ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko00190	Oxidative phosphorylation	58/949	127/7206	1.61030900214e-19
ko04723	Retrograde endocannabinoid signaling	70/949	175/7206	2.4112549079e-19
ko04080	Neuroactive ligand-receptor interaction	123/949	423/7206	6.38809611976e-19
ko04260	Cardiac muscle contraction	46/949	98/7206	2.67948001274e-16
ko05010	Alzheimer's disease	71/949	202/7206	5.09189640087e-16
ko05012	Parkinson's disease	56/949	155/7206	1.88228976024e-13
ko04911	Insulin secretion	47/949	117/7206	1.89364057687e-13
ko05033	Nicotine addiction	30/949	56/7206	5.51147484834e-13
ko04724	Glutamatergic synapse	53/949	152/7206	4.27757194641e-12
ko04713	Circadian entrainment	49/949	136/7206	7.12548939006e-12
ko04921	Oxytocin signaling pathway	65/949	209/7206	9.16150617599e-12
ko04020	Calcium signaling pathway	76/949	265/7206	1.21904585867e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/949	205/7206	2.83195278734e-11
ko05410	Hypertrophic cardiomyopathy (HCM)	38/949	100/7206	2.82470004712e-10
ko04721	Synaptic vesicle cycle	32/949	80/7206	1.62091388372e-09
ko04727	GABAergic synapse	38/949	110/7206	6.57746844892e-09
ko04964	Proximal tubule bicarbonate reclamation	17/949	29/7206	1.03291639835e-08
ko04970	Salivary secretion	34/949	95/7206	1.48903542059e-08
ko04022	cGMP-PKG signaling pathway	59/949	216/7206	1.71292469973e-08
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	30/949	79/7206	2.20325191025e-08
ko05032	Morphine addiction	37/949	110/7206	2.35732596048e-08
ko04971	Gastric acid secretion	34/949	98/7206	3.65645097399e-08
ko03040	Spliceosome	1/949	145/7206	3.66099552126e-08
ko04725	Cholinergic synapse	47/949	160/7206	4.37977654361e-08
ko01200	Carbon metabolism	40/949	128/7206	7.76405839337e-08
ko04060	Cytokine-cytokine receptor interaction	4/949	191/7206	9.48791627791e-08
ko05414	Dilated cardiomyopathy	36/949	112/7206	1.35840574876e-07
ko04550	Signaling pathways regulating pluripotency of stem cells	3/949	165/7206	2.9284194439e-07
ko05168	Herpes simplex infection	4/949	182/7206	3.05884172009e-07
ko04976	Bile secretion	28/949	80/7206	4.77107628209e-07
ko04932	Non-alcoholic fatty liver disease (NAFLD)	49/949	182/7206	5.60876840674e-07
ko05016	Huntington's disease	55/949	215/7206	5.930450883e-07
ko04978	Mineral absorption	18/949	40/7206	7.92410839029e-07
ko04974	Protein digestion and absorption	31/949	96/7206	8.98676634051e-07
ko05203	Viral carcinogenesis	12/949	277/7206	1.10587311629e-06
ko04742	Taste transduction	23/949	61/7206	1.13076383441e-06
ko04120	Ubiquitin mediated proteolysis	2/949	138/7206	1.31976465891e-06
ko04728	Dopaminergic synapse	48/949	185/7206	2.33881668319e-06
ko04972	Pancreatic secretion	33/949	111/7206	3.35748190605e-06
ko05164	Influenza A	5/949	167/7206	7.89046659497e-06
ko05031	Amphetamine addiction	28/949	91/7206	1.10361128197e-05
ko04024	cAMP signaling pathway	63/949	279/7206	1.16189814288e-05
ko03013	RNA transport	5/949	166/7206	1.17570439164e-05
ko04924	Renin secretion	26/949	86/7206	3.03296684903e-05
ko05322	Systemic lupus erythematosus	5/949	151/7206	4.80526228441e-05
ko00020	Citrate cycle (TCA cycle)	14/949	35/7206	6.76648291758e-05
ko04270	Vascular smooth muscle contraction	38/949	154/7206	9.01975687168e-05
ko04726	Serotonergic synapse	35/949	137/7206	9.39429808318e-05
ko04110	Cell cycle	5/949	145/7206	9.76491403733e-05
ko05162	Measles	3/949	120/7206	9.78256888141e-05
ko00010	Glycolysis / Gluconeogenesis	22/949	74/7206	0.00016570304009
ko04745	Phototransduction - fly	14/949	38/7206	0.000192371503973
ko00680	Methane metabolism	13/949	34/7206	0.000211137590961
ko05161	Hepatitis B	8/949	173/7206	0.000241077091618
ko05166	HTLV-I infection	19/949	292/7206	0.000269765125058
ko03008	Ribosome biogenesis in eukaryotes	1/949	79/7206	0.000315490789328
ko05169	Epstein-Barr virus infection	11/949	206/7206	0.00033012640607
ko00710	Carbon fixation in photosynthetic organisms	11/949	27/7206	0.000339320211089
ko04371	Apelin signaling pathway	40/949	177/7206	0.000438412932624
ko04621	NOD-like receptor signaling pathway	7/949	157/7206	0.000455876750309
ko00620	Pyruvate metabolism	15/949	46/7206	0.000532941031341
ko01230	Biosynthesis of amino acids	23/949	85/7206	0.000535184166858
ko04922	Glucagon signaling pathway	31/949	128/7206	0.000535642761648
ko04350	TGF-beta signaling pathway	3/949	103/7206	0.000605692770325
