ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	144/971	423/7206	3.70961144011e-29
ko04724	Glutamatergic synapse	72/971	152/7206	1.41783382552e-24
ko05033	Nicotine addiction	40/971	56/7206	3.56341413722e-23
ko04721	Synaptic vesicle cycle	44/971	80/7206	1.17045443741e-18
ko04728	Dopaminergic synapse	70/971	185/7206	3.121578365e-17
ko04727	GABAergic synapse	51/971	110/7206	3.22365853427e-17
ko05032	Morphine addiction	49/971	110/7206	1.02463832888e-15
ko04713	Circadian entrainment	54/971	136/7206	1.39116468729e-14
ko04725	Cholinergic synapse	59/971	160/7206	4.09068619681e-14
ko04360	Axon guidance	75/971	233/7206	5.946168869e-14
ko04723	Retrograde endocannabinoid signaling	58/971	175/7206	1.93021004962e-11
ko04024	cAMP signaling pathway	78/971	279/7206	7.45467850064e-11
ko04911	Insulin secretion	43/971	117/7206	1.42461948341e-10
ko04742	Taste transduction	27/971	61/7206	3.62051952597e-09
ko03040	Spliceosome	1/971	145/7206	2.29970218416e-08
ko05203	Viral carcinogenesis	11/971	277/7206	1.25761077418e-07
ko05030	Cocaine addiction	27/971	73/7206	3.38362291793e-07
ko04726	Serotonergic synapse	41/971	137/7206	3.69042044477e-07
ko05031	Amphetamine addiction	31/971	91/7206	3.94829138361e-07
ko04261	Adrenergic signaling in cardiomyocytes	54/971	205/7206	6.53343939511e-07
ko03013	RNA transport	4/971	166/7206	1.37759923092e-06
ko04514	Cell adhesion molecules (CAMs)	38/971	130/7206	1.78620319716e-06
ko05168	Herpes simplex infection	6/971	182/7206	4.50907827949e-06
ko04744	Phototransduction	16/971	36/7206	5.42499080973e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/971	74/7206	6.20342423194e-06
ko04120	Ubiquitin mediated proteolysis	3/971	138/7206	6.48202396177e-06
ko04621	NOD-like receptor signaling pathway	5/971	157/7206	1.58790995399e-05
ko04060	Cytokine-cytokine receptor interaction	8/971	191/7206	2.32346598907e-05
ko05164	Influenza A	6/971	167/7206	2.70468831681e-05
ko04720	Long-term potentiation	29/971	99/7206	3.57927279815e-05
ko04740	Olfactory transduction	24/971	80/7206	9.47263058027e-05
ko04010	MAPK signaling pathway	68/971	321/7206	0.000106043441679
ko04020	Calcium signaling pathway	58/971	265/7206	0.000148801650606
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/971	14/7206	0.000149414358281
ko05322	Systemic lupus erythematosus	6/971	151/7206	0.000152558567322
ko04141	Protein processing in endoplasmic reticulum	9/971	184/7206	0.000174341130225
ko04921	Oxytocin signaling pathway	48/971	209/7206	0.000181196914371
ko03008	Ribosome biogenesis in eukaryotes	1/971	79/7206	0.000204984095354
ko04970	Salivary secretion	26/971	95/7206	0.000359620636931
ko01200	Carbon metabolism	5/971	128/7206	0.000561498374989
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/971	79/7206	0.000673395638132
ko04214	Apoptosis - fly	1/971	72/7206	0.000708497822089
ko04540	Gap junction	31/971	128/7206	0.00092680128713
ko03018	RNA degradation	2/971	84/7206	0.00101868789291
ko05169	Epstein-Barr virus infection	13/971	206/7206	0.00124689788068
ko04064	NF-kappa B signaling pathway	3/971	96/7206	0.00127821039622
ko04260	Cardiac muscle contraction	25/971	98/7206	0.00142588048742
ko04640	Hematopoietic cell lineage	1/971	64/7206	0.00153669228473
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/971	59/7206	0.00167379430346
ko00330	Arginine and proline metabolism	1/971	61/7206	0.00229120407061
ko00561	Glycerolipid metabolism	1/971	63/7206	0.00236015385019
ko04146	Peroxisome	3/971	89/7206	0.00256525653628
ko00240	Pyrimidine metabolism	5/971	110/7206	0.00295261600667
ko05140	Leishmaniasis	2/971	75/7206	0.00318242510461
ko04950	Maturity onset diabetes of the young	10/971	29/7206	0.00333717400035
