ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1199	423/7206	5.51545516795e-59
ko04724	Glutamatergic synapse	98/1199	152/7206	1.12413082812e-40
ko04713	Circadian entrainment	83/1199	136/7206	5.62500205583e-32
ko05032	Morphine addiction	73/1199	110/7206	1.03672845575e-31
ko05033	Nicotine addiction	49/1199	56/7206	2.0828804992e-31
ko04727	GABAergic synapse	71/1199	110/7206	1.0398514927e-29
ko04728	Dopaminergic synapse	92/1199	185/7206	5.09481048614e-26
ko04725	Cholinergic synapse	83/1199	160/7206	3.65358519545e-25
ko04723	Retrograde endocannabinoid signaling	82/1199	175/7206	3.7852337514e-21
ko04911	Insulin secretion	62/1199	117/7206	1.10947845631e-19
ko04721	Synaptic vesicle cycle	49/1199	80/7206	2.09410226962e-19
ko04024	cAMP signaling pathway	107/1199	279/7206	6.20089603234e-19
ko04020	Calcium signaling pathway	103/1199	265/7206	8.98257760346e-19
ko04726	Serotonergic synapse	66/1199	137/7206	5.10139378374e-18
ko04921	Oxytocin signaling pathway	82/1199	209/7206	2.70899852689e-15
ko05031	Amphetamine addiction	46/1199	91/7206	6.48667244388e-14
ko04742	Taste transduction	36/1199	61/7206	7.04400095533e-14
ko04744	Phototransduction	26/1199	36/7206	2.05380579216e-13
ko04970	Salivary secretion	46/1199	95/7206	4.90240769297e-13
ko04720	Long-term potentiation	47/1199	99/7206	6.84597253852e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1199	205/7206	2.67040752897e-12
ko04925	Aldosterone synthesis and secretion	46/1199	105/7206	4.0386876406e-11
ko03040	Spliceosome	1/1199	145/7206	1.18531342373e-10
ko04740	Olfactory transduction	37/1199	80/7206	5.08629229393e-10
ko04971	Gastric acid secretion	42/1199	98/7206	6.62797964615e-10
ko05030	Cocaine addiction	34/1199	73/7206	2.04782403679e-09
ko04010	MAPK signaling pathway	91/1199	321/7206	8.55791075084e-08
ko04022	cGMP-PKG signaling pathway	67/1199	216/7206	1.22893565421e-07
ko04972	Pancreatic secretion	41/1199	111/7206	2.06574127491e-07
ko04360	Axon guidance	70/1199	233/7206	2.32256364187e-07
ko05322	Systemic lupus erythematosus	5/1199	151/7206	3.8036787241e-07
ko05168	Herpes simplex infection	8/1199	182/7206	4.91241540896e-07
ko05203	Viral carcinogenesis	18/1199	277/7206	5.81531510128e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1199	74/7206	7.97413215429e-07
ko03013	RNA transport	7/1199	166/7206	1.29933506917e-06
ko04730	Long-term depression	31/1199	78/7206	1.50786296357e-06
ko04141	Protein processing in endoplasmic reticulum	10/1199	184/7206	4.97152548823e-06
ko04540	Gap junction	42/1199	128/7206	5.94270251243e-06
ko04060	Cytokine-cytokine receptor interaction	11/1199	191/7206	7.29573103807e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1199	59/7206	9.36575995021e-06
ko04070	Phosphatidylinositol signaling system	37/1199	112/7206	1.68263815908e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1199	122/7206	2.33134106056e-05
ko04745	Phototransduction - fly	17/1199	38/7206	4.43024755157e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1199	79/7206	4.61972535202e-05
ko05164	Influenza A	10/1199	167/7206	5.23846617291e-05
ko04976	Bile secretion	28/1199	80/7206	5.59255512687e-05
ko04072	Phospholipase D signaling pathway	55/1199	197/7206	5.80125166795e-05
ko04514	Cell adhesion molecules (CAMs)	40/1199	130/7206	6.52685107274e-05
ko04014	Ras signaling pathway	72/1199	279/7206	7.40181077977e-05
ko04371	Apelin signaling pathway	50/1199	177/7206	8.68824553393e-05
ko04924	Renin secretion	29/1199	86/7206	0.00010200930031
ko05414	Dilated cardiomyopathy	35/1199	112/7206	0.000103699292923
ko03008	Ribosome biogenesis in eukaryotes	2/1199	79/7206	0.000112065507923
ko04612	Antigen processing and presentation	2/1199	77/7206	0.00016629562457
ko04621	NOD-like receptor signaling pathway	10/1199	157/7206	0.000193185722473
ko04110	Cell cycle	9/1199	145/7206	0.000265348919764
ko04915	Estrogen signaling pathway	38/1199	131/7206	0.000333114376908
ko04260	Cardiac muscle contraction	30/1199	98/7206	0.000530583547614
ko04918	Thyroid hormone synthesis	27/1199	86/7206	0.000652802945639
ko04610	Complement and coagulation cascades	3/1199	79/7206	0.000696071179936
ko04120	Ubiquitin mediated proteolysis	9/1199	138/7206	0.000706948737185
ko04912	GnRH signaling pathway	35/1199	122/7206	0.000802884756021
ko04146	Peroxisome	4/1199	89/7206	0.000818054312136
ko05110	Vibrio cholerae infection	21/1199	63/7206	0.00100869524836
ko05169	Epstein-Barr virus infection	18/1199	206/7206	0.00119540306931
ko00590	Arachidonic acid metabolism	1/1199	52/7206	0.0012750249518