ko04740	Olfactory transduction	22/949	80/7206	0.000625461388023
ko04140	Autophagy - animal	8/949	164/7206	0.000629168993764
ko04657	IL-17 signaling pathway	2/949	87/7206	0.000689638994008
ko04514	Cell adhesion molecules (CAMs)	31/949	130/7206	0.000888828799628
ko04730	Long-term depression	21/949	78/7206	0.00105325497873
ko04210	Apoptosis	10/949	180/7206	0.00111733005128
ko04925	Aldosterone synthesis and secretion	26/949	105/7206	0.00115071368507
ko04144	Endocytosis	26/949	342/7206	0.00132130924124
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/949	59/7206	0.00138008255206
ko05206	MicroRNAs in cancer	10/949	177/7206	0.00150392126529
ko04668	TNF signaling pathway	5/949	120/7206	0.00154453214968
ko04630	Jak-STAT signaling pathway	6/949	132/7206	0.00161351948046
ko04142	Lysosome	8/949	151/7206	0.00217997492562
ko04720	Long-term potentiation	24/949	99/7206	0.00240807529567
ko05014	Amyotrophic lateral sclerosis (ALS)	19/949	74/7206	0.00302884265586
ko00362	Benzoate degradation	4/949	6/7206	0.00359674002136
ko04620	Toll-like receptor signaling pathway	4/949	100/7206	0.00409693811896
ko04390	Hippo signaling pathway	12/949	188/7206	0.00418897578999
ko05215	Prostate cancer	5/949	111/7206	0.00420552146909
ko04214	Apoptosis - fly	2/949	72/7206	0.00453627955483
ko05212	Pancreatic cancer	3/949	83/7206	0.00522871679568
ko05220	Chronic myeloid leukemia	3/949	85/7206	0.00533459214475
ko04141	Protein processing in endoplasmic reticulum	12/949	184/7206	0.00543949612853
ko04658	Th1 and Th2 cell differentiation	4/949	96/7206	0.00565113761184
ko04064	NF-kappa B signaling pathway	4/949	96/7206	0.00565113761184
ko05217	Basal cell carcinoma	2/949	68/7206	0.00657775807637
ko05030	Cocaine addiction	18/949	73/7206	0.00780381767473
ko04914	Progesterone-mediated oocyte maturation	5/949	104/7206	0.00797139685836
ko05321	Inflammatory bowel disease (IBD)	1/949	56/7206	0.00816323061821
ko04960	Aldosterone-regulated sodium reabsorption	12/949	41/7206	0.00816795770981
ko00290	Valine, leucine and isoleucine biosynthesis	3/949	4/7206	0.00821387336774
ko00260	Glycine, serine and threonine metabolism	13/949	48/7206	0.00864482470788
ko01522	Endocrine resistance	7/949	124/7206	0.0102636953283
ko04612	Antigen processing and presentation	3/949	77/7206	0.0104988994789
ko04010	MAPK signaling pathway	58/949	321/7206	0.0110303846937
ko00250	Alanine, aspartate and glutamate metabolism	11/949	38/7206	0.0125784754687
ko00630	Glyoxylate and dicarboxylate metabolism	11/949	38/7206	0.0125784754687
ko00071	Fatty acid degradation	12/949	45/7206	0.0131395215909
ko04622	RIG-I-like receptor signaling pathway	2/949	62/7206	0.0136643663738
ko05140	Leishmaniasis	3/949	75/7206	0.0149825474545
ko05132	Salmonella infection	5/949	98/7206	0.0151004303556
ko04966	Collecting duct acid secretion	8/949	26/7206	0.0154358678257
ko04212	Longevity regulating pathway - worm	4/949	87/7206	0.015445788821
ko05219	Bladder cancer	1/949	48/7206	0.0167976276158
ko00380	Tryptophan metabolism	13/949	50/7206	0.0180250845084
ko05200	Pathways in cancer	48/949	492/7206	0.0188348476918
ko04977	Vitamin digestion and absorption	7/949	22/7206	0.0190967128372
ko04659	Th17 cell differentiation	6/949	106/7206	0.0195892355929
ko00830	Retinol metabolism	11/949	42/7206	0.0199542460254
ko04973	Carbohydrate digestion and absorption	11/949	42/7206	0.0199542460254
ko04150	mTOR signaling pathway	14/949	184/7206	0.0203836913317
ko04933	AGE-RAGE signaling pathway in diabetic complications	9/949	135/7206	0.0205190128817
ko04113	Meiosis - yeast	3/949	70/7206	0.0208552436257
ko04137	Mitophagy - animal	4/949	82/7206	0.0209360208615
ko04660	T cell receptor signaling pathway	8/949	124/7206	0.0223948226899
ko04626	Plant-pathogen interaction	6/949	18/7206	0.023411763267
ko03420	Nucleotide excision repair	1/949	46/7206	0.025529333739
ko00030	Pentose phosphate pathway	9/949	32/7206	0.0299103703835
ko01212	Fatty acid metabolism	14/949	60/7206	0.0319669267291
ko04217	Necroptosis	14/949	178/7206	0.0326555164861
ko00350	Tyrosine metabolism	9/949	33/7206	0.0326748924064
ko05110	Vibrio cholerae infection	14/949	63/7206	0.0394355843561
ko04011	MAPK signaling pathway - yeast	2/949	53/7206	0.0401667002976
ko01521	EGFR tyrosine kinase inhibitor resistance	7/949	106/7206	0.0424427952796
ko05145	Toxoplasmosis	9/949	126/7206	0.0453004165279
ko04540	Gap junction	25/949	128/7206	0.0463702847947