ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 37/402 134/7206 8.81204267632e-17 ko04621 NOD-like receptor signaling pathway 40/402 157/7206 1.02754176233e-16 ko04064 NF-kappa B signaling pathway 26/402 96/7206 6.41124945762e-12 ko04060 Cytokine-cytokine receptor interaction 36/402 191/7206 5.93961652042e-11 ko04668 TNF signaling pathway 26/402 120/7206 1.36934256478e-09 ko05164 Influenza A 31/402 167/7206 2.00799140346e-09 ko05168 Herpes simplex infection 32/402 182/7206 4.46687964947e-09 ko05162 Measles 25/402 120/7206 6.75321020698e-09 ko04217 Necroptosis 31/402 178/7206 9.96668562765e-09 ko04620 Toll-like receptor signaling pathway 22/402 100/7206 1.94359403773e-08 ko04622 RIG-I-like receptor signaling pathway 17/402 62/7206 2.54698978673e-08 ko05161 Hepatitis B 29/402 173/7206 7.2838146749e-08 ko04657 IL-17 signaling pathway 19/402 87/7206 2.07851257718e-07 ko04630 Jak-STAT signaling pathway 24/402 132/7206 2.12169263935e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/402 191/7206 6.45705970545e-07 ko04623 Cytosolic DNA-sensing pathway 12/402 41/7206 1.39081149147e-06 ko05140 Leishmaniasis 16/402 75/7206 2.67215847211e-06 ko05145 Toxoplasmosis 21/402 126/7206 5.28500081837e-06 ko00350 Tyrosine metabolism 10/402 33/7206 7.58615998114e-06 ko00643 Styrene degradation 4/402 4/7206 9.54966090907e-06 ko05160 Hepatitis C 23/402 153/7206 1.12938935453e-05 ko04210 Apoptosis 25/402 180/7206 1.9328300658e-05 ko05133 Pertussis 16/402 87/7206 1.99482808469e-05 ko05321 Inflammatory bowel disease (IBD) 12/402 56/7206 4.58182250959e-05 ko05152 Tuberculosis 25/402 187/7206 5.61823476426e-05 ko00120 Primary bile acid biosynthesis 7/402 20/7206 6.56171655845e-05 ko04659 Th17 cell differentiation 17/402 106/7206 6.92674382459e-05 ko04658 Th1 and Th2 cell differentiation 16/402 96/7206 7.01984123158e-05 ko05132 Salmonella infection 16/402 98/7206 9.06541030644e-05 ko05142 Chagas disease (American trypanosomiasis) 19/402 130/7206 9.68668284883e-05 ko00140 Steroid hormone biosynthesis 9/402 41/7206 0.000339515220166 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/402 4/7206 0.000660937057653 ko04723 Retrograde endocannabinoid signaling 1/402 175/7206 0.000713194619513 ko05134 Legionellosis 12/402 74/7206 0.000723687281873 ko04062 Chemokine signaling pathway 23/402 201/7206 0.000877026046048 ko04662 B cell receptor signaling pathway 13/402 88/7206 0.00109150123533 ko05034 Alcoholism 3/402 238/7206 0.0012993871512 ko04610 Complement and coagulation cascades 12/402 79/7206 0.00131242867554 ko04080 Neuroactive ligand-receptor interaction 10/402 423/7206 0.00146114863611 ko03013 RNA transport 1/402 166/7206 0.00159555472969 ko05131 Shigellosis 12/402 82/7206 0.00182560218874 ko00360 Phenylalanine metabolism 5/402 17/7206 0.00186493162942 ko04660 T cell receptor signaling pathway 16/402 124/7206 0.00213193450363 ko04650 Natural killer cell mediated cytotoxicity 13/402 97/7206 0.00268829186161 ko04917 Prolactin signaling pathway 12/402 87/7206 0.00303974024568 ko05144 Malaria 8/402 45/7206 0.00304941688918 ko05150 Staphylococcus aureus infection 7/402 36/7206 0.00325637713504 ko04724 Glutamatergic synapse 1/402 152/7206 0.00341380889656 ko05323 Rheumatoid arthritis 12/402 89/7206 0.00367965654415 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/402 135/7206 0.00371999986623 ko04672 Intestinal immune network for IgA production 7/402 37/7206 0.00382779924837 ko04310 Wnt signaling pathway 2/402 181/7206 0.0044636901409 ko04114 Oocyte meiosis 1/402 139/7206 0.00475152587516 ko04360 Axon guidance 4/402 233/7206 0.00532837327597 ko05340 Primary immunodeficiency 6/402 30/7206 0.00549485164742 ko04713 Circadian entrainment 1/402 136/7206 0.00704414439591 ko00590 Arachidonic acid metabolism 8/402 52/7206 0.00757742804179 ko04390 Hippo signaling pathway 3/402 188/7206 0.00961824481721 ko05012 Parkinson's disease 2/402 155/7206 0.0122679991074 ko04931 Insulin resistance 15/402 137/7206 0.0124108878496 ko04728 Dopaminergic synapse 3/402 185/7206 0.0136155898001 ko04611 Platelet activation 17/402 163/7206 0.0137524679199 ko00950 Isoquinoline alkaloid biosynthesis 3/402 10/7206 0.0154109334863 ko05322 Systemic lupus erythematosus 2/402 151/7206 0.01781795728 ko04932 Non-alcoholic fatty liver disease (NAFLD) 18/402 182/7206 0.0199917603183 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/402 11/7206 0.0203273541314 ko04916 Melanogenesis 2/402 142/7206 0.0246649432109 ko05146 Amoebiasis 11/402 99/7206 0.0247472231117 ko04110 Cell cycle 2/402 145/7206 0.0255378907342 ko00051 Fructose and mannose metabolism 6/402 42/7206 0.0277070347988 ko00983 Drug metabolism - other enzymes 6/402 42/7206 0.0277070347988 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/402 5/7206 0.0277418152303 ko05169 Epstein-Barr virus infection 19/402 206/7206 0.0294453453866 ko04914 Progesterone-mediated oocyte maturation 1/402 104/7206 0.0303468839971 ko05143 African trypanosomiasis 5/402 32/7206 0.0305532413306 ko04920 Adipocytokine signaling pathway 10/402 89/7206 0.0316381846359 ko04727 GABAergic synapse 1/402 110/7206 0.032209366615 ko05032 Morphine addiction 1/402 110/7206 0.032209366615 ko05016 Huntington's disease 5/402 215/7206 0.0333316231457 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/402 92/7206 0.0365018093908 ko01524 Platinum drug resistance 9/402 76/7206 0.0372340537449 ko04975 Fat digestion and absorption 5/402 35/7206 0.0430254109158 ko04215 Apoptosis - multiple species 6/402 47/7206 0.0450169321955 ko04666 Fc gamma R-mediated phagocytosis 12/402 122/7206 0.0460737371314 ko00190 Oxidative phosphorylation 2/402 127/7206 0.0483379321111 ko04540 Gap junction 2/402 128/7206 0.048731362318 ko05204 Chemical carcinogenesis 6/402 48/7206 0.0491352988269