ko04730	Long-term depression	20/971	78/7206	0.0038484125168
ko05162	Measles	6/971	120/7206	0.0041933722799
ko04022	cGMP-PKG signaling pathway	44/971	216/7206	0.00437236930521
ko05321	Inflammatory bowel disease (IBD)	1/971	56/7206	0.00509232180898
ko04966	Collecting duct acid secretion	9/971	26/7206	0.00514762931069
ko04924	Renin secretion	21/971	86/7206	0.00604601851643
ko04971	Gastric acid secretion	23/971	98/7206	0.00664737803449
ko05224	Breast cancer	36/971	174/7206	0.00684893250193
ko04972	Pancreatic secretion	25/971	111/7206	0.00754013388088
ko04925	Aldosterone synthesis and secretion	24/971	105/7206	0.00869772544326
ko04974	Protein digestion and absorption	22/971	96/7206	0.0099954180548
ko04340	Hedgehog signaling pathway	15/971	58/7206	0.0105546912717
ko04142	Lysosome	10/971	151/7206	0.0108990056379
ko04964	Proximal tubule bicarbonate reclamation	9/971	29/7206	0.0113599444521
ko04014	Ras signaling pathway	52/971	279/7206	0.0122275503607
ko04976	Bile secretion	19/971	80/7206	0.0122349251216
ko04916	Melanogenesis	30/971	142/7206	0.012279029182
ko04915	Estrogen signaling pathway	28/971	131/7206	0.0132767545505
ko04217	Necroptosis	13/971	178/7206	0.0139005297519
ko05205	Proteoglycans in cancer	23/971	271/7206	0.013975889429
ko03420	Nucleotide excision repair	1/971	46/7206	0.0165246136253
ko00270	Cysteine and methionine metabolism	1/971	47/7206	0.0166396329532
ko05145	Toxoplasmosis	8/971	126/7206	0.0169735964657
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/971	26/7206	0.0175900353631
ko04391	Hippo signaling pathway - fly	20/971	90/7206	0.0193857318604
ko04140	Autophagy - animal	12/971	164/7206	0.019913114403
ko04512	ECM-receptor interaction	18/971	79/7206	0.0199746263899
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/971	182/7206	0.0203266209556
ko03320	PPAR signaling pathway	3/971	69/7206	0.0206194065984
ko04138	Autophagy - yeast	4/971	81/7206	0.0208390957302
ko05131	Shigellosis	4/971	82/7206	0.0211969899517
ko03022	Basal transcription factors	1/971	44/7206	0.0246096151791
ko00071	Fatty acid degradation	1/971	45/7206	0.0253202126872
ko00564	Glycerophospholipid metabolism	6/971	99/7206	0.0258493652302
ko00480	Glutathione metabolism	2/971	55/7206	0.0279036221259
ko00430	Taurine and hypotaurine metabolism	5/971	14/7206	0.0308399480183
ko04072	Phospholipase D signaling pathway	37/971	197/7206	0.0337084553044
ko05414	Dilated cardiomyopathy	23/971	112/7206	0.0353695956041
ko00980	Metabolism of xenobiotics by cytochrome P450	1/971	40/7206	0.0359829763472
ko04110	Cell cycle	11/971	145/7206	0.036058741453
ko00140	Steroid hormone biosynthesis	1/971	41/7206	0.0363258756106
ko00983	Drug metabolism - other enzymes	1/971	42/7206	0.0373797669293
ko00051	Fructose and mannose metabolism	1/971	42/7206	0.0373797669293
ko05133	Pertussis	5/971	87/7206	0.0380447508508
ko00010	Glycolysis / Gluconeogenesis	4/971	74/7206	0.0392169631535
ko04115	p53 signaling pathway	4/971	74/7206	0.0392169631535
ko05134	Legionellosis	4/971	74/7206	0.0392169631535
ko00590	Arachidonic acid metabolism	2/971	52/7206	0.0399020193142
ko01524	Platinum drug resistance	4/971	76/7206	0.0403564969957
ko00600	Sphingolipid metabolism	3/971	63/7206	0.0404031233146
ko04622	RIG-I-like receptor signaling pathway	3/971	62/7206	0.0404123424932
ko04011	MAPK signaling pathway - yeast	2/971	53/7206	0.0405925602144
ko02024	Quorum sensing	5/971	15/7206	0.0412678697265
ko05418	Fluid shear stress and atherosclerosis	14/971	173/7206	0.0414663595482
ko04930	Type II diabetes mellitus	13/971	54/7206	0.0418772508623
ko04550	Signaling pathways regulating pluripotency of stem cells	31/971	165/7206	0.0494409162665