7206	0.0018058029952
ko05205	Proteoglycans in cancer	26/1171	271/7206	0.00181560554826
ko04640	Hematopoietic cell lineage	2/1171	64/7206	0.00181575339229
ko04064	NF-kappa B signaling pathway	5/1171	96/7206	0.00187161100354
ko00590	Arachidonic acid metabolism	1/1171	52/7206	0.00198781661455
ko05140	Leishmaniasis	3/1171	75/7206	0.00230239369375
ko03018	RNA degradation	4/1171	84/7206	0.00249636352998
ko00240	Pyrimidine metabolism	7/1171	110/7206	0.00258764652011
ko04214	Apoptosis - fly	3/1171	72/7206	0.00325345169359
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1171	14/7206	0.00350949452053
ko03420	Nucleotide excision repair	1/1171	46/7206	0.00443452186718
ko05418	Fluid shear stress and atherosclerosis	15/1171	173/7206	0.00467002051958
ko00260	Glycine, serine and threonine metabolism	1/1171	48/7206	0.00474910393152
ko04658	Th1 and Th2 cell differentiation	6/1171	96/7206	0.00498796254867
ko04657	IL-17 signaling pathway	5/1171	87/7206	0.00501696967154
ko04916	Melanogenesis	36/1171	142/7206	0.00543350159182
ko05321	Inflammatory bowel disease (IBD)	2/1171	56/7206	0.00571635074523
ko04350	TGF-beta signaling pathway	7/1171	103/7206	0.00665881441403
ko03022	Basal transcription factors	1/1171	44/7206	0.00668299992021
ko05144	Malaria	1/1171	45/7206	0.0069221203072
ko00071	Fatty acid degradation	1/1171	45/7206	0.0069221203072
ko04923	Regulation of lipolysis in adipocytes	22/1171	77/7206	0.00734061997639
ko04270	Vascular smooth muscle contraction	38/1171	154/7206	0.00760481590353
ko04912	GnRH signaling pathway	31/1171	122/7206	0.00885880839559
ko05161	Hepatitis B	16/1171	173/7206	0.00902866135662
ko04978	Mineral absorption	13/1171	40/7206	0.00921110685343
ko04622	RIG-I-like receptor signaling pathway	3/1171	62/7206	0.00929005919124
ko00600	Sphingolipid metabolism	3/1171	63/7206	0.00929208567289
ko00310	Lysine degradation	4/1171	73/7206	0.00978895628097
ko05145	Toxoplasmosis	10/1171	126/7206	0.00991530578313
ko04918	Thyroid hormone synthesis	23/1171	86/7206	0.0118521751053
ko04015	Rap1 signaling pathway	61/1171	278/7206	0.012566329692
ko00330	Arginine and proline metabolism	3/1171	61/7206	0.0133967220297
ko03320	PPAR signaling pathway	4/1171	69/7206	0.0135187725642
ko04062	Chemokine signaling pathway	46/1171	201/7206	0.0148710278728
ko03410	Base excision repair	1/1171	38/7206	0.0149555553307
ko01200	Carbon metabolism	11/1171	128/7206	0.0153026106797
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1171	40/7206	0.0155632128528
ko05133	Pertussis	6/1171	87/7206	0.01807259247
ko04973	Carbohydrate digestion and absorption	13/1171	42/7206	0.0182566289985
ko01524	Platinum drug resistance	5/1171	76/7206	0.0183730181169
ko04964	Proximal tubule bicarbonate reclamation	10/1171	29/7206	0.0185692188199
ko05166	HTLV-I infection	33/1171	292/7206	0.0186348656115
ko04620	Toll-like receptor signaling pathway	8/1171	100/7206	0.0203048014991
ko00982	Drug metabolism - cytochrome P450	1/1171	37/7206	0.0227599879796
ko05131	Shigellosis	6/1171	82/7206	0.0236924923652
ko04140	Autophagy - animal	16/1171	164/7206	0.0238742433256
ko04115	p53 signaling pathway	5/1171	74/7206	0.0253547402401
ko04930	Type II diabetes mellitus	15/1171	54/7206	0.0265343264202
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1171	100/7206	0.0276699272589
ko05034	Alcoholism	51/1171	238/7206	0.0317942386157
ko04668	TNF signaling pathway	11/1171	120/7206	0.0333812409647
ko04113	Meiosis - yeast	5/1171	70/7206	0.0343307607286
ko05215	Prostate cancer	10/1171	111/7206	0.0373952873067
ko00280	Valine, leucine and isoleucine degradation	3/1171	54/7206	0.0389102922479
ko05016	Huntington's disease	24/1171	215/7206	0.0389371546447
ko04217	Necroptosis	19/1171	178/7206	0.0396700045528
ko04210	Apoptosis	19/1171	180/7206	0.039994243725
ko00512	Mucin type O-glycan biosynthesis	9/1171	29/7206	0.0412420098724
ko04630	Jak-STAT signaling pathway	13/1171	132/7206	0.0429273220422
ko04136	Autophagy - other	1/1171	31/7206	0.0493622850243