ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	156/1023	423/7206	1.55672267951e-33
ko04724	Glutamatergic synapse	77/1023	152/7206	3.87413977615e-27
ko05033	Nicotine addiction	42/1023	56/7206	9.19442831903e-25
ko04721	Synaptic vesicle cycle	45/1023	80/7206	1.1531870456e-18
ko04727	GABAergic synapse	54/1023	110/7206	1.55507796428e-18
ko04713	Circadian entrainment	59/1023	136/7206	6.68743588342e-17
ko05032	Morphine addiction	51/1023	110/7206	3.04751313559e-16
ko04728	Dopaminergic synapse	70/1023	185/7206	5.3058227397e-16
ko04725	Cholinergic synapse	61/1023	160/7206	2.88515828332e-14
ko04723	Retrograde endocannabinoid signaling	63/1023	175/7206	2.38037317233e-13
ko04360	Axon guidance	75/1023	233/7206	1.05763139269e-12
ko04024	cAMP signaling pathway	83/1023	279/7206	8.35377030495e-12
ko04742	Taste transduction	31/1023	61/7206	1.09774971849e-11
ko04911	Insulin secretion	45/1023	117/7206	5.27823851936e-11
ko03040	Spliceosome	1/1023	145/7206	9.19078274743e-09
ko05030	Cocaine addiction	29/1023	73/7206	6.31722203117e-08
ko04726	Serotonergic synapse	44/1023	137/7206	7.15811338486e-08
ko05203	Viral carcinogenesis	12/1023	277/7206	8.90331225935e-08
ko05031	Amphetamine addiction	33/1023	91/7206	1.06791878798e-07
ko05164	Influenza A	4/1023	167/7206	2.60946019162e-07
ko04261	Adrenergic signaling in cardiomyocytes	56/1023	205/7206	6.74068178554e-07
ko04720	Long-term potentiation	33/1023	99/7206	1.24433225741e-06
ko04514	Cell adhesion molecules (CAMs)	40/1023	130/7206	1.29375043613e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1023	74/7206	1.33474162924e-06
ko05168	Herpes simplex infection	6/1023	182/7206	1.40735380823e-06
ko04744	Phototransduction	17/1023	36/7206	2.02435919112e-06
ko04020	Calcium signaling pathway	66/1023	265/7206	2.36925129555e-06
ko03013	RNA transport	5/1023	166/7206	2.43776839379e-06
ko04120	Ubiquitin mediated proteolysis	4/1023	138/7206	1.18583956539e-05
ko05322	Systemic lupus erythematosus	5/1023	151/7206	1.52045684145e-05
ko04921	Oxytocin signaling pathway	53/1023	209/7206	1.82904463445e-05
ko04621	NOD-like receptor signaling pathway	6/1023	157/7206	2.50238400511e-05
ko04010	MAPK signaling pathway	73/1023	321/7206	2.5895712738e-05
ko04740	Olfactory transduction	26/1023	80/7206	2.78351412018e-05
ko04060	Cytokine-cytokine receptor interaction	9/1023	191/7206	3.27244438261e-05
ko04141	Protein processing in endoplasmic reticulum	9/1023	184/7206	6.2533960068e-05
ko05169	Epstein-Barr virus infection	11/1023	206/7206	6.49196692606e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/1023	182/7206	8.78077408252e-05
ko04970	Salivary secretion	28/1023	95/7206	9.13690651385e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1023	79/7206	0.000129257908263
ko05162	Measles	4/1023	120/7206	0.000165361772561
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1023	14/7206	0.000217476771391
ko03018	RNA degradation	2/1023	84/7206	0.000438338486098
ko04214	Apoptosis - fly	1/1023	72/7206	0.000469181546065
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1023	79/7206	0.000503811087568
ko01200	Carbon metabolism	6/1023	128/7206	0.000782782541113
ko04540	Gap junction	32/1023	128/7206	0.00119389320049
ko05140	Leishmaniasis	2/1023	75/7206	0.0013892558723
ko00330	Arginine and proline metabolism	1/1023	61/7206	0.00147179573376
ko04925	Aldosterone synthesis and secretion	27/1023	105/7206	0.00166294401512
ko04966	Collecting duct acid secretion	10/1023	26/7206	0.00194278058794
ko04022	cGMP-PKG signaling pathway	47/1023	216/7206	0.00206135611499
ko00240	Pyrimidine metabolism	5/1023	110/7206	0.00211597168894
