ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1328	423/7206	6.88308935312e-51
ko04724	Glutamatergic synapse	92/1328	152/7206	2.8103188532e-31
ko05032	Morphine addiction	70/1328	110/7206	6.52970466116e-26
ko04713	Circadian entrainment	79/1328	136/7206	2.6202638407e-25
ko05033	Nicotine addiction	46/1328	56/7206	4.44558802608e-25
ko04727	GABAergic synapse	69/1328	110/7206	5.19834317896e-25
ko04020	Calcium signaling pathway	114/1328	265/7206	5.614835449e-21
ko04728	Dopaminergic synapse	87/1328	185/7206	1.97067057254e-19
ko04725	Cholinergic synapse	79/1328	160/7206	2.38557830681e-19
ko04721	Synaptic vesicle cycle	50/1328	80/7206	2.4086775855e-18
ko04024	cAMP signaling pathway	110/1328	279/7206	5.30757190948e-17
ko04723	Retrograde endocannabinoid signaling	79/1328	175/7206	1.87277491139e-16
ko04921	Oxytocin signaling pathway	89/1328	209/7206	2.07776357956e-16
ko04911	Insulin secretion	60/1328	117/7206	5.77701654294e-16
ko04726	Serotonergic synapse	64/1328	137/7206	2.00056320567e-14
ko04742	Taste transduction	38/1328	61/7206	3.53615330551e-14
ko04970	Salivary secretion	46/1328	95/7206	2.08992742135e-11
ko04261	Adrenergic signaling in cardiomyocytes	78/1328	205/7206	2.38291722056e-11
ko04744	Phototransduction	25/1328	36/7206	2.63478660146e-11
ko04022	cGMP-PKG signaling pathway	80/1328	216/7206	5.23716195492e-11
ko03010	Ribosome	1/1328	129/7206	2.1308682136e-10
ko05031	Amphetamine addiction	43/1328	91/7206	2.568392184e-10
ko04720	Long-term potentiation	44/1328	99/7206	1.83344920241e-09
ko03040	Spliceosome	4/1328	145/7206	1.30675574848e-08
ko05168	Herpes simplex infection	8/1328	182/7206	1.90444507052e-08
ko04925	Aldosterone synthesis and secretion	44/1328	105/7206	2.76052896501e-08
ko05322	Systemic lupus erythematosus	5/1328	151/7206	2.79795230982e-08
ko05203	Viral carcinogenesis	19/1328	277/7206	3.26945356016e-08
ko04971	Gastric acid secretion	41/1328	98/7206	5.62559338883e-08
ko04740	Olfactory transduction	35/1328	80/7206	2.11865974275e-07
ko03013	RNA transport	9/1328	166/7206	1.29819194973e-06
ko04110	Cell cycle	7/1328	145/7206	2.10745998501e-06
ko04730	Long-term depression	32/1328	78/7206	2.7345990575e-06
ko04060	Cytokine-cytokine receptor interaction	13/1328	191/7206	4.4879863838e-06
ko04540	Gap junction	45/1328	128/7206	5.18039048248e-06
ko05030	Cocaine addiction	30/1328	73/7206	5.4641580516e-06
ko04360	Axon guidance	71/1328	233/7206	6.34650067892e-06
ko04371	Apelin signaling pathway	57/1328	177/7206	7.79326075776e-06
ko04966	Collecting duct acid secretion	15/1328	26/7206	8.8940675756e-06
ko04924	Renin secretion	33/1328	86/7206	1.4953625554e-05
ko04621	NOD-like receptor signaling pathway	10/1328	157/7206	1.60380918246e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1328	74/7206	2.66226698135e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1328	79/7206	2.79661857546e-05
ko04010	MAPK signaling pathway	89/1328	321/7206	3.29768005087e-05
ko05414	Dilated cardiomyopathy	39/1328	112/7206	3.52370673842e-05
ko04014	Ras signaling pathway	79/1328	279/7206	3.75066302785e-05
ko05164	Influenza A	12/1328	167/7206	4.43941495682e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	30/1328	79/7206	4.93523068648e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1328	29/7206	5.11323438544e-05
ko04270	Vascular smooth muscle contraction	49/1328	154/7206	5.28775188049e-05
ko04260	Cardiac muscle contraction	35/1328	98/7206	5.66708936706e-05
ko04972	Pancreatic secretion	38/1328	111/7206	6.02827818679e-05
ko04120	Ubiquitin mediated proteolysis	9/1328	138/7206	8.48364682334e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1328	122/7206	0.000130340404005
ko04976	Bile secretion	29/1328	80/7206	0.000130910045055
ko04514	Cell adhesion molecules (CAMs)	42/1328	130/7206	0.000132623286263
ko04745	Phototransduction - fly	17/1328	38/7206	0.000167420616438
ko04070	Phosphatidylinositol signaling system	37/1328	112/7206	0.000185699088691
ko04610	Complement and coagulation cascades	3/1328	79/7206	0.000195069546098
ko04141	Protein processing in endoplasmic reticulum	16/1328	184/7206	0.00032284077413
