ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 36/421 152/7206 1.84124167314e-13 ko04744 Phototransduction 17/421 36/7206 2.41324139301e-12 ko04727 GABAergic synapse 29/421 110/7206 2.53965140188e-12 ko04728 Dopaminergic synapse 38/421 185/7206 4.43403291502e-12 ko04721 Synaptic vesicle cycle 23/421 80/7206 7.30799541462e-11 ko04725 Cholinergic synapse 33/421 160/7206 1.08632623766e-10 ko05033 Nicotine addiction 16/421 56/7206 6.63969143495e-08 ko04723 Retrograde endocannabinoid signaling 30/421 175/7206 7.21514413096e-08 ko04911 Insulin secretion 23/421 117/7206 2.00173871547e-07 ko04713 Circadian entrainment 25/421 136/7206 2.30105280275e-07 ko05032 Morphine addiction 22/421 110/7206 2.69813744708e-07 ko04726 Serotonergic synapse 24/421 137/7206 1.00816747438e-06 ko04360 Axon guidance 32/421 233/7206 5.13846867888e-06 ko04024 cAMP signaling pathway 34/421 279/7206 3.74758591455e-05 ko04514 Cell adhesion molecules (CAMs) 20/421 130/7206 5.7866923625e-05 ko05203 Viral carcinogenesis 3/421 277/7206 0.000109748950266 ko04964 Proximal tubule bicarbonate reclamation 8/421 29/7206 0.000183427067915 ko04261 Adrenergic signaling in cardiomyocytes 25/421 205/7206 0.000398049125133 ko04071 Sphingolipid signaling pathway 21/421 162/7206 0.000503164138227 ko04010 MAPK signaling pathway 33/421 321/7206 0.00137000528626 ko04720 Long-term potentiation 14/421 99/7206 0.00171608384563 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/421 59/7206 0.00197863512056 ko04960 Aldosterone-regulated sodium reabsorption 8/421 41/7206 0.00220242647754 ko05031 Amphetamine addiction 13/421 91/7206 0.00226213955263 ko05322 Systemic lupus erythematosus 1/421 151/7206 0.00228098065614 ko05030 Cocaine addiction 11/421 73/7206 0.0031626452098 ko04970 Salivary secretion 13/421 95/7206 0.00333113694 ko03040 Spliceosome 1/421 145/7206 0.00337505643259 ko05014 Amyotrophic lateral sclerosis (ALS) 11/421 74/7206 0.00352523960601 ko04020 Calcium signaling pathway 27/421 265/7206 0.0045655233299 ko04730 Long-term depression 11/421 78/7206 0.00532165885012 ko04745 Phototransduction - fly 7/421 38/7206 0.00575652353912 ko04972 Pancreatic secretion 14/421 111/7206 0.00620392642917 ko04740 Olfactory transduction 11/421 80/7206 0.00645708334785 ko04925 Aldosterone synthesis and secretion 13/421 105/7206 0.00957311625185 ko05168 Herpes simplex infection 3/421 182/7206 0.00961177067591 ko04973 Carbohydrate digestion and absorption 7/421 42/7206 0.0100690296856 ko05142 Chagas disease (American trypanosomiasis) 15/421 130/7206 0.0119806279855 ko04930 Type II diabetes mellitus 8/421 54/7206 0.0123711187821 ko04144 Endocytosis 31/421 342/7206 0.0128158937834 ko04072 Phospholipase D signaling pathway 20/421 197/7206 0.0133226218721 ko04971 Gastric acid secretion 12/421 98/7206 0.0139964278513 ko04070 Phosphatidylinositol signaling system 13/421 112/7206 0.0143486745676 ko04918 Thyroid hormone synthesis 11/421 86/7206 0.0164959641009 ko03013 RNA transport 3/421 166/7206 0.0184333888192 ko05164 Influenza A 3/421 167/7206 0.0184704292697 ko04060 Cytokine-cytokine receptor interaction 4/421 191/7206 0.0187136470162 ko04062 Chemokine signaling pathway 20/421 201/7206 0.0204512882407 ko00240 Pyrimidine metabolism 1/421 110/7206 0.0214954784511 ko04120 Ubiquitin mediated proteolysis 2/421 138/7206 0.0252255136416 ko04976 Bile secretion 10/421 80/7206 0.0253425398153 ko04080 Neuroactive ligand-receptor interaction 35/421 423/7206 0.0323975671207 ko05169 Epstein-Barr virus infection 5/421 206/7206 0.0333263784978 ko05205 Proteoglycans in cancer 8/421 271/7206 0.0345184552717 ko04130 SNARE interactions in vesicular transport 6/421 44/7206 0.041209430209 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/421 14/7206 0.0445288714375 ko05010 Alzheimer's disease 19/421 202/7206 0.0455526127184 ko04110 Cell cycle 3/421 145/7206 0.0480475886598