ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1210	423/7206	1.75913172075e-47
ko04724	Glutamatergic synapse	89/1210	152/7206	6.04276242495e-32
ko05033	Nicotine addiction	47/1210	56/7206	2.84210370283e-28
ko05032	Morphine addiction	67/1210	110/7206	1.12482160199e-25
ko04713	Circadian entrainment	76/1210	136/7206	1.37268591909e-25
ko04727	GABAergic synapse	66/1210	110/7206	8.96134156988e-25
ko04721	Synaptic vesicle cycle	54/1210	80/7206	4.4949337915e-24
ko04728	Dopaminergic synapse	84/1210	185/7206	2.89570700631e-20
ko04725	Cholinergic synapse	76/1210	160/7206	7.13810075201e-20
ko04723	Retrograde endocannabinoid signaling	77/1210	175/7206	1.11653891911e-17
ko04911	Insulin secretion	58/1210	117/7206	1.61257802927e-16
ko04742	Taste transduction	39/1210	61/7206	1.74386646322e-16
ko04024	cAMP signaling pathway	102/1210	279/7206	4.8473933962e-16
ko04744	Phototransduction	28/1210	36/7206	1.1699018613e-15
ko04740	Olfactory transduction	44/1210	80/7206	5.81510913665e-15
ko04921	Oxytocin signaling pathway	81/1210	209/7206	1.19918758958e-14
ko04020	Calcium signaling pathway	95/1210	265/7206	2.85525430324e-14
ko04726	Serotonergic synapse	60/1210	137/7206	6.35968014256e-14
ko04970	Salivary secretion	45/1210	95/7206	3.27288147823e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1210	205/7206	3.44172149319e-11
ko04720	Long-term potentiation	44/1210	99/7206	8.21281410619e-11
ko03040	Spliceosome	1/1210	145/7206	1.18409652565e-10
ko05031	Amphetamine addiction	41/1210	91/7206	2.16707773337e-10
ko05168	Herpes simplex infection	5/1210	182/7206	2.24806118617e-09
ko04925	Aldosterone synthesis and secretion	43/1210	105/7206	3.07646680832e-09
ko05203	Viral carcinogenesis	14/1210	277/7206	3.1896131002e-09
ko04971	Gastric acid secretion	41/1210	98/7206	3.36744366e-09
ko04966	Collecting duct acid secretion	16/1210	26/7206	3.58558061218e-07
ko04120	Ubiquitin mediated proteolysis	4/1210	138/7206	4.03352055677e-07
ko04360	Axon guidance	70/1210	233/7206	4.05582217553e-07
ko03013	RNA transport	7/1210	166/7206	8.51610713892e-07
ko05164	Influenza A	7/1210	167/7206	8.80863384934e-07
ko04540	Gap junction	44/1210	128/7206	1.01092831241e-06
ko04022	cGMP-PKG signaling pathway	65/1210	216/7206	1.05743311453e-06
ko04060	Cytokine-cytokine receptor interaction	10/1210	191/7206	1.74401545523e-06
ko04745	Phototransduction - fly	19/1210	38/7206	2.32031097908e-06
ko04964	Proximal tubule bicarbonate reclamation	16/1210	29/7206	2.7610181843e-06
ko05030	Cocaine addiction	29/1210	73/7206	3.79679822238e-06
ko05162	Measles	4/1210	120/7206	6.14077594242e-06
ko04924	Renin secretion	32/1210	86/7206	6.23315415732e-06
ko04976	Bile secretion	30/1210	80/7206	6.93467713927e-06
ko04972	Pancreatic secretion	38/1210	111/7206	7.82588824793e-06
ko05169	Epstein-Barr virus infection	13/1210	206/7206	1.05366385307e-05
ko04730	Long-term depression	29/1210	78/7206	1.18688479464e-05
ko04621	NOD-like receptor signaling pathway	8/1210	157/7206	1.19399938945e-05
ko04141	Protein processing in endoplasmic reticulum	11/1210	184/7206	1.39733642037e-05
