ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 25/160 134/7206 7.94645641823e-17 ko04060 Cytokine-cytokine receptor interaction 25/160 191/7206 4.11696302898e-13 ko05161 Hepatitis B 23/160 173/7206 2.81148439497e-12 ko04621 NOD-like receptor signaling pathway 22/160 157/7206 2.96831644725e-12 ko05164 Influenza A 21/160 167/7206 7.95399433767e-11 ko05168 Herpes simplex infection 21/160 182/7206 4.08159284754e-10 ko05162 Measles 17/160 120/7206 8.75264910297e-10 ko04668 TNF signaling pathway 17/160 120/7206 8.75264910297e-10 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/160 191/7206 1.00600923754e-09 ko04630 Jak-STAT signaling pathway 17/160 132/7206 3.93879773821e-09 ko04620 Toll-like receptor signaling pathway 15/160 100/7206 4.04000947451e-09 ko05160 Hepatitis C 18/160 153/7206 5.84208917182e-09 ko05140 Leishmaniasis 13/160 75/7206 7.5324464875e-09 ko05145 Toxoplasmosis 16/160 126/7206 1.42838116493e-08 ko04064 NF-kappa B signaling pathway 14/160 96/7206 1.98541536348e-08 ko05321 Inflammatory bowel disease (IBD) 11/160 56/7206 2.88261992123e-08 ko04660 T cell receptor signaling pathway 15/160 124/7206 8.02994846021e-08 ko04622 RIG-I-like receptor signaling pathway 11/160 62/7206 8.77166498038e-08 ko05323 Rheumatoid arthritis 12/160 89/7206 5.14819440231e-07 ko04672 Intestinal immune network for IgA production 8/160 37/7206 1.10741862757e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/160 135/7206 1.49662746927e-06 ko04217 Necroptosis 16/160 178/7206 1.78976649745e-06 ko04210 Apoptosis 16/160 180/7206 2.07598780476e-06 ko05152 Tuberculosis 16/160 187/7206 3.43148475246e-06 ko04659 Th17 cell differentiation 12/160 106/7206 3.44554698706e-06 ko05144 Malaria 8/160 45/7206 5.31655949566e-06 ko05166 HTLV-I infection 20/160 292/7206 6.26768980967e-06 ko05330 Allograft rejection 6/160 24/7206 1.05437906028e-05 ko04917 Prolactin signaling pathway 10/160 87/7206 2.02238477078e-05 ko04657 IL-17 signaling pathway 10/160 87/7206 2.02238477078e-05 ko05340 Primary immunodeficiency 6/160 30/7206 4.16537178838e-05 ko04658 Th1 and Th2 cell differentiation 10/160 96/7206 4.80391388411e-05 ko04650 Natural killer cell mediated cytotoxicity 10/160 97/7206 5.25509807231e-05 ko05133 Pertussis 9/160 87/7206 0.000122165512799 ko05142 Chagas disease (American trypanosomiasis) 11/160 130/7206 0.000136657003024 ko05169 Epstein-Barr virus infection 14/160 206/7206 0.000181723484335 ko04623 Cytosolic DNA-sensing pathway 6/160 41/7206 0.000257782102752 ko04612 Antigen processing and presentation 8/160 77/7206 0.000284289312945 ko05320 Autoimmune thyroid disease 5/160 29/7206 0.000391058331857 ko04062 Chemokine signaling pathway 13/160 201/7206 0.000501177140867 ko05332 Graft-versus-host disease 4/160 18/7206 0.000561742769068 ko04662 B cell receptor signaling pathway 8/160 88/7206 0.000706660220491 ko04670 Leukocyte transendothelial migration 10/160 151/7206 0.00187769812628 ko05131 Shigellosis 7/160 82/7206 0.00219663401892 ko04145 Phagosome 10/160 162/7206 0.00314654723624 ko04931 Insulin resistance 9/160 137/7206 0.0033244359272 ko04920 Adipocytokine signaling pathway 7/160 89/7206 0.00349913666889 ko04940 Type I diabetes mellitus 4/160 32/7206 0.00518544806218 ko05310 Asthma 3/160 17/7206 0.00581076321633 ko05134 Legionellosis 6/160 74/7206 0.00582386307865 ko04080 Neuroactive ligand-receptor interaction 2/160 423/7206 0.00603079141449 ko05416 Viral myocarditis 5/160 55/7206 0.00721089013337 ko05212 Pancreatic cancer 6/160 83/7206 0.0100858269 ko05220 Chronic myeloid leukemia 6/160 85/7206 0.0112729034205 ko05418 Fluid shear stress and atherosclerosis 9/160 173/7206 0.0146489122522 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/160 92/7206 0.0162052900306 ko05200 Pathways in cancer 19/160 492/7206 0.0163408544802 ko04218 Cellular senescence 9/160 177/7206 0.0167840445651 ko04010 MAPK signaling pathway 14/160 321/7206 0.0171836690276 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/160 182/7206 0.0197638886128 ko05132 Salmonella infection 6/160 98/7206 0.0214814675155 ko05146 Amoebiasis 6/160 99/7206 0.022461548921 ko04664 Fc epsilon RI signaling pathway 5/160 77/7206 0.027820819902 ko04610 Complement and coagulation cascades 5/160 79/7206 0.0306462296544 ko04930 Type II diabetes mellitus 4/160 54/7206 0.0313624767026 ko04137 Mitophagy - animal 5/160 82/7206 0.035212359422 ko05210 Colorectal cancer 5/160 86/7206 0.0419242604147 ko00660 C5-Branched dibasic acid metabolism 1/160 2/7206 0.0439174463881 ko05150 Staphylococcus aureus infection 3/160 36/7206 0.0449503590263