ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 28/109 423/7206 1.36455804329e-11 ko05033 Nicotine addiction 12/109 56/7206 2.4852321294e-11 ko04724 Glutamatergic synapse 17/109 152/7206 8.15868470943e-11 ko04727 GABAergic synapse 14/109 110/7206 7.73322937636e-10 ko04713 Circadian entrainment 15/109 136/7206 1.41802645111e-09 ko04024 cAMP signaling pathway 19/109 279/7206 2.76601377263e-08 ko05032 Morphine addiction 11/109 110/7206 6.95827855918e-07 ko04723 Retrograde endocannabinoid signaling 13/109 175/7206 2.00976511299e-06 ko04725 Cholinergic synapse 12/109 160/7206 4.63184504224e-06 ko05031 Amphetamine addiction 9/109 91/7206 8.29223087033e-06 ko05030 Cocaine addiction 8/109 73/7206 1.25884573083e-05 ko04911 Insulin secretion 9/109 117/7206 6.30292844022e-05 ko04728 Dopaminergic synapse 11/109 185/7206 0.000101898454564 ko04744 Phototransduction 5/109 36/7206 0.000187398185178 ko04742 Taste transduction 6/109 61/7206 0.000294780599689 ko04720 Long-term potentiation 7/109 99/7206 0.000708752884505 ko04726 Serotonergic synapse 8/109 137/7206 0.00105273207092 ko04921 Oxytocin signaling pathway 9/109 209/7206 0.004244281828 ko04925 Aldosterone synthesis and secretion 6/109 105/7206 0.00499969152498 ko05014 Amyotrophic lateral sclerosis (ALS) 5/109 74/7206 0.00508422689493 ko04020 Calcium signaling pathway 10/109 265/7206 0.00660397691741 ko04966 Collecting duct acid secretion 3/109 26/7206 0.0067958145593 ko04721 Synaptic vesicle cycle 5/109 80/7206 0.00706568463788 ko04740 Olfactory transduction 5/109 80/7206 0.00706568463788 ko05034 Alcoholism 9/109 238/7206 0.00972628270753 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/109 1/7206 0.0151262836526 ko00430 Taurine and hypotaurine metabolism 2/109 14/7206 0.0183245644237 ko04745 Phototransduction - fly 3/109 38/7206 0.0193493543963 ko02024 Quorum sensing 2/109 15/7206 0.0209372875098 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/109 15/7206 0.0209372875098 ko01051 Biosynthesis of ansamycins 1/109 2/7206 0.0300258305068 ko04730 Long-term depression 4/109 78/7206 0.0300649824006 ko04540 Gap junction 5/109 128/7206 0.0442057158195