ko04260	Cardiac muscle contraction	34/1210	98/7206	1.47149023964e-05
ko04514	Cell adhesion molecules (CAMs)	41/1210	130/7206	2.65023364733e-05
ko05322	Systemic lupus erythematosus	8/1210	151/7206	3.52424381811e-05
ko05110	Vibrio cholerae infection	24/1210	63/7206	4.90805893511e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1210	74/7206	5.18968622453e-05
ko04610	Complement and coagulation cascades	2/1210	79/7206	0.000110200044541
ko03008	Ribosome biogenesis in eukaryotes	2/1210	79/7206	0.000110200044541
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1210	59/7206	0.000140026716565
ko04612	Antigen processing and presentation	2/1210	77/7206	0.000165748790784
ko04010	MAPK signaling pathway	80/1210	321/7206	0.000166105362312
ko05205	Proteoglycans in cancer	24/1210	271/7206	0.000178252987033
ko04110	Cell cycle	9/1210	145/7206	0.000188073126311
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1210	79/7206	0.00018914134189
ko05140	Leishmaniasis	2/1210	75/7206	0.000251053150381
ko04064	NF-kappa B signaling pathway	4/1210	96/7206	0.000272582784414
ko05414	Dilated cardiomyopathy	34/1210	112/7206	0.000308789836108
ko04214	Apoptosis - fly	2/1210	72/7206	0.000366534218093
ko05161	Hepatitis B	13/1210	173/7206	0.00042923275166
ko04750	Inflammatory mediator regulation of TRP channels	36/1210	122/7206	0.000519328594067
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1210	14/7206	0.000713890448121
ko04070	Phosphatidylinositol signaling system	33/1210	112/7206	0.000787035869648
ko04146	Peroxisome	4/1210	89/7206	0.000832249811353
ko00520	Amino sugar and nucleotide sugar metabolism	1/1210	55/7206	0.000836929590055
ko00480	Glutathione metabolism	1/1210	55/7206	0.000836929590055
ko05166	HTLV-I infection	29/1210	292/7206	0.000992231116668
ko04014	Ras signaling pathway	68/1210	279/7206	0.00102256462625
ko04626	Plant-pathogen interaction	9/1210	18/7206	0.00117669441035
ko04371	Apelin signaling pathway	46/1210	177/7206	0.00153983561493
ko00240	Pyrimidine metabolism	7/1210	110/7206	0.00182916170304
ko04915	Estrogen signaling pathway	36/1210	131/7206	0.00195799396978
ko04974	Protein digestion and absorption	28/1210	96/7206	0.00223779825574
ko04657	IL-17 signaling pathway	5/1210	87/7206	0.00350355197754
ko05321	Inflammatory bowel disease (IBD)	2/1210	56/7206	0.00380313065102
ko04668	TNF signaling pathway	9/1210	120/7206	0.00431599059762
ko00071	Fatty acid degradation	1/1210	45/7206	0.00432776090223
ko03420	Nucleotide excision repair	1/1210	46/7206	0.00448315024607
ko04912	GnRH signaling pathway	33/1210	122/7206	0.00454277960258
ko04978	Mineral absorption	14/1210	40/7206	0.00467306907276
ko01524	Platinum drug resistance	4/1210	76/7206	0.00483946561061
ko04923	Regulation of lipolysis in adipocytes	23/1210	77/7206	0.00505395738803
ko05418	Fluid shear stress and atherosclerosis	16/1210	173/7206	0.00532813748118
ko04640	Hematopoietic cell lineage	3/1210	64/7206	0.00639392176601
ko04072	Phospholipase D signaling pathway	48/1210	197/7206	0.00650809212942
ko00310	Lysine degradation	4/1210	73/7206	0.00675828481799
ko05131	Shigellosis	5/1210	82/7206	0.00685246298069
