ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1064	423/7206	3.85132089129e-48
ko05033	Nicotine addiction	43/1064	56/7206	2.44247507453e-25
ko04724	Glutamatergic synapse	76/1064	152/7206	3.42363828906e-25
ko04728	Dopaminergic synapse	78/1064	185/7206	5.3967328006e-20
ko04713	Circadian entrainment	64/1064	136/7206	1.35375314807e-19
ko05032	Morphine addiction	56/1064	110/7206	2.58367755066e-19
ko04721	Synaptic vesicle cycle	45/1064	80/7206	5.59782360827e-18
ko04727	GABAergic synapse	52/1064	110/7206	3.03295069825e-16
ko04020	Calcium signaling pathway	90/1064	265/7206	1.40071743643e-15
ko04024	cAMP signaling pathway	92/1064	279/7206	4.93930418562e-15
ko04725	Cholinergic synapse	63/1064	160/7206	1.19598518421e-14
ko04723	Retrograde endocannabinoid signaling	66/1064	175/7206	3.23615508397e-14
ko04726	Serotonergic synapse	55/1064	137/7206	2.34901183774e-13
ko04911	Insulin secretion	48/1064	117/7206	3.16546640077e-12
ko04921	Oxytocin signaling pathway	70/1064	209/7206	5.76133954824e-12
ko04742	Taste transduction	31/1064	61/7206	3.11942319997e-11
ko04970	Salivary secretion	40/1064	95/7206	8.02884354424e-11
ko05031	Amphetamine addiction	38/1064	91/7206	3.21067907591e-10
ko04261	Adrenergic signaling in cardiomyocytes	64/1064	205/7206	1.34556381002e-09
ko04740	Olfactory transduction	32/1064	80/7206	2.84047999866e-08
ko04060	Cytokine-cytokine receptor interaction	5/1064	191/7206	3.53732227934e-08
ko04925	Aldosterone synthesis and secretion	38/1064	105/7206	3.6777291432e-08
ko03040	Spliceosome	2/1064	145/7206	4.08921952215e-08
ko04971	Gastric acid secretion	36/1064	98/7206	5.40075315178e-08
ko04720	Long-term potentiation	36/1064	99/7206	7.3047475734e-08
ko05203	Viral carcinogenesis	13/1064	277/7206	8.92902845822e-08
ko04514	Cell adhesion molecules (CAMs)	42/1064	130/7206	3.05592783323e-07
ko05030	Cocaine addiction	28/1064	73/7206	5.86292059515e-07
ko04120	Ubiquitin mediated proteolysis	3/1064	138/7206	1.20933968297e-06
ko04022	cGMP-PKG signaling pathway	58/1064	216/7206	3.33099728468e-06
ko04924	Renin secretion	30/1064	86/7206	3.43455903729e-06
ko04744	Phototransduction	17/1064	36/7206	3.5302361077e-06
ko04966	Collecting duct acid secretion	14/1064	26/7206	3.64672856538e-06
ko03013	RNA transport	6/1064	166/7206	3.91910575745e-06
ko04972	Pancreatic secretion	35/1064	111/7206	8.80906884519e-06
ko05168	Herpes simplex infection	8/1064	182/7206	1.04971852811e-05
ko04730	Long-term depression	27/1064	78/7206	1.27430853049e-05
ko04010	MAPK signaling pathway	76/1064	321/7206	1.68377727907e-05
ko04976	Bile secretion	27/1064	80/7206	1.81755590655e-05
ko05322	Systemic lupus erythematosus	6/1064	151/7206	2.37520935584e-05
ko04540	Gap junction	37/1064	128/7206	3.92886232034e-05
ko04745	Phototransduction - fly	16/1064	38/7206	4.08407758543e-05
ko05110	Vibrio cholerae infection	22/1064	63/7206	5.22918329172e-05
ko04621	NOD-like receptor signaling pathway	7/1064	157/7206	5.36365354486e-05
ko05164	Influenza A	8/1064	167/7206	5.72072450563e-05
ko05166	HTLV-I infection	21/1064	292/7206	6.95624819909e-05
ko04978	Mineral absorption	16/1064	40/7206	8.62528640997e-05
ko04964	Proximal tubule bicarbonate reclamation	13/1064	29/7206	9.9439381206e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	24/1064	74/7206	0.000101224682605
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1064	79/7206	0.000151973104935
ko04110	Cell cycle	7/1064	145/7206	0.000207489091276
ko04214	Apoptosis - fly	1/1064	72/7206	0.000299130092599
ko05162	Measles	5/1064	120/7206	0.000366784296841
ko04750	Inflammatory mediator regulation of TRP channels	33/1064	122/7206	0.000410183672072
ko04626	Plant-pathogen interaction	9/1064	18/7206	0.00044465479463
ko03008	Ribosome biogenesis in eukaryotes	2/1064	79/7206	0.000627839083244
ko05169	Epstein-Barr virus infection	14/1064	206/7206	0.000630722484193
