ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 52/350 145/7206 1.90435223983e-32 ko03013 RNA transport 43/350 166/7206 1.53797709815e-20 ko04110 Cell cycle 33/350 145/7206 3.41687448843e-14 ko03460 Fanconi anemia pathway 19/350 51/7206 7.92316483165e-13 ko04111 Cell cycle - yeast 24/350 90/7206 3.18565556785e-12 ko03008 Ribosome biogenesis in eukaryotes 22/350 79/7206 1.01841059649e-11 ko03440 Homologous recombination 16/350 41/7206 2.32302072337e-11 ko04113 Meiosis - yeast 16/350 70/7206 1.53224701096e-07 ko03018 RNA degradation 16/350 84/7206 2.1148610326e-06 ko03022 Basal transcription factors 11/350 44/7206 5.47867252778e-06 ko00240 Pyrimidine metabolism 17/350 110/7206 1.94027138641e-05 ko05322 Systemic lupus erythematosus 20/350 151/7206 3.76044408601e-05 ko04151 PI3K-Akt signaling pathway 4/350 390/7206 4.64723207162e-05 ko04144 Endocytosis 3/350 342/7206 5.10164887323e-05 ko03030 DNA replication 9/350 38/7206 6.31903936162e-05 ko03015 mRNA surveillance pathway 14/350 93/7206 0.000140745076778 ko04024 cAMP signaling pathway 2/350 279/7206 0.000165688240246 ko03020 RNA polymerase 7/350 29/7206 0.000370496046868 ko03410 Base excision repair 8/350 38/7206 0.000387888641342 ko04022 cGMP-PKG signaling pathway 1/350 216/7206 0.000528289538485 ko04510 Focal adhesion 2/350 240/7206 0.00106654374943 ko04072 Phospholipase D signaling pathway 1/350 197/7206 0.00108922518561 ko05205 Proteoglycans in cancer 3/350 271/7206 0.00128735961222 ko04810 Regulation of actin cytoskeleton 3/350 264/7206 0.00184326624325 ko04921 Oxytocin signaling pathway 2/350 209/7206 0.00304568798242 ko04015 Rap1 signaling pathway 4/350 278/7206 0.00393646630433 ko04914 Progesterone-mediated oocyte maturation 12/350 104/7206 0.0043685677177 ko04261 Adrenergic signaling in cardiomyocytes 2/350 205/7206 0.00439957427829 ko04152 AMPK signaling pathway 1/350 161/7206 0.00484198457684 ko03420 Nucleotide excision repair 7/350 46/7206 0.00625075532593 ko04724 Glutamatergic synapse 1/350 152/7206 0.00703483294142 ko04530 Tight junction 3/350 228/7206 0.00704706983596 ko05012 Parkinson's disease 1/350 155/7206 0.00710428922618 ko04621 NOD-like receptor signaling pathway 1/350 157/7206 0.00724558972893 ko04114 Oocyte meiosis 14/350 139/7206 0.0083019995899 ko00310 Lysine degradation 9/350 73/7206 0.00843290716596 ko04728 Dopaminergic synapse 2/350 185/7206 0.00877086903542 ko05152 Tuberculosis 2/350 187/7206 0.00881848154321 ko04390 Hippo signaling pathway 2/350 188/7206 0.00887031842488 ko04014 Ras signaling pathway 5/350 279/7206 0.0101842133623 ko04371 Apelin signaling pathway 2/350 177/7206 0.0124226121821 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/350 182/7206 0.0128332756197 ko04713 Circadian entrainment 1/350 136/7206 0.0147757612635 ko04931 Insulin resistance 1/350 137/7206 0.0148049314818 ko05200 Pathways in cancer 13/350 492/7206 0.0162934568721 ko04723 Retrograde endocannabinoid signaling 2/350 175/7206 0.0184188729352 ko04062 Chemokine signaling pathway 3/350 201/7206 0.0188024808285 ko05010 Alzheimer's disease 3/350 202/7206 0.018871128464 ko03430 Mismatch repair 4/350 22/7206 0.01997841458 ko00190 Oxidative phosphorylation 1/350 127/7206 0.0213528553229 ko05203 Viral carcinogenesis 22/350 277/7206 0.0214959844768 ko05166 HTLV-I infection 23/350 292/7206 0.0246546475293 ko04725 Cholinergic synapse 2/350 160/7206 0.0246746810074 ko04611 Platelet activation 2/350 163/7206 0.0249799013569 ko04115 p53 signaling pathway 8/350 74/7206 0.0263437804693 ko05034 Alcoholism 19/350 238/7206 0.0304680129053 ko04668 TNF signaling pathway 1/350 120/7206 0.0308157294555 ko04750 Inflammatory mediator regulation of TRP channels 1/350 122/7206 0.0310922475712 ko04666 Fc gamma R-mediated phagocytosis 1/350 122/7206 0.0310922475712 ko04066 HIF-1 signaling pathway 1/350 123/7206 0.0313364671912 ko04139 Mitophagy - yeast 5/350 37/7206 0.0318953760838 ko04218 Cellular senescence 15/350 177/7206 0.0319421861557 ko03450 Non-homologous end-joining 3/350 15/7206 0.0334536666665 ko04142 Lysosome 2/350 151/7206 0.0345923207052 ko04972 Pancreatic secretion 1/350 111/7206 0.0442911453715 ko04727 GABAergic synapse 1/350 110/7206 0.0443071287225 ko05032 Morphine addiction 1/350 110/7206 0.0443071287225 ko04010 MAPK signaling pathway 8/350 321/7206 0.0451449666468 ko05418 Fluid shear stress and atherosclerosis 3/350 173/7206 0.0486955187719