ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1267	423/7206	1.43211327558e-54
ko04724	Glutamatergic synapse	92/1267	152/7206	5.84992609345e-33
ko04713	Circadian entrainment	80/1267	136/7206	1.45396916688e-27
ko05033	Nicotine addiction	47/1267	56/7206	2.36992497499e-27
ko05032	Morphine addiction	70/1267	110/7206	3.33005268588e-27
ko04727	GABAergic synapse	68/1267	110/7206	2.28653823893e-25
ko04725	Cholinergic synapse	81/1267	160/7206	4.79152183381e-22
ko04728	Dopaminergic synapse	88/1267	185/7206	1.74097279725e-21
ko04721	Synaptic vesicle cycle	50/1267	80/7206	2.965827858e-19
ko04020	Calcium signaling pathway	106/1267	265/7206	2.19232269755e-18
ko04723	Retrograde endocannabinoid signaling	80/1267	175/7206	2.61793709238e-18
ko04024	cAMP signaling pathway	108/1267	279/7206	1.30070669974e-17
ko04911	Insulin secretion	60/1267	117/7206	5.73057646883e-17
ko04742	Taste transduction	39/1267	61/7206	8.8105744929e-16
ko04726	Serotonergic synapse	64/1267	137/7206	1.91766123041e-15
ko04921	Oxytocin signaling pathway	83/1267	209/7206	1.73947868121e-14
ko04970	Salivary secretion	46/1267	95/7206	3.7801620533e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1267	205/7206	4.19121288437e-11
ko05031	Amphetamine addiction	42/1267	91/7206	2.27249265993e-10
ko03040	Spliceosome	2/1267	145/7206	3.72353392221e-10
ko04720	Long-term potentiation	44/1267	99/7206	3.87664286736e-10
ko04744	Phototransduction	23/1267	36/7206	8.04662010268e-10
ko04925	Aldosterone synthesis and secretion	45/1267	105/7206	1.0432324012e-09
ko04971	Gastric acid secretion	42/1267	98/7206	3.77355813082e-09
ko04740	Olfactory transduction	36/1267	80/7206	1.03026602138e-08
ko04022	cGMP-PKG signaling pathway	71/1267	216/7206	3.0854449979e-08
ko05203	Viral carcinogenesis	18/1267	277/7206	7.25685146395e-08
ko04360	Axon guidance	74/1267	233/7206	9.56730961879e-08
ko05322	Systemic lupus erythematosus	5/1267	151/7206	1.05500015136e-07
ko03013	RNA transport	7/1267	166/7206	2.50811534708e-07
ko05168	Herpes simplex infection	9/1267	182/7206	5.08204926673e-07
ko04014	Ras signaling pathway	81/1267	279/7206	1.72210529188e-06
ko04730	Long-term depression	31/1267	78/7206	3.2379836082e-06
ko04972	Pancreatic secretion	40/1267	111/7206	3.28054044773e-06
ko04010	MAPK signaling pathway	89/1267	321/7206	3.99964221083e-06
ko05030	Cocaine addiction	29/1267	73/7206	6.94049179369e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1267	74/7206	9.14784276394e-06
ko04540	Gap junction	43/1267	128/7206	9.97259483054e-06
ko04072	Phospholipase D signaling pathway	59/1267	197/7206	1.56469589192e-05
ko04621	NOD-like receptor signaling pathway	9/1267	157/7206	1.6871297007e-05
ko04060	Cytokine-cytokine receptor interaction	13/1267	191/7206	1.81842797611e-05
ko04514	Cell adhesion molecules (CAMs)	43/1267	130/7206	1.96550419744e-05
ko04966	Collecting duct acid secretion	14/1267	26/7206	2.95013771467e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1267	122/7206	3.61284870771e-05
ko04141	Protein processing in endoplasmic reticulum	13/1267	184/7206	4.76057062698e-05
ko05164	Influenza A	11/1267	167/7206	4.8778567549e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1267	79/7206	7.12523853441e-05
ko04070	Phosphatidylinositol signaling system	37/1267	112/7206	7.63247514624e-05
ko04976	Bile secretion	29/1267	80/7206	7.72950396948e-05
ko04745	Phototransduction - fly	17/1267	38/7206	9.13873811634e-05
ko04924	Renin secretion	30/1267	86/7206	9.2761749846e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1267	79/7206	0.000137090634723
ko04371	Apelin signaling pathway	51/1267	177/7206	0.00018876998046
ko04110	Cell cycle	10/1267	145/7206	0.000243366868331
ko04120	Ubiquitin mediated proteolysis	9/1267	138/7206	0.000251631005839
ko05110	Vibrio cholerae infection	23/1267	63/7206	0.000324632545803
ko05414	Dilated cardiomyopathy	35/1267	112/7206	0.000380196156424
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1267	59/7206	0.00038728743127
