ko pathway ratio_in_study ratio_in_pop p_value ko03440 Homologous recombination 22/394 41/7206 9.02534224063e-18 ko03460 Fanconi anemia pathway 21/394 51/7206 4.64705424982e-14 ko05322 Systemic lupus erythematosus 35/394 151/7206 1.11399109593e-13 ko03013 RNA transport 36/394 166/7206 4.23381127257e-13 ko04110 Cell cycle 33/394 145/7206 1.01005731573e-12 ko03040 Spliceosome 30/394 145/7206 1.44409238428e-10 ko04111 Cell cycle - yeast 23/394 90/7206 2.62449210738e-10 ko05203 Viral carcinogenesis 42/394 277/7206 9.70561528028e-10 ko05034 Alcoholism 37/394 238/7206 5.1612493876e-09 ko03008 Ribosome biogenesis in eukaryotes 19/394 79/7206 2.87843888425e-08 ko03022 Basal transcription factors 14/394 44/7206 4.32536322074e-08 ko04113 Meiosis - yeast 16/394 70/7206 7.66723507534e-07 ko03018 RNA degradation 17/394 84/7206 2.1412601273e-06 ko04144 Endocytosis 3/394 342/7206 7.96529521213e-06 ko03410 Base excision repair 10/394 38/7206 2.53153633477e-05 ko04024 cAMP signaling pathway 2/394 279/7206 3.71715853448e-05 ko04151 PI3K-Akt signaling pathway 6/394 390/7206 8.41801337478e-05 ko03450 Non-homologous end-joining 6/394 15/7206 8.44020853787e-05 ko04914 Progesterone-mediated oocyte maturation 16/394 104/7206 0.000147843561465 ko05010 Alzheimer's disease 1/394 202/7206 0.000226386958392 ko04510 Focal adhesion 2/394 240/7206 0.00023589709556 ko00240 Pyrimidine metabolism 16/394 110/7206 0.000287703558199 ko04114 Oocyte meiosis 18/394 139/7206 0.000530062260053 ko04022 cGMP-PKG signaling pathway 2/394 216/7206 0.000707574135206 ko03420 Nucleotide excision repair 9/394 46/7206 0.000721115979559 ko03020 RNA polymerase 7/394 29/7206 0.00075705285151 ko03030 DNA replication 8/394 38/7206 0.000853655463314 ko04261 Adrenergic signaling in cardiomyocytes 2/394 205/7206 0.00149286241376 ko04724 Glutamatergic synapse 1/394 152/7206 0.00329359512288 ko04728 Dopaminergic synapse 2/394 185/7206 0.00450060211614 ko04921 Oxytocin signaling pathway 3/394 209/7206 0.0049542173099 ko05200 Pathways in cancer 14/394 492/7206 0.00544989447456 ko04810 Regulation of actin cytoskeleton 5/394 264/7206 0.00546154866891 ko04723 Retrograde endocannabinoid signaling 2/394 175/7206 0.00619348936149 ko04713 Circadian entrainment 1/394 136/7206 0.00693018768565 ko04015 Rap1 signaling pathway 6/394 278/7206 0.00994685064041 ko01200 Carbon metabolism 1/394 128/7206 0.010052743544 ko04218 Cellular senescence 18/394 177/7206 0.0106573639224 ko04010 MAPK signaling pathway 8/394 321/7206 0.011856540468 ko04621 NOD-like receptor signaling pathway 2/394 157/7206 0.0122635875132 ko04611 Platelet activation 2/394 163/7206 0.0129191162247 ko05205 Proteoglycans in cancer 6/394 271/7206 0.0133865918762 ko05152 Tuberculosis 3/394 187/7206 0.0134800175187 ko04390 Hippo signaling pathway 3/394 188/7206 0.0135632062905 ko04668 TNF signaling pathway 1/394 120/7206 0.014575689297 ko04750 Inflammatory mediator regulation of TRP channels 1/394 122/7206 0.0146149364974 ko04666 Fc gamma R-mediated phagocytosis 1/394 122/7206 0.0146149364974 ko04066 HIF-1 signaling pathway 1/394 123/7206 0.0147045067311 ko00190 Oxidative phosphorylation 1/394 127/7206 0.0155342805845 ko04371 Apelin signaling pathway 3/394 177/7206 0.018566587406 ko04115 p53 signaling pathway 9/394 74/7206 0.0188431946944 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/394 182/7206 0.0190492387023 ko04911 Insulin secretion 1/394 117/7206 0.0215425120866 ko04014 Ras signaling pathway 7/394 279/7206 0.0220419519079 ko04072 Phospholipase D signaling pathway 4/394 197/7206 0.0256043095294 ko04062 Chemokine signaling pathway 4/394 201/7206 0.0259740844585 ko03430 Mismatch repair 4/394 22/7206 0.0294160058013 ko04727 GABAergic synapse 1/394 110/7206 0.0312149578269 ko05032 Morphine addiction 1/394 110/7206 0.0312149578269 ko04070 Phosphatidylinositol signaling system 1/394 112/7206 0.032150497737 ko03015 mRNA surveillance pathway 10/394 93/7206 0.0350988054976 ko04152 AMPK signaling pathway 3/394 161/7206 0.0352659277321 ko04971 Gastric acid secretion 1/394 98/7206 0.0438045296914 ko05166 HTLV-I infection 24/394 292/7206 0.0470339185233 ko05145 Toxoplasmosis 2/394 126/7206 0.0478805815803 ko04922 Glucagon signaling pathway 2/394 128/7206 0.048026326426 ko05012 Parkinson's disease 3/394 155/7206 0.0483379100416 ko05142 Chagas disease (American trypanosomiasis) 2/394 130/7206 0.0485778959152 ko04725 Cholinergic synapse 3/394 160/7206 0.0498691317693