ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/235 134/7206 9.44802617964e-14 ko04060 Cytokine-cytokine receptor interaction 27/235 191/7206 7.70878685789e-11 ko05321 Inflammatory bowel disease (IBD) 15/235 56/7206 1.59015102932e-10 ko05140 Leishmaniasis 17/235 75/7206 1.6513053662e-10 ko04064 NF-kappa B signaling pathway 19/235 96/7206 1.65371802766e-10 ko05145 Toxoplasmosis 20/235 126/7206 3.25390805633e-09 ko05164 Influenza A 23/235 167/7206 3.59429614539e-09 ko04621 NOD-like receptor signaling pathway 22/235 157/7206 5.77225184912e-09 ko05152 Tuberculosis 24/235 187/7206 6.80376241681e-09 ko05162 Measles 19/235 120/7206 8.54759344603e-09 ko04650 Natural killer cell mediated cytotoxicity 16/235 97/7206 7.4087556493e-08 ko04620 Toll-like receptor signaling pathway 16/235 100/7206 1.15212264913e-07 ko04672 Intestinal immune network for IgA production 10/235 37/7206 1.80534510408e-07 ko05168 Herpes simplex infection 21/235 182/7206 3.9696510284e-07 ko05161 Hepatitis B 20/235 173/7206 7.3691109351e-07 ko05144 Malaria 10/235 45/7206 1.31405366898e-06 ko04660 T cell receptor signaling pathway 16/235 124/7206 2.31309597118e-06 ko05320 Autoimmune thyroid disease 8/235 29/7206 2.69392436854e-06 ko05340 Primary immunodeficiency 8/235 30/7206 3.5711069881e-06 ko05142 Chagas disease (American trypanosomiasis) 16/235 130/7206 4.34342403251e-06 ko04217 Necroptosis 19/235 178/7206 4.7055743455e-06 ko05323 Rheumatoid arthritis 13/235 89/7206 5.26519735067e-06 ko04659 Th17 cell differentiation 14/235 106/7206 7.64988994292e-06 ko05330 Allograft rejection 7/235 24/7206 7.72687527285e-06 ko04610 Complement and coagulation cascades 12/235 79/7206 8.06992803187e-06 ko04658 Th1 and Th2 cell differentiation 13/235 96/7206 1.23412014939e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/235 191/7206 1.31879595268e-05 ko04630 Jak-STAT signaling pathway 15/235 132/7206 2.30997806293e-05 ko04668 TNF signaling pathway 14/235 120/7206 3.22726096804e-05 ko04145 Phagosome 16/235 162/7206 7.04771196325e-05 ko04210 Apoptosis 17/235 180/7206 7.36931870662e-05 ko05160 Hepatitis C 15/235 153/7206 0.000129260472476 ko04612 Antigen processing and presentation 10/235 77/7206 0.00018084012941 ko04664 Fc epsilon RI signaling pathway 10/235 77/7206 0.00018084012941 ko05332 Graft-versus-host disease 5/235 18/7206 0.000213831398614 ko04072 Phospholipase D signaling pathway 17/235 197/7206 0.000223350527636 ko05146 Amoebiasis 11/235 99/7206 0.000351911522748 ko04670 Leukocyte transendothelial migration 14/235 151/7206 0.000387773504844 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/235 135/7206 0.000433356217797 ko04662 B cell receptor signaling pathway 10/235 88/7206 0.000543870528691 ko04622 RIG-I-like receptor signaling pathway 8/235 62/7206 0.00083844721554 ko05166 HTLV-I infection 20/235 292/7206 0.00187592132179 ko05310 Asthma 4/235 17/7206 0.00187684066544 ko05133 Pertussis 9/235 87/7206 0.00200437587854 ko04666 Fc gamma R-mediated phagocytosis 11/235 122/7206 0.00203053514504 ko04611 Platelet activation 13/235 163/7206 0.00249225353066 ko05134 Legionellosis 8/235 74/7206 0.00267331931115 ko04062 Chemokine signaling pathway 15/235 201/7206 0.00345344618427 ko04940 Type I diabetes mellitus 5/235 32/7206 0.00346318145169 ko05169 Epstein-Barr virus infection 15/235 206/7206 0.00388641810481 ko05132 Salmonella infection 9/235 98/7206 0.00451456210172 ko05034 Alcoholism 1/235 238/7206 0.00495565209525 ko05212 Pancreatic cancer 8/235 83/7206 0.0054472031158 ko05150 Staphylococcus aureus infection 5/235 36/7206 0.00583343134962 ko05416 Viral myocarditis 6/235 55/7206 0.00860355091421 ko04514 Cell adhesion molecules (CAMs) 10/235 130/7206 0.0097765126025 ko01524 Platinum drug resistance 7/235 76/7206 0.0116029334217 ko05418 Fluid shear stress and atherosclerosis 12/235 173/7206 0.0137932439218 ko04066 HIF-1 signaling pathway 9/235 123/7206 0.0187850711032 ko05220 Chronic myeloid leukemia 7/235 85/7206 0.020507009518 ko04917 Prolactin signaling pathway 7/235 87/7206 0.0229957517458 ko05222 Small cell lung cancer 7/235 89/7206 0.0256858743356 ko00120 Primary bile acid biosynthesis 3/235 20/7206 0.0259076641098 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/235 92/7206 0.0301129295587 ko04310 Wnt signaling pathway 1/235 181/7206 0.0316865736132 ko04142 Lysosome 10/235 151/7206 0.0318538637939 ko04623 Cytosolic DNA-sensing pathway 4/235 41/7206 0.0435100906065 ko00051 Fructose and mannose metabolism 4/235 42/7206 0.0469067689638 ko05016 Huntington's disease 2/235 215/7206 0.0492675943811