ko04964	Proximal tubule bicarbonate reclamation	13/1267	29/7206	0.00060019090581
ko05140	Leishmaniasis	3/1267	75/7206	0.000652745836464
ko04260	Cardiac muscle contraction	31/1267	98/7206	0.00068743591453
ko04923	Regulation of lipolysis in adipocytes	26/1267	77/7206	0.000712581723187
ko04916	Melanogenesis	41/1267	142/7206	0.000759759593678
ko04270	Vascular smooth muscle contraction	44/1267	154/7206	0.0008060756404
ko04915	Estrogen signaling pathway	38/1267	131/7206	0.0010771548773
ko04064	NF-kappa B signaling pathway	6/1267	96/7206	0.00173226278759
ko04146	Peroxisome	5/1267	89/7206	0.00174428173613
ko04015	Rap1 signaling pathway	69/1267	278/7206	0.00216022582296
ko04612	Antigen processing and presentation	4/1267	77/7206	0.00226330409765
ko00071	Fatty acid degradation	1/1267	45/7206	0.00274215545943
ko03420	Nucleotide excision repair	1/1267	46/7206	0.00280301913637
ko04217	Necroptosis	17/1267	178/7206	0.00361993256358
ko05169	Epstein-Barr virus infection	21/1267	206/7206	0.00382428184264
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1267	182/7206	0.0041521618817
ko03022	Basal transcription factors	1/1267	44/7206	0.00431298745353
ko00310	Lysine degradation	4/1267	73/7206	0.00472182735059
ko05162	Measles	10/1267	120/7206	0.00519324352599
ko00330	Arginine and proline metabolism	3/1267	61/7206	0.00613615000304
ko04622	RIG-I-like receptor signaling pathway	3/1267	62/7206	0.00636325807609
ko04657	IL-17 signaling pathway	6/1267	87/7206	0.00652180273005
ko05133	Pertussis	6/1267	87/7206	0.00652180273005
ko04610	Complement and coagulation cascades	5/1267	79/7206	0.00672724832209
ko04710	Circadian rhythm	15/1267	43/7206	0.00728770991275
ko04626	Plant-pathogen interaction	8/1267	18/7206	0.00738615949253
ko04912	GnRH signaling pathway	33/1267	122/7206	0.00804868735232
ko03018	RNA degradation	6/1267	84/7206	0.00890985393307
ko03410	Base excision repair	1/1267	38/7206	0.00942025582204
ko05161	Hepatitis B	18/1267	173/7206	0.011141013444
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1267	100/7206	0.0111647167275
ko04930	Type II diabetes mellitus	17/1267	54/7206	0.0112303242222
ko04960	Aldosterone-regulated sodium reabsorption	14/1267	41/7206	0.0113696829909
ko05131	Shigellosis	6/1267	82/7206	0.0123076070816
ko04214	Apoptosis - fly	5/1267	72/7206	0.0126888644283
ko04973	Carbohydrate digestion and absorption	14/1267	42/7206	0.0129054620219
ko01200	Carbon metabolism	12/1267	128/7206	0.0132931087225
ko04658	Th1 and Th2 cell differentiation	8/1267	96/7206	0.0145277762273
ko04918	Thyroid hormone synthesis	24/1267	86/7206	0.0151464118112
ko00240	Pyrimidine metabolism	10/1267	110/7206	0.0160937923799
ko05016	Huntington's disease	25/1267	215/7206	0.0179640120893
ko05205	Proteoglycans in cancer	33/1267	271/7206	0.0180052693608
ko00280	Valine, leucine and isoleucine degradation	3/1267	54/7206	0.0181274756798
ko05231	Choline metabolism in cancer	34/1267	134/7206	0.0215000064876
ko00500	Starch and sucrose metabolism	1/1267	35/7206	0.0226710535762
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1267	14/7206	0.0243686411468
ko03320	PPAR signaling pathway	5/1267	69/7206	0.0245783136117
ko00380	Tryptophan metabolism	3/1267	50/7206	0.0254382963554
ko00590	Arachidonic acid metabolism	3/1267	52/7206	0.0261097069837
ko04213	Longevity regulating pathway - multiple species	23/1267	86/7206	0.0317037134248
ko04922	Glucagon signaling pathway	32/1267	128/7206	0.0341121311759
ko05321	Inflammatory bowel disease (IBD)	4/1267	56/7206	0.0349346374917
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1267	40/7206	0.0355001587873
ko00260	Glycine, serine and threonine metabolism	3/1267	48/7206	0.0358921558788
ko05219	Bladder cancer	3/1267	48/7206	0.0358921558788
ko04630	Jak-STAT signaling pathway	14/1267	132/7206	0.0369282329509
ko04620	Toll-like receptor signaling pathway	10/1267	100/7206	0.0466125797404
ko00480	Glutathione metabolism	4/1267	55/7206	0.048613595937
ko00562	Inositol phosphate metabolism	23/1267	89/7206	0.048726442221