ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	176/1080	423/7206	4.91166716659e-43
ko04724	Glutamatergic synapse	82/1080	152/7206	1.13467397647e-29
ko05033	Nicotine addiction	44/1080	56/7206	2.26750871894e-26
ko05032	Morphine addiction	63/1080	110/7206	6.16079674666e-25
ko04721	Synaptic vesicle cycle	51/1080	80/7206	2.08379708471e-23
ko04727	GABAergic synapse	61/1080	110/7206	3.68432427294e-23
ko04713	Circadian entrainment	68/1080	136/7206	2.92029112025e-22
ko04728	Dopaminergic synapse	80/1080	185/7206	6.71874644042e-21
ko04725	Cholinergic synapse	73/1080	160/7206	8.15216616873e-21
ko04723	Retrograde endocannabinoid signaling	74/1080	175/7206	1.00458992973e-18
ko04024	cAMP signaling pathway	93/1080	279/7206	6.37246493516e-15
ko04911	Insulin secretion	52/1080	117/7206	1.41806481419e-14
ko04742	Taste transduction	35/1080	61/7206	2.01934359578e-14
ko04020	Calcium signaling pathway	87/1080	265/7206	1.08084670365e-13
ko04921	Oxytocin signaling pathway	74/1080	209/7206	1.32106125967e-13
ko04726	Serotonergic synapse	54/1080	137/7206	1.74439599471e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1080	205/7206	4.73309751038e-12
ko05031	Amphetamine addiction	38/1080	91/7206	5.00336255906e-10
ko04970	Salivary secretion	39/1080	95/7206	5.41721258269e-10
ko04720	Long-term potentiation	40/1080	99/7206	5.76262403915e-10
ko03040	Spliceosome	1/1080	145/7206	2.18456562685e-09
ko04744	Phototransduction	21/1080	36/7206	2.38581969652e-09
ko04360	Axon guidance	70/1080	233/7206	3.18398752792e-09
ko04971	Gastric acid secretion	36/1080	98/7206	7.98228471772e-08
ko05168	Herpes simplex infection	6/1080	182/7206	4.37954347939e-07
ko05164	Influenza A	5/1080	167/7206	4.73024204028e-07
ko04060	Cytokine-cytokine receptor interaction	7/1080	191/7206	5.13380365578e-07
ko04966	Collecting duct acid secretion	15/1080	26/7206	5.96739938985e-07
ko04925	Aldosterone synthesis and secretion	36/1080	105/7206	6.13754754862e-07
ko05203	Viral carcinogenesis	15/1080	277/7206	7.11807537448e-07
ko04540	Gap junction	40/1080	128/7206	2.34870471553e-06
ko03013	RNA transport	6/1080	166/7206	2.65153442727e-06
ko04022	cGMP-PKG signaling pathway	58/1080	216/7206	4.18553400706e-06
ko04120	Ubiquitin mediated proteolysis	4/1080	138/7206	5.21720186393e-06
ko04740	Olfactory transduction	28/1080	80/7206	8.6927751753e-06
ko05030	Cocaine addiction	26/1080	73/7206	1.64154206767e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1080	79/7206	1.83203153854e-05
ko04141	Protein processing in endoplasmic reticulum	9/1080	184/7206	2.18873493905e-05
ko05322	Systemic lupus erythematosus	6/1080	151/7206	2.40311726586e-05
ko04010	MAPK signaling pathway	76/1080	321/7206	2.76146655706e-05
ko04621	NOD-like receptor signaling pathway	7/1080	157/7206	3.69999451088e-05
ko05414	Dilated cardiomyopathy	34/1080	112/7206	4.09630326226e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1080	74/7206	4.61757915411e-05
ko04745	Phototransduction - fly	16/1080	38/7206	4.92783847841e-05
ko04972	Pancreatic secretion	33/1080	111/7206	7.00227194098e-05
ko04070	Phosphatidylinositol signaling system	33/1080	112/7206	7.86398538767e-05
ko04924	Renin secretion	27/1080	86/7206	9.9527157566e-05
ko05169	Epstein-Barr virus infection	13/1080	206/7206	0.000147611782656
ko04730	Long-term depression	25/1080	78/7206	0.000151860218782
ko05110	Vibrio cholerae infection	21/1080	63/7206	0.000238900509481
ko04064	NF-kappa B signaling pathway	3/1080	96/7206	0.000253565332452
ko04260	Cardiac muscle contraction	29/1080	98/7206	0.000270260315112
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1080	14/7206	0.000320331435108
ko05205	Proteoglycans in cancer	21/1080	271/7206	0.000347403104275
ko04514	Cell adhesion molecules (CAMs)	35/1080	130/7206	0.000421812959746
ko03008	Ribosome biogenesis in eukaryotes	2/1080	79/7206	0.000648780199025
ko04976	Bile secretion	24/1080	80/7206	0.000696091163523
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1080	59/7206	0.000727932741107
ko05161	Hepatitis B	11/1080	173/7206	0.000734322282226