ko04141	Protein processing in endoplasmic reticulum	12/1064	184/7206	0.00069330642841
ko05161	Hepatitis B	11/1064	173/7206	0.000728078584373
ko04260	Cardiac muscle contraction	27/1064	98/7206	0.0008544392046
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1064	182/7206	0.000936487474184
ko04612	Antigen processing and presentation	2/1064	77/7206	0.000949931846042
ko04630	Jak-STAT signaling pathway	7/1064	132/7206	0.0011087541265
ko05414	Dilated cardiomyopathy	29/1064	112/7206	0.00180138355577
ko04360	Axon guidance	52/1064	233/7206	0.00182350790712
ko04014	Ras signaling pathway	60/1064	279/7206	0.00188831527626
ko05205	Proteoglycans in cancer	23/1064	271/7206	0.00215423047196
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1064	59/7206	0.0024120503949
ko04070	Phosphatidylinositol signaling system	28/1064	112/7206	0.00433058407204
ko04064	NF-kappa B signaling pathway	5/1064	96/7206	0.00540278364678
ko04915	Estrogen signaling pathway	31/1064	131/7206	0.00596234861815
ko04330	Notch signaling pathway	2/1064	62/7206	0.00616226093512
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1064	100/7206	0.00645737075753
ko00310	Lysine degradation	3/1064	73/7206	0.00706422374283
ko05219	Bladder cancer	1/1064	48/7206	0.00711958753945
ko05215	Prostate cancer	7/1064	111/7206	0.00970759438497
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1064	165/7206	0.0102406165541
ko05144	Malaria	1/1064	45/7206	0.0106018831662
ko00071	Fatty acid degradation	1/1064	45/7206	0.0106018831662
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1064	14/7206	0.0106029174413
ko03420	Nucleotide excision repair	1/1064	46/7206	0.0107491760852
ko00480	Glutathione metabolism	2/1064	55/7206	0.0129020955655
ko05321	Inflammatory bowel disease (IBD)	2/1064	56/7206	0.0129031750008
ko04658	Th1 and Th2 cell differentiation	6/1064	96/7206	0.0136021770996
ko04657	IL-17 signaling pathway	5/1064	87/7206	0.0141708718771
ko01524	Platinum drug resistance	4/1064	76/7206	0.0142971461425
ko04142	Lysosome	12/1064	151/7206	0.0145820408023
ko04270	Vascular smooth muscle contraction	34/1064	154/7206	0.0152067383736
ko03022	Basal transcription factors	1/1064	44/7206	0.0164619272106
ko00280	Valine, leucine and isoleucine degradation	2/1064	54/7206	0.0189437756168
ko04974	Protein digestion and absorption	23/1064	96/7206	0.0191825988497
ko03018	RNA degradation	5/1064	84/7206	0.0194017627975
ko05220	Chronic myeloid leukemia	5/1064	85/7206	0.0197196434008
ko04115	p53 signaling pathway	4/1064	74/7206	0.0199770499596
ko04923	Regulation of lipolysis in adipocytes	19/1064	77/7206	0.0221031032084
ko04371	Apelin signaling pathway	37/1064	177/7206	0.0239919998239
ko04217	Necroptosis	16/1064	178/7206	0.0247166913097
ko04210	Apoptosis	16/1064	180/7206	0.0248457031273
ko04140	Autophagy - animal	14/1064	164/7206	0.0251468690675
ko04622	RIG-I-like receptor signaling pathway	3/1064	62/7206	0.0286880826268
ko05206	MicroRNAs in cancer	16/1064	177/7206	0.0312213202709
ko04146	Peroxisome	6/1064	89/7206	0.033820012137
ko00630	Glyoxylate and dicarboxylate metabolism	1/1064	38/7206	0.0355599167091
ko03410	Base excision repair	1/1064	38/7206	0.0355599167091
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1064	92/7206	0.0371058591384
ko05217	Basal cell carcinoma	4/1064	68/7206	0.0379795247063
ko05016	Huntington's disease	21/1064	215/7206	0.0397340055811
ko05200	Pathways in cancer	57/1064	492/7206	0.0410709601025
ko04916	Melanogenesis	30/1064	142/7206	0.0411563471854
ko01200	Carbon metabolism	11/1064	128/7206	0.0445565053464
ko04015	Rap1 signaling pathway	53/1064	278/7206	0.046860204424
ko04973	Carbohydrate digestion and absorption	11/1064	42/7206	0.0473065228455
ko05140	Leishmaniasis	5/1064	75/7206	0.0485176963262
ko04350	TGF-beta signaling pathway	8/1064	103/7206	0.0487941006271