ko04923	Regulation of lipolysis in adipocytes	24/1199	77/7206	0.0016992255052
ko04966	Collecting duct acid secretion	11/1199	26/7206	0.0017570816603
ko04015	Rap1 signaling pathway	66/1199	278/7206	0.00176331541158
ko05162	Measles	8/1199	120/7206	0.00181350038058
ko00240	Pyrimidine metabolism	7/1199	110/7206	0.00183852749938
ko05205	Proteoglycans in cancer	27/1199	271/7206	0.00200595785844
ko00310	Lysine degradation	3/1199	73/7206	0.00222044812185
ko05144	Malaria	1/1199	45/7206	0.00434857450098
ko00071	Fatty acid degradation	1/1199	45/7206	0.00434857450098
ko03420	Nucleotide excision repair	1/1199	46/7206	0.0044317761631
ko03018	RNA degradation	5/1199	84/7206	0.00491385919819
ko04062	Chemokine signaling pathway	49/1199	201/7206	0.00508417229653
ko04960	Aldosterone-regulated sodium reabsorption	14/1199	41/7206	0.00535415639338
ko00480	Glutathione metabolism	2/1199	55/7206	0.00563380371801
ko05321	Inflammatory bowel disease (IBD)	2/1199	56/7206	0.00582624760917
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1199	182/7206	0.00623184177938
ko03022	Basal transcription factors	1/1199	44/7206	0.00681195647888
ko04115	p53 signaling pathway	4/1199	74/7206	0.00686212310177
ko04217	Necroptosis	17/1199	178/7206	0.00795436580351
ko04916	Melanogenesis	36/1199	142/7206	0.00836287299571
ko04630	Jak-STAT signaling pathway	11/1199	132/7206	0.00893097953273
ko04622	RIG-I-like receptor signaling pathway	3/1199	62/7206	0.00921356080166
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1199	100/7206	0.00942256713607
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1199	40/7206	0.00980977484374
ko00140	Steroid hormone biosynthesis	1/1199	41/7206	0.00998265590567
ko04973	Carbohydrate digestion and absorption	14/1199	42/7206	0.0105278271828
ko04064	NF-kappa B signaling pathway	7/1199	96/7206	0.0121908782093
ko04711	Circadian rhythm - fly	6/1199	13/7206	0.0124837873134
ko05161	Hepatitis B	17/1199	173/7206	0.0129198862562
ko05034	Alcoholism	54/1199	238/7206	0.0131187191973
ko00562	Inositol phosphate metabolism	24/1199	89/7206	0.0139174738492
ko00630	Glyoxylate and dicarboxylate metabolism	1/1199	38/7206	0.0147556031034
ko00982	Drug metabolism - cytochrome P450	1/1199	37/7206	0.0147647289585
ko05016	Huntington's disease	23/1199	215/7206	0.0155403543949
ko04930	Type II diabetes mellitus	16/1199	54/7206	0.0158485291294
ko04922	Glucagon signaling pathway	32/1199	128/7206	0.0158864200203
ko04270	Vascular smooth muscle contraction	37/1199	154/7206	0.0159654101249
ko00260	Glycine, serine and threonine metabolism	2/1199	48/7206	0.0177341388047
ko05140	Leishmaniasis	5/1199	75/7206	0.0182837166431
ko04213	Longevity regulating pathway - multiple species	23/1199	86/7206	0.0185457279738
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1199	14/7206	0.0188233051104
ko04964	Proximal tubule bicarbonate reclamation	10/1199	29/7206	0.0200756085773
ko04710	Circadian rhythm	13/1199	43/7206	0.0229807291726
ko05418	Fluid shear stress and atherosclerosis	18/1199	173/7206	0.0230546139414
ko04214	Apoptosis - fly	5/1199	72/7206	0.0249393390441
ko04330	Notch signaling pathway	4/1199	62/7206	0.0259056038113
ko00280	Valine, leucine and isoleucine degradation	3/1199	54/7206	0.0263188534217
ko04142	Lysosome	15/1199	151/7206	0.0265140445957
ko04640	Hematopoietic cell lineage	4/1199	64/7206	0.0265614819702
ko04658	Th1 and Th2 cell differentiation	8/1199	96/7206	0.0265970018236
ko04114	Oocyte meiosis	33/1199	139/7206	0.0284400602734
ko04657	IL-17 signaling pathway	7/1199	87/7206	0.0291051934171
ko05133	Pertussis	7/1199	87/7206	0.0291051934171
ko05145	Toxoplasmosis	12/1199	126/7206	0.0294204322846
ko03320	PPAR signaling pathway	5/1199	69/7206	0.0339496518474
ko05231	Choline metabolism in cancer	32/1199	134/7206	0.0340832925214
ko00330	Arginine and proline metabolism	4/1199	61/7206	0.0363825216092
ko00983	Drug metabolism - other enzymes	2/1199	42/7206	0.0364103488325
ko00230	Purine metabolism	43/1199	194/7206	0.040088865162
ko04620	Toll-like receptor signaling pathway	9/1199	100/7206	0.0415199095356
ko04071	Sphingolipid signaling pathway	37/1199	162/7206	0.0417929044241
ko04210	Apoptosis	20/1199	180/7206	0.042685506577
ko05166	HTLV-I infection	36/1199	292/7206	0.0447202927538
ko00512	Mucin type O-glycan biosynthesis	9/1199	29/7206	0.0456451036342
ko05202	Transcriptional misregulation in cancer	21/1199	188/7206	0.0464896782246
ko05214	Glioma	20/1199	79/7206	0.0469985112843