ko04072	Phospholipase D signaling pathway	47/1080	197/7206	0.000791794868468
ko05140	Leishmaniasis	2/1080	75/7206	0.000908725192792
ko05162	Measles	6/1080	120/7206	0.00107471611351
ko04014	Ras signaling pathway	62/1080	279/7206	0.00107920661562
ko04915	Estrogen signaling pathway	34/1080	131/7206	0.001134435305
ko04964	Proximal tubule bicarbonate reclamation	11/1080	29/7206	0.00209079746504
ko00480	Glutathione metabolism	1/1080	55/7206	0.00210938915751
ko04146	Peroxisome	4/1080	89/7206	0.00259135036129
ko04626	Plant-pathogen interaction	8/1080	18/7206	0.00266859559955
ko04668	TNF signaling pathway	7/1080	120/7206	0.00277042448796
ko04750	Inflammatory mediator regulation of TRP channels	31/1080	122/7206	0.00289899969032
ko01524	Platinum drug resistance	3/1080	76/7206	0.00335392195401
ko04612	Antigen processing and presentation	3/1080	77/7206	0.00337711766706
ko04371	Apelin signaling pathway	41/1080	177/7206	0.00373076870251
ko04640	Hematopoietic cell lineage	2/1080	64/7206	0.0041968431218
ko04110	Cell cycle	10/1080	145/7206	0.00445223134357
ko00590	Arachidonic acid metabolism	1/1080	52/7206	0.00505709659858
ko00330	Arginine and proline metabolism	2/1080	61/7206	0.00608995187242
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1080	100/7206	0.00717568018662
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1080	182/7206	0.00824487779587
ko04916	Melanogenesis	33/1080	142/7206	0.00853228717456
ko00240	Pyrimidine metabolism	7/1080	110/7206	0.00976530484966
ko04912	GnRH signaling pathway	29/1080	122/7206	0.00989927887449
ko04923	Regulation of lipolysis in adipocytes	20/1080	77/7206	0.00995761622452
ko03022	Basal transcription factors	1/1080	44/7206	0.0105251688272
ko05144	Malaria	1/1080	45/7206	0.0105714641265
ko00071	Fatty acid degradation	1/1080	45/7206	0.0105714641265
ko03420	Nucleotide excision repair	1/1080	46/7206	0.0109246968419
ko05145	Toxoplasmosis	9/1080	126/7206	0.0111961294545
ko05321	Inflammatory bowel disease (IBD)	2/1080	56/7206	0.0130068321913
ko04630	Jak-STAT signaling pathway	10/1080	132/7206	0.0134649423501
ko04270	Vascular smooth muscle contraction	34/1080	154/7206	0.016293904895
ko04391	Hippo signaling pathway - fly	22/1080	90/7206	0.0166137196759
ko05131	Shigellosis	5/1080	82/7206	0.0191842254329
ko00280	Valine, leucine and isoleucine degradation	2/1080	54/7206	0.0193472611385
ko04622	RIG-I-like receptor signaling pathway	3/1080	62/7206	0.019594556594
ko03018	RNA degradation	5/1080	84/7206	0.0196948104332
ko04214	Apoptosis - fly	4/1080	72/7206	0.0197097487759
ko00310	Lysine degradation	4/1080	73/7206	0.0198520476321
ko04620	Toll-like receptor signaling pathway	7/1080	100/7206	0.0230761073111
ko01200	Carbon metabolism	10/1080	128/7206	0.0235160849854
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1080	40/7206	0.0236792880229
ko05206	MicroRNAs in cancer	16/1080	177/7206	0.0246231538456
ko00140	Steroid hormone biosynthesis	1/1080	41/7206	0.0247359887623
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1080	92/7206	0.0259233698071
ko00380	Tryptophan metabolism	2/1080	50/7206	0.02681983099
ko04670	Leukocyte transendothelial migration	13/1080	151/7206	0.0277807556981
ko04658	Th1 and Th2 cell differentiation	7/1080	96/7206	0.0305503509236
ko05418	Fluid shear stress and atherosclerosis	16/1080	173/7206	0.0308343582939
ko05133	Pertussis	6/1080	87/7206	0.0332991160682
ko04210	Apoptosis	17/1080	180/7206	0.0341367821697
ko04145	Phagosome	34/1080	162/7206	0.0344027025975
ko00982	Drug metabolism - cytochrome P450	1/1080	37/7206	0.0348677666789
ko04140	Autophagy - animal	15/1080	164/7206	0.0348988744448
ko04350	TGF-beta signaling pathway	8/1080	103/7206	0.0367343885872
ko00620	Pyruvate metabolism	2/1080	46/7206	0.0381494190077
ko00270	Cysteine and methionine metabolism	2/1080	47/7206	0.0383765026715
ko05219	Bladder cancer	2/1080	48/7206	0.0393333281264
ko04114	Oocyte meiosis	30/1080	139/7206	0.0402269062849
ko04217	Necroptosis	17/1080	178/7206	0.042661174116
ko05215	Prostate cancer	9/1080	111/7206	0.0433815812163
ko04115	p53 signaling pathway	5/1080	74/7206	0.0482851722035