ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 38/597 80/7206 9.1041448017e-21 ko04728 Dopaminergic synapse 52/597 185/7206 7.14294112597e-16 ko04724 Glutamatergic synapse 46/597 152/7206 1.6785744921e-15 ko05033 Nicotine addiction 26/597 56/7206 2.75025821463e-14 ko04713 Circadian entrainment 39/597 136/7206 1.73287485412e-12 ko05032 Morphine addiction 32/597 110/7206 1.19664767615e-10 ko04727 GABAergic synapse 31/597 110/7206 5.65858196092e-10 ko04723 Retrograde endocannabinoid signaling 40/597 175/7206 1.81576433918e-09 ko04261 Adrenergic signaling in cardiomyocytes 43/597 205/7206 7.28899231228e-09 ko04080 Neuroactive ligand-receptor interaction 70/597 423/7206 9.46532554646e-09 ko04911 Insulin secretion 30/597 117/7206 1.24214569817e-08 ko04725 Cholinergic synapse 36/597 160/7206 1.87277211602e-08 ko04024 cAMP signaling pathway 51/597 279/7206 4.55759134515e-08 ko05031 Amphetamine addiction 25/597 91/7206 4.73043091868e-08 ko04720 Long-term potentiation 25/597 99/7206 2.84336526396e-07 ko04966 Collecting duct acid secretion 12/597 26/7206 3.06668588641e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 21/597 74/7206 3.11150987407e-07 ko05030 Cocaine addiction 19/597 73/7206 4.73626399867e-06 ko04514 Cell adhesion molecules (CAMs) 27/597 130/7206 5.88869262646e-06 ko04970 Salivary secretion 22/597 95/7206 6.90317838732e-06 ko04360 Axon guidance 39/597 233/7206 1.70560020797e-05 ko04745 Phototransduction - fly 12/597 38/7206 3.39678961191e-05 ko04022 cGMP-PKG signaling pathway 36/597 216/7206 4.32685608933e-05 ko04726 Serotonergic synapse 26/597 137/7206 5.26085764449e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/597 14/7206 5.29688355114e-05 ko04060 Cytokine-cytokine receptor interaction 3/597 191/7206 9.25939290053e-05 ko04744 Phototransduction 11/597 36/7206 0.000101290718376 ko04921 Oxytocin signaling pathway 34/597 209/7206 0.000108343699334 ko05110 Vibrio cholerae infection 15/597 63/7206 0.000142952966407 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/597 92/7206 0.00015240386875 ko04145 Phagosome 28/597 162/7206 0.000222882447911 ko04626 Plant-pathogen interaction 7/597 18/7206 0.000365842989069 ko04924 Renin secretion 17/597 86/7206 0.000574530564144 ko05162 Measles 1/597 120/7206 0.000635952371679 ko03040 Spliceosome 2/597 145/7206 0.000638721467116 ko05203 Viral carcinogenesis 9/597 277/7206 0.000797368934421 ko03013 RNA transport 3/597 166/7206 0.00083946373739 ko04971 Gastric acid secretion 18/597 98/7206 0.00119427573544 ko04020 Calcium signaling pathway 37/597 265/7206 0.0013725710747 ko04114 Oocyte meiosis 23/597 139/7206 0.00148436100312 ko04010 MAPK signaling pathway 42/597 321/7206 0.00253636035215 ko05146 Amoebiasis 1/597 99/7206 0.00294099407524 ko05168 Herpes simplex infection 5/597 182/7206 0.00377655172097 ko04730 Long-term depression 14/597 78/7206 0.00551100815255 ko05034 Alcoholism 32/597 238/7206 0.00563520756615 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/597 15/7206 0.00571513055511 ko05010 Alzheimer's disease 28/597 202/7206 0.00615781677121 ko04146 Peroxisome 1/597 89/7206 0.00631006992414 ko05322 Systemic lupus erythematosus 4/597 151/7206 0.00679295936335 ko05161 Hepatitis B 5/597 173/7206 0.00721582913166 ko04510 Focal adhesion 9/597 240/7206 0.00821057514074 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/597 59/7206 0.00822770503156 ko05164 Influenza A 5/597 167/7206 0.00968850316846 ko04211 Longevity regulating pathway 3/597 123/7206 0.0124901548447 ko04014 Ras signaling pathway 35/597 279/7206 0.0141352805834 ko05323 Rheumatoid arthritis 14/597 89/7206 0.0180355528625 ko04925 Aldosterone synthesis and secretion 16/597 105/7206 0.0181634476843 ko05140 Leishmaniasis 1/597 75/7206 0.0195592659064 ko04740 Olfactory transduction 13/597 80/7206 0.0215266519403 ko00190 Oxidative phosphorylation 18/597 127/7206 0.0218355238077 ko04922 Glucagon signaling pathway 18/597 128/7206 0.0227868494764 ko04972 Pancreatic secretion 16/597 111/7206 0.0239155665495 ko04630 Jak-STAT signaling pathway 4/597 132/7206 0.0243258270149 ko04214 Apoptosis - fly 1/597 72/7206 0.0288728515904 ko00512 Mucin type O-glycan biosynthesis 6/597 29/7206 0.0289159092317 ko05166 HTLV-I infection 14/597 292/7206 0.0293142570164 ko00310 Lysine degradation 1/597 73/7206 0.0294017719736 ko04611 Platelet activation 6/597 163/7206 0.0298865043252 ko05152 Tuberculosis 24/597 187/7206 0.0303074726141 ko04621 NOD-like receptor signaling pathway 6/597 157/7206 0.039375370238 ko04120 Ubiquitin mediated proteolysis 5/597 138/7206 0.0421009734689 ko04668 TNF signaling pathway 4/597 120/7206 0.0444484824235 ko05220 Chronic myeloid leukemia 2/597 85/7206 0.0455687237741 ko01522 Endocrine resistance 4/597 124/7206 0.0459726737295 ko04350 TGF-beta signaling pathway 3/597 103/7206 0.0459900857161