ko05140	Leishmaniasis	3/1328	75/7206	0.000432961479535
ko04072	Phospholipase D signaling pathway	56/1328	197/7206	0.000516380602519
ko04923	Regulation of lipolysis in adipocytes	27/1328	77/7206	0.00051841694737
ko04930	Type II diabetes mellitus	21/1328	54/7206	0.000544635077423
ko05169	Epstein-Barr virus infection	20/1328	206/7206	0.000683214477511
ko04330	Notch signaling pathway	2/1328	62/7206	0.000745374240883
ko05110	Vibrio cholerae infection	23/1328	63/7206	0.000809370970627
ko05161	Hepatitis B	16/1328	173/7206	0.000981088764042
ko03420	Nucleotide excision repair	1/1328	46/7206	0.00174566991228
ko05205	Proteoglycans in cancer	31/1328	271/7206	0.00179157716545
ko00520	Amino sugar and nucleotide sugar metabolism	2/1328	55/7206	0.00241959481897
ko05410	Hypertrophic cardiomyopathy (HCM)	31/1328	100/7206	0.0024867080193
ko03022	Basal transcription factors	1/1328	44/7206	0.00268022758386
ko05162	Measles	10/1328	120/7206	0.00276886481483
ko04622	RIG-I-like receptor signaling pathway	3/1328	62/7206	0.00278837330168
ko04915	Estrogen signaling pathway	38/1328	131/7206	0.00288793921992
ko04217	Necroptosis	18/1328	178/7206	0.00312557304831
ko04214	Apoptosis - fly	4/1328	72/7206	0.00317138154994
ko04064	NF-kappa B signaling pathway	7/1328	96/7206	0.00320471406216
ko04657	IL-17 signaling pathway	6/1328	87/7206	0.00321709915939
ko05133	Pertussis	6/1328	87/7206	0.00321709915939
ko05166	HTLV-I infection	35/1328	292/7206	0.00329788664909
ko04922	Glucagon signaling pathway	37/1328	128/7206	0.00373191423541
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1328	59/7206	0.00385044151142
ko00240	Pyrimidine metabolism	9/1328	110/7206	0.00401470842916
ko04710	Circadian rhythm	16/1328	43/7206	0.0044857324088
ko05131	Shigellosis	6/1328	82/7206	0.006200969263
ko04658	Th1 and Th2 cell differentiation	8/1328	96/7206	0.0077190166987
ko05219	Bladder cancer	2/1328	48/7206	0.00772551363054
ko04146	Peroxisome	7/1328	89/7206	0.00830443371983
ko05321	Inflammatory bowel disease (IBD)	3/1328	56/7206	0.00850453979087
ko00010	Glycolysis / Gluconeogenesis	23/1328	74/7206	0.00943103516254
ko04626	Plant-pathogen interaction	8/1328	18/7206	0.00987197405658
ko04612	Antigen processing and presentation	6/1328	77/7206	0.0117889813648
ko00562	Inositol phosphate metabolism	26/1328	89/7206	0.012568883982
ko05230	Central carbon metabolism in cancer	24/1328	81/7206	0.013501683092
ko04960	Aldosterone-regulated sodium reabsorption	14/1328	41/7206	0.0143608639083
ko05145	Toxoplasmosis	13/1328	126/7206	0.0148795062354
ko04213	Longevity regulating pathway - multiple species	25/1328	86/7206	0.0163894803848
ko04630	Jak-STAT signaling pathway	14/1328	132/7206	0.0171292963419
ko04142	Lysosome	17/1328	151/7206	0.0194883621651
ko04350	TGF-beta signaling pathway	10/1328	103/7206	0.0205821263849
ko04916	Melanogenesis	37/1328	142/7206	0.021520261257
ko00710	Carbon fixation in photosynthetic organisms	10/1328	27/7206	0.0216486806585
ko04115	p53 signaling pathway	6/1328	74/7206	0.0224617905366
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1328	40/7206	0.0236901948966
ko00230	Purine metabolism	48/1328	194/7206	0.0242850231946
ko04973	Carbohydrate digestion and absorption	14/1328	42/7206	0.0253280839946
ko04620	Toll-like receptor signaling pathway	10/1328	100/7206	0.0268876313001
ko04113	Meiosis - yeast	6/1328	70/7206	0.0298570923201
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1328	14/7206	0.0302546851249
ko04210	Apoptosis	22/1328	180/7206	0.0316738781799
ko04015	Rap1 signaling pathway	65/1328	278/7206	0.033100217543
ko04912	GnRH signaling pathway	32/1328	122/7206	0.0331479084573
ko00280	Valine, leucine and isoleucine degradation	4/1328	54/7206	0.0339588905334
ko00480	Glutathione metabolism	4/1328	55/7206	0.0343920595596
ko03410	Base excision repair	2/1328	38/7206	0.0345013129229
ko05215	Prostate cancer	12/1328	111/7206	0.0357880974357
ko01524	Platinum drug resistance	7/1328	76/7206	0.0367381023527
ko05217	Basal cell carcinoma	6/1328	68/7206	0.040350008331
ko05212	Pancreatic cancer	8/1328	83/7206	0.0446906503237