ko04064	NF-kappa B signaling pathway	4/1023	96/7206	0.00278407661954
ko04730	Long-term depression	21/1023	78/7206	0.00283694693997
ko04971	Gastric acid secretion	25/1023	98/7206	0.00306511236433
ko00480	Glutathione metabolism	1/1023	55/7206	0.00329447438942
ko05321	Inflammatory bowel disease (IBD)	1/1023	56/7206	0.00329724105206
ko04915	Estrogen signaling pathway	31/1023	131/7206	0.00335174225745
ko04110	Cell cycle	9/1023	145/7206	0.00364152447381
ko04972	Pancreatic secretion	27/1023	111/7206	0.00373996598511
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1023	59/7206	0.00388065920936
ko05205	Proteoglycans in cancer	23/1023	271/7206	0.00445881443542
ko04924	Renin secretion	22/1023	86/7206	0.00461922121539
ko04950	Maturity onset diabetes of the young	10/1023	29/7206	0.00490636840994
ko04146	Peroxisome	4/1023	89/7206	0.00538900250908
ko04640	Hematopoietic cell lineage	2/1023	64/7206	0.00628418780243
ko04072	Phospholipase D signaling pathway	42/1023	197/7206	0.00675391796751
ko00010	Glycolysis / Gluconeogenesis	3/1023	74/7206	0.00711088544428
ko00590	Arachidonic acid metabolism	1/1023	52/7206	0.00781977987011
ko04976	Bile secretion	20/1023	80/7206	0.00917297964694
ko00561	Glycerolipid metabolism	2/1023	63/7206	0.00961749326919
ko05131	Shigellosis	4/1023	82/7206	0.0104875437155
ko05204	Chemical carcinogenesis	1/1023	48/7206	0.0110537691858
ko04217	Necroptosis	14/1023	178/7206	0.0120867391118
ko04260	Cardiac muscle contraction	23/1023	98/7206	0.0124971698305
ko04138	Autophagy - yeast	4/1023	81/7206	0.0149920455843
ko03022	Basal transcription factors	1/1023	44/7206	0.0161019517598
ko05144	Malaria	1/1023	45/7206	0.0163540548078
ko00071	Fatty acid degradation	1/1023	45/7206	0.0163540548078
ko03420	Nucleotide excision repair	1/1023	46/7206	0.0170068282433
ko04140	Autophagy - animal	13/1023	164/7206	0.0172414891521
ko04974	Protein digestion and absorption	22/1023	96/7206	0.0181822858332
ko05414	Dilated cardiomyopathy	25/1023	112/7206	0.0193676415384
ko04657	IL-17 signaling pathway	5/1023	87/7206	0.0197254754714
ko05133	Pertussis	5/1023	87/7206	0.0197254754714
ko05145	Toxoplasmosis	9/1023	126/7206	0.0198964068646
ko05418	Fluid shear stress and atherosclerosis	14/1023	173/7206	0.0199357475482
ko04962	Vasopressin-regulated water reabsorption	15/1023	58/7206	0.0208975672431
ko04391	Hippo signaling pathway - fly	21/1023	90/7206	0.0211024169651
ko04512	ECM-receptor interaction	19/1023	79/7206	0.0214646503908
ko04014	Ras signaling pathway	53/1023	279/7206	0.0227247971648
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1023	26/7206	0.0235617117743
ko00983	Drug metabolism - other enzymes	1/1023	42/7206	0.024162550836
ko00051	Fructose and mannose metabolism	1/1023	42/7206	0.024162550836
ko04142	Lysosome	12/1023	151/7206	0.0246760593306
ko04622	RIG-I-like receptor signaling pathway	3/1023	62/7206	0.0283114983793
ko00600	Sphingolipid metabolism	3/1023	63/7206	0.0283576073772
ko00280	Valine, leucine and isoleucine degradation	2/1023	54/7206	0.0284841872792
ko05161	Hepatitis B	15/1023	173/7206	0.0356036639095
ko05012	Parkinson's disease	13/1023	155/7206	0.0357784535428
ko04137	Mitophagy - animal	5/1023	82/7206	0.0368815848459
ko04916	Melanogenesis	29/1023	142/7206	0.0383550104575
ko00380	Tryptophan metabolism	2/1023	50/7206	0.0395102137191
ko00564	Glycerophospholipid metabolism	7/1023	99/7206	0.0414413851782
ko05146	Amoebiasis	7/1023	99/7206	0.0414413851782
ko04620	Toll-like receptor signaling pathway	7/1023	100/7206	0.041881686606
ko04930	Type II diabetes mellitus	13/1023	54/7206	0.048079738653
ko04612	Antigen processing and presentation	5/1023	77/7206	0.0491233504371