ko03022	Basal transcription factors	1/1210	44/7206	0.00693377546319
ko00590	Arachidonic acid metabolism	2/1210	52/7206	0.00818295601164
ko04916	Melanogenesis	36/1210	142/7206	0.00872775179251
ko04658	Th1 and Th2 cell differentiation	7/1210	96/7206	0.00879953260494
ko00330	Arginine and proline metabolism	3/1210	61/7206	0.0090798485052
ko04330	Notch signaling pathway	3/1210	62/7206	0.00931094390047
ko04622	RIG-I-like receptor signaling pathway	3/1210	62/7206	0.00931094390047
ko05215	Prostate cancer	9/1210	111/7206	0.010351736298
ko04350	TGF-beta signaling pathway	8/1210	103/7206	0.0111696298148
ko05145	Toxoplasmosis	11/1210	126/7206	0.0114717978172
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1210	182/7206	0.0116034812493
ko04630	Jak-STAT signaling pathway	12/1210	132/7206	0.0135758703469
ko00562	Inositol phosphate metabolism	24/1210	89/7206	0.0145087898656
ko00630	Glyoxylate and dicarboxylate metabolism	1/1210	38/7206	0.0147859061873
ko03410	Base excision repair	1/1210	38/7206	0.0147859061873
ko04620	Toll-like receptor signaling pathway	8/1210	100/7206	0.0149323409079
ko05212	Pancreatic cancer	6/1210	83/7206	0.0172447535891
ko03018	RNA degradation	6/1210	84/7206	0.0176145816591
ko04115	p53 signaling pathway	5/1210	74/7206	0.0180917204294
ko04270	Vascular smooth muscle contraction	37/1210	154/7206	0.0214339259043
ko00500	Starch and sucrose metabolism	1/1210	35/7206	0.0218897769294
ko05144	Malaria	2/1210	45/7206	0.0255195720915
ko04210	Apoptosis	19/1210	180/7206	0.0256766697418
ko00561	Glycerolipid metabolism	4/1210	63/7206	0.026131832946
ko00600	Sphingolipid metabolism	4/1210	63/7206	0.026131832946
ko00280	Valine, leucine and isoleucine degradation	3/1210	54/7206	0.0264495672799
ko00910	Nitrogen metabolism	7/1210	19/7206	0.0289700136495
ko05133	Pertussis	7/1210	87/7206	0.0292260880688
ko04922	Glucagon signaling pathway	31/1210	128/7206	0.0308879791661
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1210	100/7206	0.0312228885956
ko05217	Basal cell carcinoma	5/1210	68/7206	0.0337629417601
ko00640	Propanoate metabolism	1/1210	34/7206	0.0343951844257
ko00860	Porphyrin and chlorophyll metabolism	1/1210	34/7206	0.0343951844257
ko00380	Tryptophan metabolism	3/1210	50/7206	0.0367686429414
ko04142	Lysosome	16/1210	151/7206	0.0368332132299
ko05200	Pathways in cancer	66/1210	492/7206	0.0390809984742
ko05220	Chronic myeloid leukemia	7/1210	85/7206	0.0393812601639
ko05132	Salmonella infection	9/1210	98/7206	0.0411245945139
ko04930	Type II diabetes mellitus	15/1210	54/7206	0.042115676513
ko04217	Necroptosis	20/1210	178/7206	0.0425544618826
ko04140	Autophagy - animal	18/1210	164/7206	0.0443989311809
ko05222	Small cell lung cancer	8/1210	89/7206	0.0458905818362
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1210	92/7206	0.0477558792276
ko04659	Th17 cell differentiation	10/1210	106/7206	0.0482495317438
ko04512	ECM-receptor interaction	20/1210	79/7206	0.0485869413613
ko05340	Primary immunodeficiency	1/1210	30/7206	0.0486459530375
ko04015	Rap1 signaling pathway	59/1210	278/7206	0.0492652872334